Adgrf4 adhesion G protein-coupled receptor F4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adgrf4provided by RGD
Official Full Name: adhesion G protein-coupled receptor F4provided by RGD
Primary source: RGD:1565216
See related: EnsemblRapid:ENSRNOG00000012535 AllianceGenome:RGD:1565216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr115; RGD1565216
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within erythrocyte development; glomerular filtration; and pharyngeal arch artery morphogenesis. Predicted to be located in membrane. Orthologous to human ADGRF4 (adhesion G protein-coupled receptor F4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 5.4), Muscle (RPKM 0.8) and 1 other tissue See more
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Genomic context

Location:: 9q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (25769265..25800438)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (18272050..18303219)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (20951249..20982493)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D9Rat34 (e-PCR)
- UniSTS:119172

RH128548 (e-PCR)
- UniSTS:211856

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glomerular filtration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor F4

Names: G protein-coupled receptor 115

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399351.1 → NP_001386280.1 adhesion G protein-coupled receptor F4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

D3ZTY4

Related

ENSRNOP00000016906.3, ENSRNOT00000016906.7

Conserved Domains (2) summary

cd15994
Location:402 → 669

7tmB2_GPR111_115; orphan adhesion receptors GPR111 and GPR115, member of the class B2 family of seven-transmembrane G protein-coupled receptors

cl02559
Location:349 → 400

GPS; GPCR proteolysis site, GPS, motif