U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Melk maternal embryonic leucine zipper kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362510, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Melkprovided by RGD
    Official Full Name
    maternal embryonic leucine zipper kinaseprovided by RGD
    Primary source
    RGD:1308974
    See related
    EnsemblRapid:ENSRNOG00000013598 AllianceGenome:RGD:1308974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including neural precursor cell proliferation; positive regulation of apoptotic process; and protein autophosphorylation. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Predicted to be located in cell cortex and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 71.4), Testes (RPKM 24.5) and 8 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Melk in Genome Data Viewer
    Location:
    5q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (63336151..63396254)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (58540393..58600562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (59783835..59844356)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene ring finger protein 38 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene heterogeneous nuclear ribonucleoprotein K-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression of Melk, a new protein kinase, during early mouse development. Heyer BS, et al. Dev Dyn, 1999 Aug. PMID 10417823
    2. Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. Chartrain I, et al. Biol Cell, 2006 Apr. PMID 16159311
    3. Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells. Gil M, et al. Gene, 1997 Aug 22. PMID 9305775
    4. Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Lin ML, et al. Breast Cancer Res, 2007. PMID 17280616, Free PMC Article
    5. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. Mirey G, et al. Cell Cycle, 2005 Jun. PMID 15908796

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    maternal embryonic leucine zipper kinase
    NP_001382535.1
    XP_063143978.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395606.1 → NP_001382535.1  maternal embryonic leucine zipper kinase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4A6T6
      Related
      ENSRNOP00000059313.4, ENSRNOT00000066277.4
      Conserved Domains (3) summary
      cd12198
      Location:547 → 641
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      cd14341
      Location:281 → 332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7 → 263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      63336151..63396254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287908.1 → XP_063143978.1  maternal embryonic leucine zipper kinase isoform X1

      UniProtKB/TrEMBL
      D4A6T6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108662.1: Suppressed sequence

      Description
      NM_001108662.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools