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    Stard13 StAR-related lipid transfer domain containing 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498130, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Stard13provided by RGD
    Official Full Name
    StAR-related lipid transfer domain containing 13provided by RGD
    Primary source
    RGD:1564816
    See related
    EnsemblRapid:ENSRNOG00000001090 AllianceGenome:RGD:1564816
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564816
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Predicted to act upstream of or within several processes, including endothelial tube lumen extension; negative regulation of cell migration involved in sprouting angiogenesis; and negative regulation of sprouting angiogenesis. Predicted to be located in cytoplasm. Orthologous to human STARD13 (StAR related lipid transfer domain containing 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 133.7), Liver (RPKM 88.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stard13 in Genome Data Viewer
    Location:
    12p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (5401878..5797937, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (566282..959372, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (1023494..1418919, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548964 Neighboring gene Klotho Neighboring gene transfer RNA proline (anticodon AGG) 21 Neighboring gene uncharacterized LOC134481141 Neighboring gene uncharacterized LOC102549089 Neighboring gene uncharacterized LOC134481142 Neighboring gene vomeronasal 2 receptor, pseudogene 97 Neighboring gene replication factor C subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene. Ren X, et al. PLoS One, 2013. PMID 24023717, Free PMC Article
    2. DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Lin Y, et al. Oncogene, 2010 May 20. PMID 20208559, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT acts_upstream_of_or_within angiogenesis involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endothelial tube lumen extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 13
    Names
    StAR-related lipid transfer (START) domain containing 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109060.1 → NP_001102530.1  stAR-related lipid transfer protein 13

      See identical proteins and their annotated locations for NP_001102530.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474108
      UniProtKB/TrEMBL
      A6KSV7, T2C9V6, T2CBG9
      Conserved Domains (4) summary
      cd08909
      Location:900 → 1103
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09592
      Location:57 → 120
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:61 → 120
      SAM; Sterile alpha motif
      cd04375
      Location:656 → 873
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      5401878..5797937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598426.3 → XP_017453915.1  stAR-related lipid transfer protein 13 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AGG1

    2. XM_017598424.3 → XP_017453913.1  stAR-related lipid transfer protein 13 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AGG1

    3. XM_063271572.1 → XP_063127642.1  stAR-related lipid transfer protein 13 isoform X5

      Related
      ENSRNOP00000091607.2, ENSRNOT00000118613.2

    4. XM_017598429.3 → XP_017453918.1  stAR-related lipid transfer protein 13 isoform X3

    5. XM_017598428.3 → XP_017453917.1  stAR-related lipid transfer protein 13 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AFY2
      Related
      ENSRNOP00000091608.1, ENSRNOT00000094162.2

    6. XM_006248743.5 → XP_006248805.1  stAR-related lipid transfer protein 13 isoform X1

      UniProtKB/TrEMBL
      D3ZU63
      Related
      ENSRNOP00000001446.6, ENSRNOT00000001446.7
      Conserved Domains (4) summary
      cd08909
      Location:919 → 1122
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09592
      Location:57 → 120
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:61 → 120
      SAM; Sterile alpha motif
      cd04375
      Location:675 → 892
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

    7. XM_039089673.2 → XP_038945601.1  stAR-related lipid transfer protein 13 isoform X9

      Conserved Domains (2) summary
      cd08909
      Location:743 → 946
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:499 → 716
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    8. XM_063271573.1 → XP_063127643.1  stAR-related lipid transfer protein 13 isoform X8

    9. XM_039089672.2 → XP_038945600.1  stAR-related lipid transfer protein 13 isoform X6

      Conserved Domains (2) summary
      cd08909
      Location:801 → 1004
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:557 → 774
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    10. XM_006248749.5 → XP_006248811.1  stAR-related lipid transfer protein 13 isoform X6

      See identical proteins and their annotated locations for XP_006248811.1

      Conserved Domains (2) summary
      cd08909
      Location:801 → 1004
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:557 → 774
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    11. XM_008768991.3 → XP_008767213.1  stAR-related lipid transfer protein 13 isoform X7

      Conserved Domains (2) summary
      cd08909
      Location:793 → 996
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:549 → 766
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

    12. XM_039089674.2 → XP_038945602.1  stAR-related lipid transfer protein 13 isoform X10

      Conserved Domains (2) summary
      cd09592
      Location:57 → 120
      SAM_DLC2; SAM domain of STARD13-like subfamily
      cl02570
      Location:675 → 704
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    Nucleotide Protein Strain
    Heading Accession and Version

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