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    ZNF805 zinc finger protein 805 [ Homo sapiens (human) ]

    Gene ID: 390980, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF805provided by HGNC
    Official Full Name
    zinc finger protein 805provided by HGNC
    Primary source
    HGNC:HGNC:23272
    See related
    Ensembl:ENSG00000204524 AllianceGenome:HGNC:23272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 2.1), spleen (RPKM 1.2) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF805 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57240632..57262728)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60337173..60359201)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57752000..57774096)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15125 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11072 Neighboring gene zinc finger protein 264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11073 Neighboring gene aurora kinase C Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene NANOG hESC enhancer GRCh37_chr19:57774577-57775110 Neighboring gene ZNF460 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11074 Neighboring gene Sharpr-MPRA regulatory region 5355 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:57791112-57792311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15130 Neighboring gene zinc finger protein 460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57814007-57814506 Neighboring gene PPPDE peptidase domain containing 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10022

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Lasky-Su J, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18821565
    2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    3. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Tiemann K, et al. Oncogene, 2019 Apr. PMID 30575818, Free PMC Article
    4. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686P08106

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 805
    Names
    CTC-444N24.8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001023563.4 → NP_001018857.2  zinc finger protein 805 isoform 1

      See identical proteins and their annotated locations for NP_001018857.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC005261
      Consensus CDS
      CCDS46207.1
      UniProtKB/Swiss-Prot
      B4DNM5, Q5CZA5
      Related
      ENSP00000412999.1, ENST00000414468.3
      Conserved Domains (6) summary
      smart00349
      Location:13 → 73
      KRAB; krueppel associated box
      COG5048
      Location:192 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:485 → 505
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:399 → 421
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:13 → 52
      KRAB; KRAB box
      pfam13465
      Location:413 → 438
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001145078.2 → NP_001138550.1  zinc finger protein 805 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC005261, AK297977
      Consensus CDS
      CCDS46208.1
      UniProtKB/Swiss-Prot
      Q5CZA5
      Related
      ENSP00000365414.2, ENST00000354309.4
      Conserved Domains (3) summary
      COG5048
      Location:59 → 435
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:352 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:280 → 305
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57240632..57262728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60337173..60359201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5CZA5.3 GenPept UniProtKB/Swiss-Prot:Q5CZA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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