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    CGB3 chorionic gonadotropin subunit beta 3 [ Homo sapiens (human) ]

    Gene ID: 1082, updated on 2-Nov-2024

    Summary

    Official Symbol
    CGB3provided by HGNC
    Official Full Name
    chorionic gonadotropin subunit beta 3provided by HGNC
    Primary source
    HGNC:HGNC:1886
    See related
    Ensembl:ENSG00000104827 MIM:118860; AllianceGenome:HGNC:1886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGB; LHB; CGB5; CGB7; CGB8; hCGB
    Summary
    This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward placenta (RPKM 30.5) See more
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    Genomic context

    See CGB3 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49022869..49024333, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52017651..52019115, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49526126..49527590, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RuvB like AAA ATPase 2 Neighboring gene Sharpr-MPRA regulatory region 164 Neighboring gene uncharacterized LOC124904738 Neighboring gene luteinizing hormone subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14924 Neighboring gene stabilizer of axonemal microtubules 3 Neighboring gene neurotrophin 6 alpha (pseudogene) Neighboring gene neurotrophin 6 gamma (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in female gamete generation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of pituitary gonadotropin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    choriogonadotropin subunit beta 3
    Names
    CG-beta
    chorionic gonadotrophin chain beta
    chorionic gonadotropin beta 3 subunit
    chorionic gonadotropin beta chain
    chorionic gonadotropin beta subunit 3
    chorionic gonadotropin chain beta
    chorionic gonadotropin, beta polypeptide
    luteinizing hormone beta subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000737.5NP_000728.1  choriogonadotropin subunit beta 3 precursor

      See identical proteins and their annotated locations for NP_000728.1

      Status: REVIEWED

      Source sequence(s)
      AK291552, BC106059
      Consensus CDS
      CCDS12749.1
      UniProtKB/Swiss-Prot
      A1A5E0, B9ZVP5, P01233, P0DN86, Q13991, Q14000, Q3KPI3, Q3SY41, Q8WTT5, Q8WXL1, Q8WXL2, Q8WXL3, Q8WXL4
      UniProtKB/TrEMBL
      A0A0F7RPU2, A0A0F7RQP8
      Related
      ENSP00000349954.2, ENST00000357383.4
      Conserved Domains (1) summary
      smart00068
      Location:25131
      GHB; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49022869..49024333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52017651..52019115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)