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    OXCT2 3-oxoacid CoA-transferase 2 [ Homo sapiens (human) ]

    Gene ID: 64064, updated on 28-Oct-2024

    Summary

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    Official Symbol
    OXCT2provided by HGNC
    Official Full Name
    3-oxoacid CoA-transferase 2provided by HGNC
    Primary source
    HGNC:HGNC:18606
    See related
    Ensembl:ENSG00000198754 MIM:610289; AllianceGenome:HGNC:18606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCOTT; FKSG25
    Summary
    The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]
    Orthologs
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    Genomic context

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    See OXCT2 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (39769523..39771348, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (39638968..39640793, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40235195..40237020, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 121 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 816 Neighboring gene peptidylprolyl isomerase E Neighboring gene bone morphogenetic protein 8b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40236393-40237066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40237067-40237739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 817 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40244416-40244916 Neighboring gene BMP8B antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40254643-40255144 Neighboring gene uncharacterized LOC101929536

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dimeric pig heart succinate-coenzyme A transferase uses only one subunit to support catalysis. Lloyd AJ, et al. Biochemistry, 2001 Feb 27. PMID 11327867
    2. Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA. Tanaka H, et al. Mol Hum Reprod, 2002 Jan. PMID 11756565
    3. Characterization of long cDNA clones from human adult spleen. Hattori A, et al. DNA Res, 2000 Dec 31. PMID 11214971
    4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article
    5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Floyd BJ, et al. Mol Cell, 2016 Aug 18. PMID 27499296, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00030

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables succinyl-CoA:3-oxo-acid CoA-transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular ketone body metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ketone body catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
    Names
    3-oxoacid CoA-transferase 2A
    testis-specific succinyl CoA:3-oxoacid CoA-transferase
    NP_071403.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022120.2 → NP_071403.1  succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_071403.1

      Status: REVIEWED

      Source sequence(s)
      AL033527, AY013700
      Consensus CDS
      CCDS445.1
      UniProtKB/Swiss-Prot
      B2RBB4, Q5QPK4, Q8NHR1, Q9BYC2, Q9H1I4
      UniProtKB/TrEMBL
      B3KS89
      Related
      ENSP00000361914.1, ENST00000327582.5
      Conserved Domains (3) summary
      COG1788
      Location:48 → 274
      AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
      COG4670
      Location:48 → 514
      YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]
      cl00339
      Location:297 → 505
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      39769523..39771348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      39638968..39640793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BYC2.2 GenPept UniProtKB/Swiss-Prot:Q9BYC2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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