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    Ang angiogenin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305843, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Angprovided by RGD
    Official Full Name
    angiogeninprovided by RGD
    Primary source
    RGD:1594539
    See related
    AllianceGenome:RGD:1594539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ang1
    Summary
    Predicted to enable several functions, including heparin binding activity; protein homodimerization activity; and tRNA-specific ribonuclease activity. Involved in liver development. Predicted to be located in several cellular components, including cytoplasmic stress granule; growth cone; and neuronal cell body. Predicted to be part of angiogenin-PRI complex. Predicted to be active in cytoplasm and nucleus. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 3843.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ang in Genome Data Viewer
    Location:
    15p14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26786233..26796883)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24312711..24323361)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28022926..28028636)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tyrosine (anticodon GUA) 4 Neighboring gene transfer RNA proline (anticodon UGG) 6 Neighboring gene ribonuclease A family member 4 Neighboring gene ribonuclease, RNase A family, 1-like 1 Neighboring gene epididymal protein 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Angiogenin expression and prognosis in primary breast carcinoma. Montero S, et al. Clin Cancer Res, 1998 Sep. PMID 9748135
    2. Comparison of cytokeratin 20 RNA and angiogenin in voided urine samples as diagnostic tools for bladder carcinoma. Eissa S, et al. Clin Biochem, 2004 Sep. PMID 15329320
    3. Serum concentrations of insulin-like growth factor-1, soluble tumor necrosis factor receptor-1 and angiogenin in endometriosis patients. Steff AM, et al. Am J Reprod Immunol, 2004 Feb. PMID 14748845
    4. Increased plasma levels of angiogenin and the risk of bladder carcinoma: from initiation ot recurrence. Zhao H, et al. Cancer, 2005 Jul 1. PMID 15912517
    5. Elevated angiogenin levels in synovial fluid from patients with inflammatory arthritis and secretion of angiogenin by cultured synovial fibroblasts. Lioté F, et al. Clin Exp Immunol, 2003 Apr. PMID 12653852, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Matrine inhibits synovial angiogenesis in collagen-induced arthritis rats by regulating HIF-VEGF-Ang and inhibiting the PI3K/Akt signaling pathway.
      Title: Matrine inhibits synovial angiogenesis in collagen-induced arthritis rats by regulating HIF-VEGF-Ang and inhibiting the PI3K/Akt signaling pathway.
    2. ANG induced intraocular pressure (IOP) lowering in rat models of both normal and elevated IOP.
      Title: Ribonuclease 5 coordinates signals for the regulation of intraocular pressure and inhibits neural apoptosis as a novel multi-functional anti-glaucomatous strategy.
    3. The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin.
      Title: The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex.
    4. oxygen-glucose deprivation could induce the expressions of VEGF, Ang-1, and Ang-2, with the expression of Shh signaling components increased.
      Title: Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.
    5. Ang1 induces neurite outgrowth in PC12 cells in a Tie2-independent, beta1-integrin-FAK-PI3K-Akt-dependent manner. NGF and Ang1 mediate neurite outgrowth via two independent signaling mechanisms.
      Title: Angiopoietin-1 induces neurite outgrowth of PC12 cells in a Tie2-independent, beta1-integrin-dependent manner.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antifungal humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation in response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to yeast ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of angiogenin-PRI complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    angiogenin
    Names
    angiogenin ribonuclease 1
    angiogenin, ribonuclease A family, member 1
    angiogenin, ribonuclease, RNase A family, 5
    ribonuclease 4
    NP_001006993.2
    NP_001398935.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006992.2 → NP_001006993.2  angiogenin precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      Q5GAM6, W0UV65

    2. NM_001412006.1 → NP_001398935.1  angiogenin precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      Q5GAM6, W0UV65

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      26786233..26796883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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