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    Slc17a4 solute carrier family 17, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679784, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc17a4provided by RGD
    Official Full Name
    solute carrier family 17, member 4provided by RGD
    Primary source
    RGD:1584758
    See related
    EnsemblRapid:ENSRNOG00000022505 AllianceGenome:RGD:1584758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable thyroid hormone transmembrane transporter activity and urate transmembrane transporter activity. Predicted to be involved in monoatomic anion transport and sodium-dependent phosphate transport. Predicted to be located in brush border membrane. Predicted to be active in apical plasma membrane. Orthologous to human SLC17A4 (solute carrier family 17 member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 83.3) and Kidney (RPKM 39.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc17a4 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41629417..41646623)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41201546..41218752)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43452316..43472192)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909739 Neighboring gene H2A clustered histone 1 Neighboring gene H2B clustered histone 1 Neighboring gene solute carrier family 17 member 1 Neighboring gene uncharacterized LOC134482855 Neighboring gene solute carrier family 17 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables thyroid hormone transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium-dependent phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium-dependent phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable small intestine urate exporter
    Names
    solute carrier family 17 (sodium phosphate), member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271214.1 → NP_001258143.1  probable small intestine urate exporter

      See identical proteins and their annotated locations for NP_001258143.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2JXU5, A6KLJ0
      Related
      ENSRNOP00000056253.5, ENSRNOT00000059494.6
      Conserved Domains (1) summary
      cd17318
      Location:40 → 479
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      41629417..41646623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771658.3 → XP_008769880.1  probable small intestine urate exporter isoform X1

      See identical proteins and their annotated locations for XP_008769880.1

      UniProtKB/TrEMBL
      A0A0G2JXU5, A6KLJ0
      Related
      ENSRNOP00000070406.1, ENSRNOT00000088939.3
      Conserved Domains (1) summary
      cd17318
      Location:40 → 479
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    2. XM_039096055.1 → XP_038951983.1  probable small intestine urate exporter isoform X2

      UniProtKB/TrEMBL
      D3ZX83
      Conserved Domains (1) summary
      cl28910
      Location:40 → 401
      MFS; Major Facilitator Superfamily

    3. XM_039096054.2 → XP_038951982.1  probable small intestine urate exporter isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXU5, A6KLJ0
      Conserved Domains (1) summary
      cd17318
      Location:40 → 479
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    4. XM_008771659.4 → XP_008769881.1  probable small intestine urate exporter isoform X1

      See identical proteins and their annotated locations for XP_008769881.1

      UniProtKB/TrEMBL
      A0A0G2JXU5, A6KLJ0
      Conserved Domains (1) summary
      cd17318
      Location:40 → 479
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    5. XM_039096056.1 → XP_038951984.1  probable small intestine urate exporter isoform X3

      Conserved Domains (1) summary
      TIGR00894
      Location:12 → 293
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein Strain
    Heading Accession and Version

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