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    Ipmk inositol polyphosphate multikinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171458, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ipmkprovided by RGD
    Official Full Name
    inositol polyphosphate multikinaseprovided by RGD
    Primary source
    RGD:620954
    See related
    EnsemblRapid:ENSRNOG00000000609 AllianceGenome:RGD:620954
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Impk; Ipk2
    Summary
    Enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity and inositol phosphate kinase activity. Predicted to be involved in inositol phosphate biosynthetic process; inositol trisphosphate metabolic process; and necroptotic process. Predicted to act upstream of or within neural tube formation. Located in nucleus. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 167.5), Lung (RPKM 48.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ipmk in Genome Data Viewer
    Location:
    20p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (17216151..17250826, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (17216988..17251675, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (18457309..18489884, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483788 Neighboring gene uncharacterized LOC102547881 Neighboring gene ribosomal protein L39, pseudogene 14 Neighboring gene CDGSH iron sulfur domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate. Saiardi A, et al. Proc Natl Acad Sci U S A, 2001 Feb 27. PMID 11226235, Free PMC Article
    2. An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production. Frederick JP, et al. Proc Natl Acad Sci U S A, 2005 Jun 14. PMID 15939867, Free PMC Article
    3. Dvl3 translocates IPMK to the cell membrane in response to Wnt. Wang Y, et al. Cell Signal, 2012 Dec. PMID 22940627, Free PMC Article
    4. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. Gu C, et al. J Med Chem, 2019 Feb 14. PMID 30624931, Free PMC Article
    5. Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Resnick AC, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16123124, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Translocation of IPMK to plasma membrane via docking Dvl3 is important for IPMK to access substrates and generate IP5, activating down-stream signaling.
      Title: Dvl3 translocates IPMK to the cell membrane in response to Wnt.
    2. IPK2 and IPK1 act as key determining steps in production of IP5 and IP6, respectively
      Title: A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavonoid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol tetrakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,4,5-trisphosphate 6-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inositol trisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in necroptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in necroptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neural tube formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inositol polyphosphate multikinase
    Names
    inositol 1,3,4,6-tetrakisphosphate 5-kinase
    inositol polyphosphate kinase 2
    NP_599244.1
    XP_006256407.1
    XP_006256408.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134417.2 → NP_599244.1  inositol polyphosphate multikinase

      See identical proteins and their annotated locations for NP_599244.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q99NI4
      UniProtKB/TrEMBL
      A0A8I6AI58, A6JKN6
      Related
      ENSRNOP00000093022.2, ENSRNOT00000105838.2
      Conserved Domains (1) summary
      pfam03770
      Location:110 → 391
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      17216151..17250826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256345.5 → XP_006256407.1  inositol polyphosphate multikinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI58, A0A8L2PZ63
      Related
      ENSRNOP00000000748.3, ENSRNOT00000000748.5
      Conserved Domains (1) summary
      pfam03770
      Location:111 → 392
      IPK; Inositol polyphosphate kinase

    2. XM_006256346.5 → XP_006256408.1  inositol polyphosphate multikinase isoform X2

      UniProtKB/TrEMBL
      A0A8I6AI58
      Conserved Domains (1) summary
      pfam03770
      Location:69 → 350
      IPK; Inositol polyphosphate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NI4.1 GenPept UniProtKB/Swiss-Prot:Q99NI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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