FUT7 fucosyltransferase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FUT7provided by HGNC
Official Full Name: fucosyltransferase 7provided by HGNC
Primary source: HGNC:HGNC:4018
See related: Ensembl:ENSG00000180549 MIM:602030; AllianceGenome:HGNC:4018
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FucT-VII
Summary: The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lymph node (RPKM 1.7), spleen (RPKM 1.5) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q34.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (137030174..137032088, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (149264609..149266523, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (139924626..139926540, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of FUT7 hypomethylation as the blood biomarker in the prediction of early-stage lung cancer.
Title: Identification of FUT7 hypomethylation as the blood biomarker in the prediction of early-stage lung cancer.
Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma.
Title: Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma.
Activation of alpha7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition.
Title: Activation of α7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition.
Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.
Title: Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.
High FUT7 expression and CD15 are associated with lung and brain metastasis.
Title: Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.
the findings in this study suggest that hypomethylated CpG sites, present in four regions of the FOXP3 locus, CAMTA1 and FUT7 gene regions, can potentially be used to distinguish subsets of CD4+ T lymphocytes in both sexes.
Title: Molecular Markers Distinguishing T Cell Subtypes With TSDR Strand-Bias Methylation.
Knockdown of FUT7 inhibits human hepatocarcinoma cell proliferation.
Title: α-1,3-Fucosyltransferase-VII siRNA inhibits the expression of SLex and hepatocarcinoma cell proliferation.
FUT7 silencing causes inhibition of adhesion and migration of HepG2 hepatocellular carcinoma cells in vitro.
Title: Inhibition of adhesion and metastasis of HepG2 hepatocellular carcinoma cells in vitro by DNA aptamer against sialyl Lewis X.
FUT7 overexpression significantly promoted monocyte-endothelial adhesion, while FUT7 knockdown obviously inhibited IL-1beta-induced monocyte-endothelial adhesion
Title: The α1,3-fucosyltransferase FUT7 regulates IL-1β-induced monocyte-endothelial adhesion via fucosylation of endomucin.
The DNA demethylation within the fut7 gene controls selectin ligand expression in humans, including the inducible topographic commitment of T cells for skin and inflamed sites.
Title: Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-X78031 (e-PCR)
- UniSTS:55552

FUT7_665 (e-PCR)
- UniSTS:277259

PMC16366P1 (e-PCR)
- UniSTS:271476

NoName (e-PCR)
- UniSTS:481955

NoName (e-PCR)
- UniSTS:486577

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->3)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in L-fucose catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell migration	IEA Inferred from Electronic Annotation more info
involved_in ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte migration involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymphocyte migration into lymph node	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligosaccharide biosynthetic process	TAS Traceable Author Statement more info
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell adhesion molecule production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neutrophil extravasation	IEA Inferred from Electronic Annotation more info
involved_in regulation of type IV hypersensitivity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-(1,3)-fucosyltransferase 7

Names: fuc-TVII; fucosyltransferase 7 (alpha (1,3) fucosyltransferase); fucosyltransferase VII; galactoside 3-L-fucosyltransferase; selectin-ligand synthase

NP_004470.1

EC 2.4.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007527.1 RefSeqGene

Range

5753..7667

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004479.4 → NP_004470.1 alpha-(1,3)-fucosyltransferase 7

See identical proteins and their annotated locations for NP_004470.1

Status: REVIEWED

Source sequence(s)

AL807752

Consensus CDS

CCDS7022.1

UniProtKB/Swiss-Prot

B2R7U7, Q11130, Q6DK54

Related

ENSP00000318142.6, ENST00000314412.7

Conserved Domains (2) summary

pfam00852
Location:169 → 337

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:44 → 154

Glyco_tran_10_N; Fucosyltransferase, N-terminal