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    Mcm2 minichromosome maintenance complex component 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312538, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Mcm2provided by RGD
    Official Full Name
    minichromosome maintenance complex component 2provided by RGD
    Primary source
    RGD:1305577
    See related
    EnsemblRapid:ENSRNOG00000016316 AllianceGenome:RGD:1305577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity; enzyme binding activity; and histone binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in several processes, including DNA-dependent DNA replication; cochlea development; and double-strand break repair via break-induced replication. Predicted to act upstream of or within cellular response to interleukin-4 and nucleosome assembly. Located in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 288.6), Spleen (RPKM 187.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcm2 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (122903679..122918205, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121346434..121360962, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120825699..120840221, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene podocalyxin-like 2 Neighboring gene transmembrane protein adipocyte associated 1 Neighboring gene uncharacterized LOC102554942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Bonda DJ, et al. Aging (Albany NY), 2009 Apr. PMID 19946466, Free PMC Article
    2. Age-dependent impairment of hippocampal neurogenesis in chronic cerebral hypoperfusion. Sivilia S, et al. Neuropathol Appl Neurobiol, 2008 Feb. PMID 17931356
    3. Whole Exome Sequencing Identified MCM2 as a Novel Causative Gene for Autosomal Dominant Nonsyndromic Deafness in a Chinese Family. Gao J, et al. PLoS One, 2015. PMID 26196677, Free PMC Article
    4. Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Zhang C, et al. Exp Neurol, 2007 Mar. PMID 17070803, Free PMC Article
    5. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. Chen JF, et al. J Neurosci, 1999 Nov 1. PMID 10531422, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interleukin-4 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cochlea development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM2
    Names
    minichromosome maintenance deficient 2 mitotin
    NP_001101343.2
    XP_006236925.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107873.2 → NP_001101343.2  DNA replication licensing factor MCM2

      See identical proteins and their annotated locations for NP_001101343.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D3ZP96
      Related
      ENSRNOP00000022231.5, ENSRNOT00000022231.8
      Conserved Domains (4) summary
      smart00350
      Location:292 → 804
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:73 → 183
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:199 → 311
      MCM_N; MCM N-terminal domain
      cl21455
      Location:486 → 633
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      122903679..122918205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236863.3 → XP_006236925.1  DNA replication licensing factor MCM2 isoform X1

      See identical proteins and their annotated locations for XP_006236925.1

      UniProtKB/TrEMBL
      D3ZP96
      Conserved Domains (4) summary
      smart00350
      Location:292 → 804
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:73 → 183
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:199 → 311
      MCM_N; MCM N-terminal domain
      cl21455
      Location:486 → 633
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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