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    REM1 RRAD and GEM like GTPase 1 [ Homo sapiens (human) ]

    Gene ID: 28954, updated on 28-Oct-2024

    Summary

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    Official Symbol
    REM1provided by HGNC
    Official Full Name
    RRAD and GEM like GTPase 1provided by HGNC
    Primary source
    HGNC:HGNC:15922
    See related
    Ensembl:ENSG00000088320 MIM:610388; AllianceGenome:HGNC:15922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GES; GD:REM
    Summary
    The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 3.0), endometrium (RPKM 2.6) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See REM1 in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31475288..31484895)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33199537..33209122)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30063091..30072698)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene defensin beta 123 Neighboring gene defensin beta 124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12756 Neighboring gene long intergenic non-protein coding RNA 28 Neighboring gene tRNA-Ser (anticodon AGA) 7-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ges, A human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization. Pan JY, et al. J Cell Biol, 2000 May 29. PMID 10831614, Free PMC Article
    2. Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition. Correll RN, et al. J Biol Chem, 2007 Sep 28. PMID 17686775, Free PMC Article
    3. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Jhun BS, et al. Circ Res, 2012 Jan 6. PMID 22076634, Free PMC Article
    4. L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. Crump SM, et al. Am J Physiol Heart Circ Physiol, 2006 Oct. PMID 16648185
    5. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. Finlin BS, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14623965, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC48669

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of high voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of skeletal muscle contraction by calcium ion signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in I band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein REM 1
    Names
    GTPase-regulating endothelial cell sprouting
    RAS (RAD and GEM)-like GTP-binding 1
    NP_054731.2
    XP_005260461.1
    XP_011527097.1
    XP_016883322.1
    XP_054179372.1
    XP_054179373.1
    XP_054179374.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046939.1 RefSeqGene

      Range
      5001..14608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014012.6 → NP_054731.2  GTP-binding protein REM 1

      See identical proteins and their annotated locations for NP_054731.2

      Status: REVIEWED

      Source sequence(s)
      AF152863, AK313060
      Consensus CDS
      CCDS13181.1
      UniProtKB/Swiss-Prot
      E1P5L1, O75628, Q5TZR7, Q5TZR8, Q9NP57
      Related
      ENSP00000201979.2, ENST00000201979.3
      Conserved Domains (2) summary
      smart00010
      Location:81 → 237
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04148
      Location:81 → 298
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      31475288..31484895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260404.1 → XP_005260461.1  GTP-binding protein REM 1 isoform X1

      Conserved Domains (2) summary
      smart00010
      Location:81 → 245
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04148
      Location:81 → 306
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

    2. XM_011528795.1 → XP_011527097.1  GTP-binding protein REM 1 isoform X2

      Conserved Domains (2) summary
      smart00010
      Location:81 → 243
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04148
      Location:81 → 304
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

    3. XM_017027833.2 → XP_016883322.1  GTP-binding protein REM 1 isoform X1

      Conserved Domains (2) summary
      smart00010
      Location:81 → 245
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04148
      Location:81 → 306
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      33199537..33209122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323397.1 → XP_054179372.1  GTP-binding protein REM 1 isoform X1

    2. XM_054323399.1 → XP_054179374.1  GTP-binding protein REM 1 isoform X2

    3. XM_054323398.1 → XP_054179373.1  GTP-binding protein REM 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75628.2 GenPept UniProtKB/Swiss-Prot:O75628

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