C5AR1 complement C5a receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: C5AR1provided by HGNC
Official Full Name: complement C5a receptor 1provided by HGNC
Primary source: HGNC:HGNC:1338
See related: Ensembl:ENSG00000197405 MIM:113995; AllianceGenome:HGNC:1338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C5A; C5AR; C5R1; CD88
Summary: Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer's disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in appendix (RPKM 41.3), bone marrow (RPKM 38.2) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (47307477..47322066)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (50129142..50147539)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (47813118..47825323)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages.
Title: Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages.
C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis.
Title: C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8[+] T cell activity.
Title: Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients.
Title: Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients.
Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing.
Title: Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing.
The C5aR1 complement receptor: A novel immunomodulator of insulin action in skeletal muscle.
Title: The C5aR1 complement receptor: A novel immunomodulator of insulin action in skeletal muscle.
C5a enhances inflammation and chemotaxis of gammadelta T cells in malignant pleural effusion.
Title: C5a enhances inflammation and chemotaxis of γδ T cells in malignant pleural effusion.
Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
Title: Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
Title: Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
C5a enhances Vdelta1 T cells recruitment via the CCL2-CCR2 axis in IgA nephropathy.
Title: C5a enhances Vδ1 T cells recruitment via the CCL2-CCR2 axis in IgA nephropathy.

Submit: New GeneRIF Correction See all GeneRIFs (144)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association scan for chronic periodontitis implicates novel locus. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infectivity involves C5AR1 in complex with CCR5 on THP-1 and monocyte-derived macrophages as shown through decreased CCR5-tropic provirus genomic integration in the presence of neutralizing C5aR1 antibody or siRNA or hC5a	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Interaction of HIV-1 gp120 with CD4 is sufficient to trigger a marked reduction in C5a Receptor and a modest reduction in FMLP Receptor on monocytes	PubMed
Nef	nef	Stable expression of HIV-1 Nef induces the upregulated expression of CD88 (complement receptor C5a)	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of complement component 5a receptor 1 (C5AR1) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:185765 (e-PCR)
- UniSTS:155463

C5R1_STS1 (e-PCR)
- UniSTS:275882

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables complement component C5a receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C5a receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in astrocyte activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular defense response	TAS Traceable Author Statement more info	PubMed
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in cognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in complement component C5a signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in microglial cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in presynapse organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to peptidoglycan	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of chemical stimulus	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C5a anaphylatoxin chemotactic receptor 1

Names: C5a anaphylatoxin receptor; C5a ligand; C5a-R; complement component 5a receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001736.4 → NP_001727.2 C5a anaphylatoxin chemotactic receptor 1

Status: VALIDATED

Source sequence(s)

AC099491

Consensus CDS

CCDS33063.1

UniProtKB/Swiss-Prot

P21730

Related

ENSP00000347197.2, ENST00000355085.4

Conserved Domains (1) summary

cd15114
Location:38 → 311

7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

47307477..47322066

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439300.1 → XP_047295256.1 C5a anaphylatoxin chemotactic receptor 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

50129142..50147539

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321907.1 → XP_054177882.1 C5a anaphylatoxin chemotactic receptor 1 isoform X2
XM_054321906.1 → XP_054177881.1 C5a anaphylatoxin chemotactic receptor 1 isoform X1
XM_054321908.1 → XP_054177883.1 C5a anaphylatoxin chemotactic receptor 1 isoform X3