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    Rad54l RAD54 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298429, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Rad54lprovided by RGD
    Official Full Name
    RAD54 likeprovided by RGD
    Primary source
    RGD:1310600
    See related
    EnsemblRapid:ENSRNOG00000013148 AllianceGenome:RGD:1310600
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP-dependent DNA/DNA annealing activity; ATP-dependent chromatin remodeler activity; and transcription coregulator activity. Predicted to be involved in chromatin organization. Predicted to act upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Thymus (RPKM 79.1), Spleen (RPKM 48.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad54l in Genome Data Viewer
    Location:
    5q35
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134812158..134841821, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129575431..129605100, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134948511..134978125, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene uncharacterized LOC134486970 Neighboring gene leucine rich repeat containing 41 Neighboring gene uncharacterized LOC134486969 Neighboring gene leucine rich adaptor protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the RAD54 recombination gene in primary cancers. Matsuda M, et al. Oncogene, 1999 Jun 3. PMID 10362365
    2. Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Mills KD, et al. Genes Dev, 2004 Jun 1. PMID 15175260, Free PMC Article
    3. Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation. Li Z, et al. PLoS One, 2024. PMID 38593124, Free PMC Article
    4. Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair. Kirshner M, et al. DNA Repair (Amst), 2009 Feb 1. PMID 19061978
    5. Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Wang H, et al. Nucleic Acids Res, 2010 Jun. PMID 20150414, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1alpha/VEGF signaling pathway: Bioinformatics analysis and experimental validation.
      Title: Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189414

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair and recombination protein RAD54-like
    NP_001128432.1
    XP_038965522.1
    XP_063143472.1
    XP_063143473.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134960.1 → NP_001128432.1  DNA repair and recombination protein RAD54-like

      See identical proteins and their annotated locations for NP_001128432.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169034
      UniProtKB/TrEMBL
      A0A8I6AKM5, B5DFE8
      Conserved Domains (4) summary
      cd00046
      Location:177 → 327
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:490 → 619
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:156 → 463
      SNF2_N; SNF2 family N-terminal domain
      pfam08658
      Location:74 → 123
      Rad54_N; Rad54 N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      134812158..134841821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287402.1 → XP_063143472.1  DNA repair and recombination protein RAD54-like isoform X1

      UniProtKB/TrEMBL
      B5DFE8
      Related
      ENSRNOP00000018004.7, ENSRNOT00000018004.7

    2. XM_039109594.1 → XP_038965522.1  DNA repair and recombination protein RAD54-like isoform X2

      Conserved Domains (2) summary
      cd18067
      Location:153 → 395
      DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
      pfam08658
      Location:76 → 123
      Rad54_N; Rad54 N terminal

    3. XM_063287403.1 → XP_063143473.1  DNA repair and recombination protein RAD54-like isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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