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    Zfp536 zinc finger protein 536 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292820, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp536provided by RGD
    Official Full Name
    zinc finger protein 536provided by RGD
    Primary source
    RGD:1563363
    See related
    EnsemblRapid:ENSRNOG00000014163 AllianceGenome:RGD:1563363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf536; RGD1563363
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and retinoic acid-responsive element binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of neuron differentiation and negative regulation of retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Orthologous to human ZNF536 (zinc finger protein 536). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 38.0), Adrenal (RPKM 18.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp536 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (99137133..99600379, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (90000359..90463423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (93689114..94155457, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27A like 3 Neighboring gene uncharacterized LOC134484891 Neighboring gene uncharacterized LOC108349103 Neighboring gene histidine-rich glycoprotein-like Neighboring gene uncharacterized LOC134485112 Neighboring gene U6 spliceosomal RNA Neighboring gene URI1, prefoldin-like chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Qin Z, et al. Mol Cell Biol, 2009 Jul. PMID 19398580, Free PMC Article
    2. Functional genomic analysis of oligodendrocyte differentiation. Dugas JC, et al. J Neurosci, 2006 Oct 25. PMID 17065439, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFP536 promotes the late phase of oligodendrocyte differentiation
      Title: Functional genomic analysis of oligodendrocyte differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid-responsive element binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 536

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427135.1 → NP_001414064.1  zinc finger protein 536

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZJS6
      Related
      ENSRNOP00000108656.1, ENSRNOT00000165203.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      99137133..99600379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283757.1 → XP_063139827.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6

    2. XM_008759270.4 → XP_008757492.2  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    3. XM_063283740.1 → XP_063139810.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6

    4. XM_063283747.1 → XP_063139817.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6

    5. XM_063283750.1 → XP_063139820.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6

    6. XM_063283762.1 → XP_063139832.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6

    7. XM_008759271.4 → XP_008757493.2  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    8. XM_008759269.4 → XP_008757491.2  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    9. XM_039100867.2 → XP_038956795.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      D3ZJS6
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    10. XM_063283777.1 → XP_063139847.1  zinc finger protein 536 isoform X3

      Related
      ENSRNOP00000103138.1, ENSRNOT00000147133.1

    11. XM_063283767.1 → XP_063139837.1  zinc finger protein 536 isoform X2

    12. XM_063283764.1 → XP_063139834.1  zinc finger protein 536 isoform X2

    13. XM_063283773.1 → XP_063139843.1  zinc finger protein 536 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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