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    STAU2 staufen double-stranded RNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 27067, updated on 28-Oct-2024

    Summary

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    Official Symbol
    STAU2provided by HGNC
    Official Full Name
    staufen double-stranded RNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:11371
    See related
    Ensembl:ENSG00000040341 MIM:605920; AllianceGenome:HGNC:11371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    39K2; 39K3
    Summary
    Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
    Expression
    Ubiquitous expression in brain (RPKM 12.9), heart (RPKM 8.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STAU2 in Genome Data Viewer
    Location:
    8q21.11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (73420369..73747480, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (73850269..74176939, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74332604..74659715, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RDH10 antisense RNA 1 Neighboring gene retinol dehydrogenase 10 Neighboring gene uncharacterized LOC105375899 Neighboring gene STAU2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27532 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:74500454-74500955 Neighboring gene Sharpr-MPRA regulatory region 7553 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:74583372-74583561 Neighboring gene MPRA-validated peak7072 silencer Neighboring gene VENT homeobox pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19289 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19288 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19292 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:74743717-74743929 Neighboring gene ubiquitin conjugating enzyme E2 W Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:74756087-74756814 Neighboring gene RNA, 7SL, cytoplasmic 760, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74785489-74785988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:74790306-74791183 Neighboring gene long intergenic non-protein coding RNA 1617

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Encapsidation of Staufen-2 Enhances Infectivity of HIV-1. Balakrishnan K, et al. Viruses, 2021 Dec 8. PMID 34960728, Free PMC Article
    2. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Park E, et al. Proc Natl Acad Sci U S A, 2013 Jan 8. PMID 23263869, Free PMC Article
    3. The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. Zhang X, et al. Nucleic Acids Res, 2016 May 5. PMID 26843428, Free PMC Article
    4. Quantitative STAU2 measurement in lymphocytes for breast cancer risk assessment. Puttipanyalears C, et al. Sci Rep, 2021 Jan 13. PMID 33441653, Free PMC Article
    5. STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells. Condé L, et al. BMC Mol Cell Biol, 2021 Mar 4. PMID 33663378, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF216 affects the stability of STAU2 in the hypothalamus.
      Title: RNF216 affects the stability of STAU2 in the hypothalamus.
    2. Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
      Title: Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
    3. Encapsidation of Staufen-2 Enhances Infectivity of HIV-1.
      Title: Encapsidation of Staufen-2 Enhances Infectivity of HIV-1.
    4. STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells.
      Title: STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells.
    5. Quantitative STAU2 measurement in lymphocytes for breast cancer risk assessment.
      Title: Quantitative STAU2 measurement in lymphocytes for breast cancer risk assessment.
    6. during genotoxic stress, Stau2 is downregulated at the promoter level in an ATR- and E2F1-dependent manner, leading to increased levels of DNA damage and apoptosis.
      Title: The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.
    7. Authors establish that human Staufen-2, a host factor which is up-regulated upon HIV-1 infection, interacts with HIV-1 Rev, thereby promoting its RNA export activity and progeny virus formation.
      Title: Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev.
    8. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.
      Title: Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.
    9. We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression
      Title: Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.
    10. Stau1- and Stau2-mRNPs associate with distinct but overlapping sets of cellular mRNAs.
      Title: A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with staufen is mediated by staufen's dsRBD3 domain PubMed
    gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
    Rev rev HIV-1 Rev interacts with human STAU-2 protein in a RNA-independent manner and influences the sub-cellular localization of STAU-2. HIV-1 infection upregulates STAU-2 expression in human T-lymphocytes and astrocytes PubMed
    capsid gag Human STAU-2 increases HIV-1 production with upregulated levels of HIV-1 CA PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119606, DKFZp781K0371

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinesin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular mRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of long-term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    double-stranded RNA-binding protein Staufen homolog 2
    Names
    staufen homolog 2
    staufen, RNA binding protein, homolog 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164380.2 → NP_001157852.1  double-stranded RNA-binding protein Staufen homolog 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest isoform (a).
      Source sequence(s)
      AC100784, AF459097, AK002152
      Consensus CDS
      CCDS55247.1
      UniProtKB/Swiss-Prot
      A0A0A0MTC5, B7Z1I6, B7Z292, B7Z8B4, E7ER74, E9PEI3, E9PF26, E9PF50, Q6AHY7, Q96HM0, Q96HM1, Q9NUL3, Q9NVI5, Q9UGG6
      UniProtKB/TrEMBL
      E7EVJ4
      Related
      ENSP00000428756.1, ENST00000524300.6
      Conserved Domains (2) summary
      smart00358
      Location:308 → 374
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:459 → 523
      Staufen_C; Staufen C-terminal domain

    2. NM_001164381.2 → NP_001157853.1  double-stranded RNA-binding protein Staufen homolog 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC100784, AF459097, BC008369
      Consensus CDS
      CCDS55248.1
      UniProtKB/TrEMBL
      A8K276
      Related
      ENSP00000428456.1, ENST00000522695.5
      Conserved Domains (2) summary
      smart00358
      Location:276 → 342
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:427 → 491
      Staufen_C; Staufen C-terminal domain

    3. NM_001164382.2 → NP_001157854.1  double-stranded RNA-binding protein Staufen homolog 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC100784, AF459097, AK002152, AK303104
      Consensus CDS
      CCDS55245.1
      UniProtKB/TrEMBL
      A8K276
      Related
      ENSP00000429173.1, ENST00000521210.5
      Conserved Domains (3) summary
      smart00358
      Location:204 → 270
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:37 → 75
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:355 → 457
      Staufen_C; Staufen C-terminal domain

    4. NM_001164383.2 → NP_001157855.1  double-stranded RNA-binding protein Staufen homolog 2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC100784, AF459097, AK002152, AK293496
      Consensus CDS
      CCDS55244.1
      UniProtKB/TrEMBL
      E5RJN7
      Related
      ENSP00000428741.1, ENST00000523558.5
      Conserved Domains (2) summary
      smart00358
      Location:136 → 202
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:287 → 351
      Staufen_C; Staufen C-terminal domain

    5. NM_001164384.2 → NP_001157856.1  double-stranded RNA-binding protein Staufen homolog 2 isoform e

      See identical proteins and their annotated locations for NP_001157856.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (e) has shorter and distinct N- and C-termini compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
      Source sequence(s)
      AB210014, AK001576, AK023314, AK290141, CA311807, Y19062
      Consensus CDS
      CCDS6214.1
      UniProtKB/TrEMBL
      A8K276
      Related
      ENSP00000427977.1, ENST00000522509.5
      Conserved Domains (5) summary
      pfam16482
      Location:427 → 479
      Staufen_C; Staufen C-terminal domain
      cd19882
      Location:66 → 147
      DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
      cd19884
      Location:174 → 240
      DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
      cd19886
      Location:272 → 357
      DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
      cl00054
      Location:6 → 38
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    6. NM_001164385.2 → NP_001157857.1  double-stranded RNA-binding protein Staufen homolog 2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AB210014, AK001576, AK023314, AK294466, CA311807
      Consensus CDS
      CCDS55246.1
      UniProtKB/TrEMBL
      A8K276
      Related
      ENSP00000431111.1, ENST00000517542.5
      Conserved Domains (2) summary
      smart00358
      Location:270 → 336
      DSRM; Double-stranded RNA binding motif
      pfam16482
      Location:421 → 473
      Staufen_C; Staufen C-terminal domain

    7. NM_014393.3 → NP_055208.2  double-stranded RNA-binding protein Staufen homolog 2 isoform e

      See identical proteins and their annotated locations for NP_055208.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (e) has shorter and distinct N- and C-termini compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
      Source sequence(s)
      AB210014, AK001576, AK023314, CA311807, DB501161, Y19062
      Consensus CDS
      CCDS6214.1
      UniProtKB/TrEMBL
      A8K276
      Related
      ENSP00000348026.5, ENST00000355780.9
      Conserved Domains (5) summary
      pfam16482
      Location:427 → 479
      Staufen_C; Staufen C-terminal domain
      cd19882
      Location:66 → 147
      DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
      cd19884
      Location:174 → 240
      DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
      cd19886
      Location:272 → 357
      DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
      cl00054
      Location:6 → 38
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      73420369..73747480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      73850269..74176939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NUL3.2 GenPept UniProtKB/Swiss-Prot:Q9NUL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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