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    GRIP2 glutamate receptor interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 80852, updated on 7-Apr-2024

    Summary

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    Official Symbol
    GRIP2provided by HGNC
    Official Full Name
    glutamate receptor interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:23841
    See related
    Ensembl:ENSG00000144596 AllianceGenome:HGNC:23841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein C-terminus binding activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of AMPA glutamate receptor clustering; and positive regulation of excitatory postsynaptic potential. Predicted to act upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Predicted to be located in cytoplasm; dendritic shaft; and neuron spine. Predicted to be active in glutamatergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart (RPKM 7.1), spleen (RPKM 5.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GRIP2 in Genome Data Viewer
    Location:
    3p25.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (14489107..14603017, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (14491513..14605422, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14530615..14581849, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14394065-14394622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14395183-14395740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14395741-14396298 Neighboring gene long intergenic non-protein coding RNA 1267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14408879-14409397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14417978-14418496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14418497-14419013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14424454-14424979 Neighboring gene uncharacterized LOC105376959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14435811-14436550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19507 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14447712-14447882 Neighboring gene RNA, 5S ribosomal pseudogene 124 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:14451820-14453019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14462886-14463709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14463710-14464532 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14469801-14469955 Neighboring gene solute carrier family 6 member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14473371-14474282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14476107-14477018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14477019-14477930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14480905-14481405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14492974-14493781 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14500879-14501379 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14502387-14502908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14501865-14502386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14502909-14503430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14513531-14514422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14537432-14537994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14539103-14539603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14546947-14547448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14547449-14547948 Neighboring gene Sharpr-MPRA regulatory region 227/3570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14555415-14555916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14559661-14560465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14562934-14563775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14563776-14564616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14566631-14567132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14567133-14567632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14573046-14573836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14573837-14574627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14577662-14578621 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14584584-14585084 Neighboring gene RNA, U6 small nuclear 905, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14589426-14589926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14605328-14605895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14615395-14615896 Neighboring gene RHBDF1 pseudogene 1 Neighboring gene uncharacterized LOC105376960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14661555-14662054 Neighboring gene uncharacterized LOC124909347 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14692810-14693468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19515 Neighboring gene uncharacterized LOC124906215 Neighboring gene coiled-coil domain containing 174

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. Lin SH, et al. Mol Pharmacol, 2001 Nov. PMID 11641419
    2. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Srivastava S, et al. Neuron, 1998 Sep. PMID 9768844
    3. The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. Stegmüller J, et al. J Biol Chem, 2003 Feb 7. PMID 12458226
    4. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. Ko J, et al. J Biol Chem, 2003 Oct 24. PMID 12923177
    5. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Lu W, et al. Neuron, 2005 Aug 4. PMID 16055064

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in artery smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080423.4 → NP_001073892.3  glutamate receptor-interacting protein 2

      See identical proteins and their annotated locations for NP_001073892.3

      Status: VALIDATED

      Source sequence(s)
      AB051506, AC090952, AK024507, AK095762
      Consensus CDS
      CCDS46766.2
      UniProtKB/Swiss-Prot
      A0A087WU38, Q8TEH9, Q9C0E4, Q9H7H3
      UniProtKB/TrEMBL
      A0A1B0GWJ3
      Related
      ENSP00000478352.1, ENST00000621039.5
      Conserved Domains (1) summary
      cd00992
      Location:655 → 735
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      14489107..14603017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449036.1 → XP_047304992.1  glutamate receptor-interacting protein 2 isoform X4

    2. XM_011534142.4 → XP_011532444.1  glutamate receptor-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GWJ3
      Conserved Domains (1) summary
      cd00992
      Location:660 → 740
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. XM_011534143.4 → XP_011532445.1  glutamate receptor-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GWJ3
      Conserved Domains (1) summary
      cd00992
      Location:620 → 700
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    4. XM_011534141.4 → XP_011532443.1  glutamate receptor-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWJ3
      Related
      ENSP00000490949.1, ENST00000637182.1
      Conserved Domains (1) summary
      cd00992
      Location:662 → 742
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    5. XM_011534146.4 → XP_011532448.1  glutamate receptor-interacting protein 2 isoform X7

      Conserved Domains (1) summary
      cd00992
      Location:408 → 488
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    6. XM_011534145.4 → XP_011532447.1  glutamate receptor-interacting protein 2 isoform X6

      Conserved Domains (1) summary
      cd00992
      Location:434 → 514
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    7. XM_047449037.1 → XP_047304993.1  glutamate receptor-interacting protein 2 isoform X5

    8. XM_047449038.1 → XP_047304994.1  glutamate receptor-interacting protein 2 isoform X8

    9. XM_047449040.1 → XP_047304996.1  glutamate receptor-interacting protein 2 isoform X9

    RNA

    1. XR_007095752.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      14491513..14605422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348046.1 → XP_054204021.1  glutamate receptor-interacting protein 2 isoform X4

    2. XM_054348044.1 → XP_054204019.1  glutamate receptor-interacting protein 2 isoform X2

    3. XM_054348043.1 → XP_054204018.1  glutamate receptor-interacting protein 2 isoform X1

    4. XM_054348045.1 → XP_054204020.1  glutamate receptor-interacting protein 2 isoform X3

    5. XM_054348049.1 → XP_054204024.1  glutamate receptor-interacting protein 2 isoform X7

    6. XM_054348048.1 → XP_054204023.1  glutamate receptor-interacting protein 2 isoform X6

    7. XM_054348047.1 → XP_054204022.1  glutamate receptor-interacting protein 2 isoform X5

    8. XM_054348050.1 → XP_054204025.1  glutamate receptor-interacting protein 2 isoform X8

    9. XM_054348051.1 → XP_054204026.1  glutamate receptor-interacting protein 2 isoform X9

    RNA

    1. XR_008486831.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C0E4.4 GenPept UniProtKB/Swiss-Prot:Q9C0E4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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