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    Aebp2 AE binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297705, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Aebp2provided by RGD
    Official Full Name
    AE binding protein 2provided by RGD
    Primary source
    RGD:1307233
    See related
    EnsemblRapid:ENSRNOG00000008929 AllianceGenome:RGD:1307233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of ESC/E(Z) complex. Orthologous to human AEBP2 (AE binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 93.3), Adrenal (RPKM 87.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aebp2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (175258286..175297149)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (173527881..173566033)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (174799378..174863260)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A5 Neighboring gene uncharacterized LOC134486859 Neighboring gene uncharacterized LOC120102424 Neighboring gene uncharacterized LOC134486860 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression. He GP, et al. J Biol Chem, 1999 May 21. PMID 10329662
    2. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, et al. Trends Biochem Sci, 2013 Dec. PMID 24148750, Free PMC Article
    3. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Peng JC, et al. Cell, 2009 Dec 24. PMID 20064375, Free PMC Article
    4. EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Ragazzini R, et al. Nat Commun, 2019 Aug 26. PMID 31451685, Free PMC Article
    5. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Pasini D, et al. Nature, 2010 Mar 11. PMID 20075857

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein AEBP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401545.1 → NP_001388474.1  zinc finger protein AEBP2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AAA0
      Related
      ENSRNOP00000105958.1, ENSRNOT00000143260.1
      Conserved Domains (2) summary
      COG5048
      Location:209 → 356
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:258 → 278
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      175258286..175297149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107463.2 → XP_038963391.1  zinc finger protein AEBP2 isoform X3

      UniProtKB/TrEMBL
      A6IMN6, D3ZED3
      Related
      ENSRNOP00000036497.5, ENSRNOT00000035507.6
      Conserved Domains (2) summary
      COG5048
      Location:3 → 110
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:37 → 57
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_039107462.2 → XP_038963390.1  zinc finger protein AEBP2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AAA0
      Related
      ENSRNOP00000107875.1, ENSRNOT00000124909.1
      Conserved Domains (2) summary
      COG5048
      Location:209 → 356
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:258 → 278
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_039107461.2 → XP_038963389.1  zinc finger protein AEBP2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A054
      Related
      ENSRNOP00000083013.2, ENSRNOT00000110876.2
      Conserved Domains (3) summary
      COG5048
      Location:209 → 356
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:258 → 278
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:307 → 333
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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