Hint3 histidine triad nucleotide binding protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hint3provided by RGD
Official Full Name: histidine triad nucleotide binding protein 3provided by RGD
Primary source: RGD:621603
See related: Ensembl:ENSRNOG00000014190 AllianceGenome:RGD:621603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hint4; HINT-3; HINT-4
Summary: Predicted to enable adenosine 5'-monophosphoramidase activity and identical protein binding activity. Predicted to be located in cytoplasm and nucleus. Orthologous to human HINT3 (histidine triad nucleotide binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 132.4), Liver (RPKM 130.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (28854860..28864723)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (27035936..27045799)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (29413425..29423288)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	IEA Inferred from Electronic Annotation more info
enables adenosine 5'-monophosphoramidase activity	ISO Inferred from Sequence Orthology more info
enables adenosine 5'-monophosphoramidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adenosine 5'-monophosphoramidase HINT3

Names: histidine triad nucleotide binding protein 4

NP_001094295.1

EC 3.-.-.-

NP_001263362.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100825.1 → NP_001094295.1 adenosine 5'-monophosphoramidase HINT3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CB741212, JAXUCZ010000001

UniProtKB/Swiss-Prot

Q8K3P7

UniProtKB/TrEMBL

F1M9G8

Related

ENSRNOP00000019047.5, ENSRNOT00000019047.8

Conserved Domains (1) summary

cd01278
Location:40 → 143

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...
NM_001276433.1 → NP_001263362.1 adenosine 5'-monophosphoramidase HINT3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K7W8, A0A8I5Y9H6

Related

ENSRNOP00000074377.1, ENSRNOT00000088885.2

Conserved Domains (1) summary

cl00228
Location:40 → 124

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...