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    Tle5 TLE family member 5, transcriptional modulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29466, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tle5provided by RGD
    Official Full Name
    TLE family member 5, transcriptional modulatorprovided by RGD
    Primary source
    RGD:2731
    See related
    EnsemblRapid:ENSRNOG00000052025 AllianceGenome:RGD:2731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aes; Grg; Grg-5
    Summary
    Predicted to enable identical protein binding activity and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of macromolecule biosynthetic process; and positive regulation of anoikis. Predicted to act upstream of or within regulation of DNA-templated transcription; regulation of growth; and skeletal system development. Predicted to be located in nucleus. Orthologous to human TLE5 (TLE family member 5, transcriptional modulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 1695.4), Muscle (RPKM 1204.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tle5 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8794123..8801056, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8143357..8150295, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11012843..11018156, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene TLE family member 2, transcriptional corepressor Neighboring gene G protein subunit alpha 11 Neighboring gene G protein subunit alpha 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. Wang WF, et al. Dev Dyn, 2002 May. PMID 11984876
    2. A rat homolog of the Drosophila enhancer of split (groucho) locus lacking WD-40 repeats. Schmidt CJ, et al. J Biol Chem, 1993 Dec 5. PMID 8245004
    3. Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. Tetsuka T, et al. J Biol Chem, 2000 Feb 11. PMID 10660609
    4. TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells. Brunquell C, et al. Mol Cancer Res, 2012 Nov. PMID 22952044, Free PMC Article
    5. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. Arce L, et al. BMC Cancer, 2009 May 21. PMID 19460168, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124620

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TLE family member 5
    Names
    R-esp1
    amino enhancer of split
    amino-terminal enhancer of split
    groucho-related protein 5
    related to Drosophila groucho

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019220.1 → NP_062093.1  TLE family member 5

      See identical proteins and their annotated locations for NP_062093.1

      Status: PROVISIONAL

      Source sequence(s)
      L14462
      UniProtKB/Swiss-Prot
      P63003, Q3MIF3
      UniProtKB/TrEMBL
      A0A0G2JZT6
      Related
      ENSRNOP00000092723.2, ENSRNOT00000113477.2
      Conserved Domains (1) summary
      pfam03920
      Location:11 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8794123..8801056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078585.2 → XP_038934513.1  TLE family member 5 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZT6
      Related
      ENSRNOP00000079330.2, ENSRNOT00000098364.2
      Conserved Domains (1) summary
      pfam03920
      Location:11 → 131
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    2. XM_039078584.2 → XP_038934512.1  TLE family member 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ARX3
      Conserved Domains (1) summary
      pfam03920
      Location:50 → 170
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    3. XM_039078583.2 → XP_038934511.1  TLE family member 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARX3
      Related
      ENSRNOP00000097044.2, ENSRNOT00000100632.2
      Conserved Domains (1) summary
      pfam03920
      Location:50 → 171
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    4. XM_039078586.2 → XP_038934514.1  TLE family member 5 isoform X4

      Conserved Domains (1) summary
      pfam03920
      Location:50 → 117
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    5. XM_039078587.2 → XP_038934515.1  TLE family member 5 isoform X5

      Conserved Domains (1) summary
      pfam03920
      Location:50 → 84
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63003.1 GenPept UniProtKB/Swiss-Prot:P63003

    Gene LinkOut

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