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    Ganab glucosidase II alpha subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293721, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ganabprovided by RGD
    Official Full Name
    glucosidase II alpha subunitprovided by RGD
    Primary source
    RGD:1309775
    See related
    EnsemblRapid:ENSRNOG00000019724 AllianceGenome:RGD:1309775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G2an
    Summary
    Predicted to enable glucan 1,3-alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of glucosidase II complex. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to human GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 358.7), Adrenal (RPKM 330.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ganab in Genome Data Viewer
    Location:
    1q43
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215222918..215242808)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205793910..205813704)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225096558..225116384)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 11 open reading frame 98 Neighboring gene uncharacterized LOC102551607 Neighboring gene integrator complex subunit 5 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene retinal outer segment membrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease. Porath B, et al. Am J Hum Genet, 2016 Jun 2. PMID 27259053, Free PMC Article
    2. Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal Transformation. Tian W, et al. Circulation, 2019 Oct 22. PMID 31462075, Free PMC Article
    3. Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals. Caputo AT, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27462106, Free PMC Article
    4. Isolated polycystic liver disease genes define effectors of polycystin-1 function. Besse W, et al. J Clin Invest, 2017 May 1. PMID 28375157, Free PMC Article
    5. The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. Pelletier MF, et al. Glycobiology, 2000 Aug. PMID 10929008

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucan 1,3-alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucan 1,3-alpha-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glucosidase II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glucosidase II complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neutral alpha-glucosidase AB
    Names
    alpha glucosidase 2 alpha neutral subunit
    glucosidase, alpha
    glucosidase, alpha; neutral AB
    neutral AB
    NP_001385713.1
    NP_001385714.1
    XP_063142985.1
    XP_063142986.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398784.2 → NP_001385713.1  neutral alpha-glucosidase AB isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Conserved Domains (2) summary
      cd06603
      Location:406 → 873
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:264 → 406
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

    2. NM_001398785.2 → NP_001385714.1  neutral alpha-glucosidase AB isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Conserved Domains (2) summary
      cd06603
      Location:384 → 851
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:242 → 384
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215222918..215242808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286915.1 → XP_063142985.1  neutral alpha-glucosidase AB isoform X1

      Related
      ENSRNOP00000036123.3, ENSRNOT00000035650.4

    2. XM_063286916.1 → XP_063142986.1  neutral alpha-glucosidase AB isoform X2

      Related
      ENSRNOP00000087021.2, ENSRNOT00000105221.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106334.1: Suppressed sequence

      Description
      NM_001106334.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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