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    ZMAT2 zinc finger matrin-type 2 [ Homo sapiens (human) ]

    Gene ID: 153527, updated on 3-Nov-2024

    Summary

    Official Symbol
    ZMAT2provided by HGNC
    Official Full Name
    zinc finger matrin-type 2provided by HGNC
    Primary source
    HGNC:HGNC:26433
    See related
    Ensembl:ENSG00000146007 MIM:619930; AllianceGenome:HGNC:26433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Snu23; Ptg-12
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 45.9), fat (RPKM 34.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZMAT2 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (140700447..140706686)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (141225840..141232080)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140080032..140086271)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140052831-140053626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23284 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23285 Neighboring gene HARS1 and HARS2 bidirectional promoter region Neighboring gene histidyl-tRNA synthetase 2, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23288 Neighboring gene NANOG hESC enhancer GRCh37_chr5:140082322-140082864 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:140090124-140091323 Neighboring gene uncharacterized LOC105378198 Neighboring gene vault RNA 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23290 Neighboring gene vault RNA 1-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Clone Names

    • FLJ31121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    enables protein binding PubMed 
    enables zinc ion binding  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome PubMed 
    part_of U4/U6 x U5 tri-snRNP complex  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    zinc finger matrin-type protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144723.3NP_653324.1  zinc finger matrin-type protein 2

      See identical proteins and their annotated locations for NP_653324.1

      Status: VALIDATED

      Source sequence(s)
      AA071274, AC116353, AK055683
      Consensus CDS
      CCDS4239.1
      UniProtKB/Swiss-Prot
      Q96NC0
      Related
      ENSP00000274712.2, ENST00000274712.8
      Conserved Domains (2) summary
      smart00451
      Location:77108
      ZnF_U1; U1-like zinc finger
      pfam08648
      Location:178196
      DUF1777; Protein of unknown function (DUF1777)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      140700447..140706686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      141225840..141232080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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