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    Tfap4 transcription factor AP-4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360482, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Tfap4provided by RGD
    Official Full Name
    transcription factor AP-4provided by RGD
    Primary source
    RGD:1308357
    See related
    EnsemblRapid:ENSRNOG00000005227 AllianceGenome:RGD:1308357
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tcfap4
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of macromolecule metabolic process; and regulation of transcription, DNA-templated. Predicted to act upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 12.8), Spleen (RPKM 12.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11507242..11525794)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11001338..11019386)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11204616..11222975)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095029 Neighboring gene presequence translocase associated motor 16 Neighboring gene GLIS family zinc finger 2 Neighboring gene uncharacterized LOC120095030 Neighboring gene uncharacterized LOC134480651 Neighboring gene sarcalumenin Neighboring gene uncharacterized LOC134480754

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene. Cheng CK, et al. Mol Endocrinol, 2003 Jul. PMID 12663744
    2. Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. Aranburu A, et al. Biochem J, 2001 Mar 1. PMID 11171123, Free PMC Article
    3. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Hu YF, et al. Genes Dev, 1990 Oct. PMID 2123466
    4. Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. Tsujimoto K, et al. J Biol Chem, 2005 Jul 29. PMID 15944155
    5. AP4 encodes a c-MYC-inducible repressor of p21. Jung P, et al. Proc Natl Acad Sci U S A, 2008 Sep 30. PMID 18818310, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to dexamethasone stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation by host of viral transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor AP-4
    Names
    transcription factor AP-4 (activating enhancer binding protein 4)
    transcription factor AP4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108267.2 → NP_001101737.1  transcription factor AP-4

      See identical proteins and their annotated locations for NP_001101737.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6K4S7, D3ZJT6
      Related
      ENSRNOP00000006979.5, ENSRNOT00000006979.9
      Conserved Domains (1) summary
      cd11419
      Location:46 → 106
      bHLHzip_TFAP4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11507242..11525794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086267.2 → XP_038942195.1  transcription factor AP-4 isoform X1

      Conserved Domains (1) summary
      cd11419
      Location:46 → 106
      bHLHzip_TFAP4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins

    2. XM_006245819.5 → XP_006245881.1  transcription factor AP-4 isoform X2

      See identical proteins and their annotated locations for XP_006245881.1

      Conserved Domains (1) summary
      cl00081
      Location:1 → 46
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    3. XM_017597365.3 → XP_017452854.1  transcription factor AP-4 isoform X2

      Related
      ENSRNOP00000100833.1, ENSRNOT00000125715.1
      Conserved Domains (1) summary
      cl00081
      Location:1 → 46
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    4. XM_006245822.5 → XP_006245884.1  transcription factor AP-4 isoform X2

      See identical proteins and their annotated locations for XP_006245884.1

      Conserved Domains (1) summary
      cl00081
      Location:1 → 46
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    5. XM_039086268.2 → XP_038942196.1  transcription factor AP-4 isoform X2

      Conserved Domains (1) summary
      cl00081
      Location:1 → 46
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    6. XM_006245823.5 → XP_006245885.1  transcription factor AP-4 isoform X2

      See identical proteins and their annotated locations for XP_006245885.1

      Conserved Domains (1) summary
      cl00081
      Location:1 → 46
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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