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    LYPD8 LY6/PLAUR domain containing 8 [ Homo sapiens (human) ]

    Gene ID: 646627, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LYPD8provided by HGNC
    Official Full Name
    LY6/PLAUR domain containing 8provided by HGNC
    Primary source
    HGNC:HGNC:44208
    See related
    Ensembl:ENSG00000259823 MIM:617067; AllianceGenome:HGNC:44208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward colon (RPKM 65.3) See more
    Orthologs
    mouse all
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    Genomic context

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    See LYPD8 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248739415..248755759, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (248177673..248193983, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248902716..248903170, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 14 subfamily I member 1 Neighboring gene LY6/PLAUR domain containing 9, pseudogene Neighboring gene adenosylhomocysteinase pseudogene 8 Neighboring gene uncharacterized LOC107985747 Neighboring gene DPY19L4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2048 Neighboring gene uncharacterized LOC124904577 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:249096844-249098043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2874

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of IL‑6 and TNF‑α. Xu J, et al. Oncol Rep, 2019 Apr. PMID 30816524
    2. Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease. Hsu CC, et al. Int Immunol, 2021 Jun 18. PMID 33822948
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ly6/PLAUR domain-containing protein 8
    Names
    phospholipase inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085474.2 → NP_001078943.2  ly6/PLAUR domain-containing protein 8 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AEKP01210869, CR589904, FP476111, FP885904
      Consensus CDS
      CCDS73059.1
      UniProtKB/Swiss-Prot
      A0A075B722, K7ELG6, Q6UX82
      Related
      ENSP00000466070.2, ENST00000590317.4

    2. NM_001291283.2 → NP_001278212.2  ly6/PLAUR domain-containing protein 8 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR589904, FP476111, FP885904
      Consensus CDS
      CCDS73059.1
      UniProtKB/Swiss-Prot
      A0A075B722, K7ELG6, Q6UX82

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      248739415..248755759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      248177673..248193983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UX82.2 GenPept UniProtKB/Swiss-Prot:Q6UX82

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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