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    Incenp inner centromere protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293733, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Incenpprovided by RGD
    Official Full Name
    inner centromere proteinprovided by RGD
    Primary source
    RGD:1305292
    See related
    EnsemblRapid:ENSRNOG00000032929 AllianceGenome:RGD:1305292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular function activator activity. Predicted to be involved in meiotic spindle midzone assembly; metaphase chromosome alignment; and mitotic cytokinesis. Predicted to be located in several cellular components, including chromocenter; nuclear lumen; and pericentric heterochromatin. Predicted to be part of chromosome passenger complex. Predicted to be active in several cellular components, including kinetochore; meiotic spindle midzone; and midbody. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 127.6), Spleen (RPKM 95.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Incenp in Genome Data Viewer
    Location:
    1q43
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215945558..216017247, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206520655..206550575, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225923448..225953384, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene secretoglobin, family 1D, member 2, pseudogene 1 Neighboring gene secretoglobin, family 2A, member 1 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, pseudogene 1 Neighboring gene ferritin heavy chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. Ainsztein AM, et al. J Cell Biol, 1998 Dec 28. PMID 9864353, Free PMC Article
    2. Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. Vader G, et al. EMBO Rep, 2006 Jan. PMID 16239925, Free PMC Article
    3. Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Qi W, et al. Mol Biol Cell, 2006 Aug. PMID 16760428, Free PMC Article
    4. Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis. Parra MT, et al. J Cell Sci, 2003 Mar 15. PMID 12584241
    5. Sequential assembly of centromeric proteins in male mouse meiosis. Parra MT, et al. PLoS Genet, 2009 Mar. PMID 19283064, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in central element ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromocenter ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromosome passenger complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral element ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in meiotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inner centromere protein
    Names
    inner centromere protein antigens 135/155kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106335.1 → NP_001099805.1  inner centromere protein

      See identical proteins and their annotated locations for NP_001099805.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6I000, D3ZXY1
      Related
      ENSRNOP00000047950.4, ENSRNOT00000043387.5
      Conserved Domains (4) summary
      pfam03941
      Location:815 → 866
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:6 → 41
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cd16269
      Location:601 → 612
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:528 → 632
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215945558..216017247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286935.1 → XP_063143005.1  inner centromere protein isoform X3

    2. XM_063286932.1 → XP_063143002.1  inner centromere protein isoform X2

    3. XM_006231025.3 → XP_006231087.1  inner centromere protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZP23, A0A8I5ZZ56
      Related
      ENSRNOP00000080126.1, ENSRNOT00000096008.2
      Conserved Domains (4) summary
      pfam03941
      Location:839 → 890
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:30 → 65
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cd16269
      Location:625 → 636
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:552 → 656
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. XM_063286938.1 → XP_063143008.1  inner centromere protein isoform X3

      UniProtKB/TrEMBL
      A6I000

    5. XM_063286940.1 → XP_063143010.1  inner centromere protein isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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