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    CHST15 carbohydrate sulfotransferase 15 [ Homo sapiens (human) ]

    Gene ID: 51363, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CHST15provided by HGNC
    Official Full Name
    carbohydrate sulfotransferase 15provided by HGNC
    Primary source
    HGNC:HGNC:18137
    See related
    Ensembl:ENSG00000182022 MIM:608277; AllianceGenome:HGNC:18137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRAG; GALNAC4S-6ST
    Summary
    Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 9.9), spleen (RPKM 9.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CHST15 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (124007668..124093598, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (124884870..124970782, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125767184..125853114, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984128 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10754 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_10761 and experimental_10770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125754121-125754683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125754684-125755246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125763289-125763856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125763857-125764422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125765089-125765590 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125779847-125780352 Neighboring gene YBX2 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125780353-125780859 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125785865-125786861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125793037-125793559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125793560-125794081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125808477-125808977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125807976-125808476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125810019-125810519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125816334-125816862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125819356-125820031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125832991-125833492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125833493-125833992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4163 Neighboring gene uncharacterized LOC105378536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4165 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:125927283-125928482 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:125929584-125930147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125936098-125936598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125958373-125958874 Neighboring gene uncharacterized LOC107984184

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk. Chen Y, et al. Cell Death Dis, 2022 Jul 7. PMID 35798703, Free PMC Article
    2. Difference between N-acetylgalactosamine 4-sulfate 6-O-sulfotransferases from human serum and squid cartilage in specificity toward the terminal and interior portion of chondroitin sulfate. Inoue H, et al. J Biol Chem, 1986 Apr 5. PMID 3082866
    3. Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer. Yuki M, et al. Oncol Rep, 2000 Nov-Dec. PMID 11032940
    4. A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase. Ohtake S, et al. J Biol Chem, 2003 Oct 3. PMID 12874280
    5. Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase. Sawada T, et al. Carbohydr Res, 2005 Sep 5. PMID 16024005

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population.
      Title: Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population.
    2. CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk.
      Title: CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk.
    3. circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.
      Title: circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.
    4. Results showed that CHST15 is highly expressed in esophageal squamous cell carcinoma (ESCC) TE1 cell line and tissues. Its knockdown inhibited TE1 cell growth and proliferation, but induced cell apoptosis. These findings indicate that CHST15 may play an essential role in mediating the tumorigenicity of ESCC cells.
      Title: CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer.
    5. The expression of HOTAIR closely correlated with the level of CHST15 protein.
      Title: Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15.
    6. blockade CHST15 represses colonic fibrosis
      Title: Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis.
    7. The direct action of CHST15 on the proliferation.
      Title: Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model.
    8. Findings indicate that GalNAc4S-6ST mRNA expressed by astrocytic tumor cells is associated with poor patient prognosis.
      Title: Role of GalNAc4S-6ST in astrocytic tumor progression.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ60141, KIAA0598, MGC34346, DKFZp781H1369

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in hexose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hexose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 15
    Names
    B cell RAG associated protein (GALNAC4S-6ST)
    B-cell RAG-associated gene protein
    carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
    hBRAG
    NP_001257693.1
    NP_001257694.1
    NP_055678.2
    NP_056976.2
    XP_005269949.1
    XP_005269950.1
    XP_006717954.1
    XP_011538159.1
    XP_016871808.1
    XP_016871809.1
    XP_016871810.1
    XP_047281280.1
    XP_047281281.1
    XP_047281282.1
    XP_047281283.1
    XP_047281284.1
    XP_047281285.1
    XP_047281286.1
    XP_047281287.1
    XP_047281288.1
    XP_047281289.1
    XP_047281290.1
    XP_054222020.1
    XP_054222021.1
    XP_054222022.1
    XP_054222023.1
    XP_054222024.1
    XP_054222025.1
    XP_054222026.1
    XP_054222027.1
    XP_054222028.1
    XP_054222029.1
    XP_054222030.1
    XP_054222031.1
    XP_054222032.1
    XP_054222033.1
    XP_054222034.1
    XP_054222035.1
    XP_054222036.1
    XP_054222037.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032891.1 RefSeqGene

      Range
      5010..90940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270764.2 → NP_001257693.1  carbohydrate sulfotransferase 15 isoform 1

      See identical proteins and their annotated locations for NP_001257693.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and encodes isoform (1). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF026477, BC027908, BC075813, CR749804
      Consensus CDS
      CCDS7638.1
      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4
      UniProtKB/TrEMBL
      B4DH74
      Related
      ENSP00000402394.1, ENST00000435907.6
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family

    2. NM_001270765.2 → NP_001257694.1  carbohydrate sulfotransferase 15 isoform 2

      See identical proteins and their annotated locations for NP_001257694.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AL683842, BC050540, BM977716
      Consensus CDS
      CCDS55731.1
      UniProtKB/TrEMBL
      B4DH74
      Conserved Domains (1) summary
      cl21551
      Location:256 → 407
      Sulfotransfer_3; Sulfotransferase family

    3. NM_014863.4 → NP_055678.2  carbohydrate sulfotransferase 15 isoform 2

      See identical proteins and their annotated locations for NP_055678.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AK294961, AL683842, BM977716
      Consensus CDS
      CCDS55731.1
      UniProtKB/TrEMBL
      B4DH74
      Related
      ENSP00000485905.1, ENST00000628426.1
      Conserved Domains (1) summary
      cl21551
      Location:256 → 407
      Sulfotransfer_3; Sulfotransferase family

    4. NM_015892.5 → NP_056976.2  carbohydrate sulfotransferase 15 isoform 1

      See identical proteins and their annotated locations for NP_056976.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF026477, BC027908, BC075813, BM193389
      Consensus CDS
      CCDS7638.1
      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4
      UniProtKB/TrEMBL
      B4DH74
      Related
      ENSP00000333947.6, ENST00000346248.7
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      124007668..124093598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425324.1 → XP_047281280.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    2. XM_047425327.1 → XP_047281283.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    3. XM_006717891.5 → XP_006717954.1  carbohydrate sulfotransferase 15 isoform X1

      See identical proteins and their annotated locations for XP_006717954.1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4
      UniProtKB/TrEMBL
      B4DH74
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family

    4. XM_047425326.1 → XP_047281282.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    5. XM_047425328.1 → XP_047281284.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    6. XM_017016319.2 → XP_016871808.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4
      UniProtKB/TrEMBL
      B4DH74
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family

    7. XM_047425325.1 → XP_047281281.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    8. XM_005269892.5 → XP_005269949.1  carbohydrate sulfotransferase 15 isoform X2

      UniProtKB/TrEMBL
      B4DH74
      Conserved Domains (1) summary
      cl21551
      Location:253 → 498
      Sulfotransfer_1; Sulfotransferase domain

    9. XM_005269893.4 → XP_005269950.1  carbohydrate sulfotransferase 15 isoform X3

      UniProtKB/TrEMBL
      B4DH74
      Conserved Domains (1) summary
      cl21551
      Location:253 → 498
      Sulfotransfer_1; Sulfotransferase domain

    10. XM_047425330.1 → XP_047281286.1  carbohydrate sulfotransferase 15 isoform X2

    11. XM_017016320.2 → XP_016871809.1  carbohydrate sulfotransferase 15 isoform X2

      UniProtKB/TrEMBL
      B4DH74
      Conserved Domains (1) summary
      cl21551
      Location:253 → 498
      Sulfotransfer_1; Sulfotransferase domain

    12. XM_017016321.2 → XP_016871810.1  carbohydrate sulfotransferase 15 isoform X3

      UniProtKB/TrEMBL
      B4DH74
      Conserved Domains (1) summary
      cl21551
      Location:253 → 498
      Sulfotransfer_1; Sulfotransferase domain

    13. XM_047425331.1 → XP_047281287.1  carbohydrate sulfotransferase 15 isoform X3

    14. XM_047425329.1 → XP_047281285.1  carbohydrate sulfotransferase 15 isoform X2

    15. XM_011539857.2 → XP_011538159.1  carbohydrate sulfotransferase 15 isoform X4

    16. XM_047425334.1 → XP_047281290.1  carbohydrate sulfotransferase 15 isoform X4

    17. XM_047425333.1 → XP_047281289.1  carbohydrate sulfotransferase 15 isoform X4

    18. XM_047425332.1 → XP_047281288.1  carbohydrate sulfotransferase 15 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      124884870..124970782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366046.1 → XP_054222021.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    2. XM_054366050.1 → XP_054222025.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    3. XM_054366045.1 → XP_054222020.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    4. XM_054366049.1 → XP_054222024.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    5. XM_054366047.1 → XP_054222022.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    6. XM_054366051.1 → XP_054222026.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    7. XM_054366048.1 → XP_054222023.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      O60338, O60474, Q7LFX5, Q86VM4

    8. XM_054366052.1 → XP_054222027.1  carbohydrate sulfotransferase 15 isoform X2

    9. XM_054366056.1 → XP_054222031.1  carbohydrate sulfotransferase 15 isoform X3

    10. XM_054366055.1 → XP_054222030.1  carbohydrate sulfotransferase 15 isoform X2

    11. XM_054366053.1 → XP_054222028.1  carbohydrate sulfotransferase 15 isoform X2

    12. XM_054366057.1 → XP_054222032.1  carbohydrate sulfotransferase 15 isoform X3

    13. XM_054366058.1 → XP_054222033.1  carbohydrate sulfotransferase 15 isoform X3

    14. XM_054366054.1 → XP_054222029.1  carbohydrate sulfotransferase 15 isoform X2

    15. XM_054366060.1 → XP_054222035.1  carbohydrate sulfotransferase 15 isoform X4

    16. XM_054366062.1 → XP_054222037.1  carbohydrate sulfotransferase 15 isoform X4

    17. XM_054366061.1 → XP_054222036.1  carbohydrate sulfotransferase 15 isoform X4

    18. XM_054366059.1 → XP_054222034.1  carbohydrate sulfotransferase 15 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7LFX5.1 GenPept UniProtKB/Swiss-Prot:Q7LFX5

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