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    Brox BRO1 domain and CAAX motif containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305031, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Broxprovided by RGD
    Official Full Name
    BRO1 domain and CAAX motif containingprovided by RGD
    Primary source
    RGD:1307161
    See related
    EnsemblRapid:ENSRNOG00000052963 AllianceGenome:RGD:1307161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307161
    Summary
    Predicted to be involved in mitotic nuclear membrane reassembly. Predicted to be located in nuclear envelope. Orthologous to human BROX (BRO1 domain and CAAX motif containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 186.5), Heart (RPKM 184.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Brox in Genome Data Viewer
    Location:
    13q26
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (97451736..97471598, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94920107..94940189, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101677896..101697743, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member B Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene axin interactor, dorsalization associated Neighboring gene uncharacterized LOC120096334 Neighboring gene uncharacterized LOC120096335

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114362

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitotic nuclear membrane reassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic nuclear membrane reassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BRO1 domain-containing protein BROX
    Names
    BRO1 domain- and CAAX motif-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025669.1 → NP_001020840.1  BRO1 domain-containing protein BROX

      See identical proteins and their annotated locations for NP_001020840.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097348
      UniProtKB/Swiss-Prot
      Q4V8K5
      UniProtKB/TrEMBL
      A0A8I6ACA4, A6JGN3
      Related
      ENSRNOP00000073617.1, ENSRNOT00000078834.3
      Conserved Domains (1) summary
      cd09243
      Location:4 → 356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      97451736..97471598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250354.5 → XP_006250416.1  BRO1 domain-containing protein BROX isoform X2

      Conserved Domains (1) summary
      cl14649
      Location:4 → 288
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

    2. XM_063272389.1 → XP_063128459.1  BRO1 domain-containing protein BROX isoform X2

    3. XM_017598835.3 → XP_017454324.1  BRO1 domain-containing protein BROX isoform X1

      UniProtKB/Swiss-Prot
      Q4V8K5
      UniProtKB/TrEMBL
      A0A8I6ACA4, A6JGN3
      Conserved Domains (1) summary
      cd09243
      Location:4 → 356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8K5.1 GenPept UniProtKB/Swiss-Prot:Q4V8K5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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