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    Rad18 RAD18 E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362412, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rad18provided by RGD
    Official Full Name
    RAD18 E3 ubiquitin protein ligaseprovided by RGD
    Primary source
    RGD:1306993
    See related
    EnsemblRapid:ENSRNOG00000005907 AllianceGenome:RGD:1306993
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including Y-form DNA binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of chromosome segregation; postreplication repair; and protein monoubiquitination. Predicted to act upstream of or within several processes, including negative regulation of DNA recombination; protein autoubiquitination; and response to UV. Predicted to be located in centrosome; chromosome; and nucleus. Predicted to be part of Rad6-Rad18 complex. Predicted to be active in nucleus. Orthologous to human RAD18 (RAD18 E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 140.0), Thymus (RPKM 68.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad18 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (147291463..147376904, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (145735654..145821102, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (144537329..144620606, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene caveolin 3 Neighboring gene oxytocin receptor Neighboring gene uncharacterized LOC102548080 Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A natural antisense transcript against Rad18, specifically expressed in neurons and upregulated during beta-amyloid-induced apoptosis. Parenti R, et al. Eur J Neurosci, 2007 Nov. PMID 17970741
    2. Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. Sun J, et al. Mech Dev, 2009 Mar-Apr. PMID 19068231
    3. Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18. van der Laan R, et al. Genomics, 2000 Oct 1. PMID 11013078
    4. Formation of D-serine from L-phosphoserine in brain synaptosomes. Wood PL, et al. J Neurochem, 1996 Oct. PMID 8858931
    5. Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells. Tateishi S, et al. Mol Cell Biol, 2003 Jan. PMID 12509447, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These experiments suggest the existence of a natural antisense transcript (NAT) that exerts a post-transcriptional control over Rad18.
      Title: A natural antisense transcript against Rad18, specifically expressed in neurons and upregulated during beta-amyloid-induced apoptosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156682

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Y-form DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad6-Rad18 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in XY body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RAD18
    Names
    RAD18 homolog
    NP_001071141.1
    XP_006237098.1
    XP_006237099.1
    XP_063142360.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077673.1 → NP_001071141.1  E3 ubiquitin-protein ligase RAD18

      See identical proteins and their annotated locations for NP_001071141.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127510
      UniProtKB/TrEMBL
      A0A8I5YBD2, A0JPN0
      Related
      ENSRNOP00000063400.1, ENSRNOT00000066468.4
      Conserved Domains (4) summary
      smart00734
      Location:201 → 224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:25 → 63
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13 → 363
      rad18; DNA repair protein rad18
      pfam02037
      Location:248 → 282
      SAP; SAP domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      147291463..147376904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286290.1 → XP_063142360.1  E3 ubiquitin-protein ligase RAD18 isoform X3

      Related
      ENSRNOP00000076533.2, ENSRNOT00000099439.2

    2. XM_006237036.4 → XP_006237098.1  E3 ubiquitin-protein ligase RAD18 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBD2
      Conserved Domains (4) summary
      smart00734
      Location:201 → 224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:25 → 63
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13 → 363
      rad18; DNA repair protein rad18
      pfam02037
      Location:248 → 282
      SAP; SAP domain

    3. XM_006237037.4 → XP_006237099.1  E3 ubiquitin-protein ligase RAD18 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKR5, A6IBN3
      Related
      ENSRNOP00000094440.1, ENSRNOT00000115978.2
      Conserved Domains (4) summary
      smart00734
      Location:201 → 224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:25 → 63
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13 → 363
      rad18; DNA repair protein rad18
      pfam02037
      Location:248 → 282
      SAP; SAP domain
    Nucleotide Protein Strain
    Heading Accession and Version

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