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    Mpzl1 myelin protein zero-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360871, updated on 17-Aug-2024

    Summary

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    Symbol
    Mpzl1provided by RGD
    Full Name
    myelin protein zero-like 1provided by RGD
    Primary source
    RGD:1359140
    See related
    EnsemblRapid:ENSRNOG00000003248 AllianceGenome:RGD:1359140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of cell migration. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human MPZL1 (myelin protein zero like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 222.6), Uterus (RPKM 130.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpzl1 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80385454..80422315, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77852467..77889305, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83805244..83842074, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481587 Neighboring gene adenylate cyclase 10 Neighboring gene uncharacterized LOC134481588 Neighboring gene transfer RNA proline (anticodon AGG) 14 Neighboring gene transfer RNA proline (anticodon CGG) 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation. Roubelakis MG, et al. J Cell Biochem, 2007 Nov 1. PMID 17440960
    2. Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling. Zhao R, et al. J Biol Chem, 2002 Mar 8. PMID 11751924
    3. Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs. Zhao R, et al. J Biol Chem, 2000 Feb 25. PMID 10681522
    4. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
    5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93692

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myelin protein zero-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007728.2 → NP_001007729.1  myelin protein zero-like protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001007729.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6AYT8
      UniProtKB/TrEMBL
      A0A8I6A952, A6IDH5
      Related
      ENSRNOP00000004376.4, ENSRNOT00000004376.7
      Conserved Domains (2) summary
      cd00096
      Location:38 → 42
      Ig; Ig strand A [structural motif]
      cl11960
      Location:38 → 154
      Ig; Immunoglobulin domain

    2. NM_001429783.1 → NP_001416712.1  myelin protein zero-like protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6A9E7, A6IDH6, A6IDH7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80385454..80422315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250180.5 → XP_006250242.1  myelin protein zero-like protein 1 isoform X1

      Related
      ENSRNOP00000089948.2, ENSRNOT00000093821.2
      Conserved Domains (2) summary
      cd05715
      Location:39 → 154
      Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
      smart00410
      Location:43 → 154
      IG_like; Immunoglobulin like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYT8.1 GenPept UniProtKB/Swiss-Prot:Q6AYT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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