ARPIN actin related protein 2/3 complex inhibitor [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARPINprovided by HGNC
Official Full Name: actin related protein 2/3 complex inhibitorprovided by HGNC
Primary source: HGNC:HGNC:28782
See related: Ensembl:ENSG00000242498 MIM:615543; AllianceGenome:HGNC:28782
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C15orf38
Summary: Involved in directional locomotion; negative regulation of cell migration; and negative regulation of cellular component organization. Predicted to be located in lamellipodium. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in colon (RPKM 5.0), ovary (RPKM 4.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q26.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (89895006..89912952, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (87651017..87668969, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (90438238..90456184, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN.
Title: RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN.
Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
Title: Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus.
Title: Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus.
ARPIN is down-regulated in breast cancer cells and predicts poor prognosis in breast cancer patients. Data suggest that restoration of ARPIN in breast cancer cells suppresses cell proliferation, colony formation, cell cycle distribution, invasion in vitro, and tumorigenesis in vivo (xenograft experiments in nude mice); Arpin acts as tumor suppressor in breast cancer and is associated with inhibition of Akt signaling.
Title: Restoration of Arpin suppresses aggressive phenotype of breast cancer cells.
Low Arpin levels are associated with clinicopathological variables and a poor prognosis in gastric cancer patients
Title: Clinicopathological and prognostic significance of aberrant Arpin expression in gastric cancer.
Data reveal that Arpin is comprised of an elongated globular core from which the C-terminal tail extends as a linear peptide, thus forming a primary epitope that is readily available to tether Arpin to interacting proteins.
Title: Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope.
Arpin downregulation may contribute to the initiation and development of breast cancer metastasis.
Title: Aberrant expression of Arpin in human breast cancer and its clinical significance.
Arpin protein affects the expression of tight junction proteins and may have an impact on bacterial translocation in severe acute pancreatitis.
Title: Arpin contributes to bacterial translocation and development of severe acute pancreatitis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Web-based, participant-driven studies yield novel genetic associations for common traits. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Readthrough ARPIN-AP3S2

Readthrough gene: ARPIN-AP3S2, Included gene: AP3S2

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in directional locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: arpin

Names: UPF0552 protein C15orf38; arp2/3 inhibition protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282380.2 → NP_001269309.1 arpin isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC027176, AK055252, AK093274, BC053602, BM023230

Consensus CDS

CCDS73780.1

UniProtKB/TrEMBL

H0YL03, H0YMP5

Related

ENSP00000453687.1, ENST00000460685.1

Conserved Domains (1) summary

pfam10574
Location:1 → 128

UPF0552; uncharacterized protein family UPF0552
NM_182616.4 → NP_872422.1 arpin isoform 1

See identical proteins and their annotated locations for NP_872422.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AC027176, AK055252, BC053602, BM023230, DB285255

Consensus CDS

CCDS42080.1

UniProtKB/Swiss-Prot

E2QRD5, Q7Z6K5

Related

ENSP00000350075.5, ENST00000357484.10

Conserved Domains (1) summary

pfam10574
Location:1 → 224

UPF0552; uncharacterized protein family UPF0552