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    C1orf74 chromosome 1 open reading frame 74 [ Homo sapiens (human) ]

    Gene ID: 148304, updated on 17-Sep-2024

    Summary

    Official Symbol
    C1orf74provided by HGNC
    Official Full Name
    chromosome 1 open reading frame 74provided by HGNC
    Primary source
    HGNC:HGNC:26319
    See related
    Ensembl:ENSG00000162757 AllianceGenome:HGNC:26319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    URLC4
    Expression
    Broad expression in lymph node (RPKM 8.4), spleen (RPKM 5.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See C1orf74 in Genome Data Viewer
    Location:
    1q32.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (209779208..209784559, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (209025976..209031327, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (209952553..209957904, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene HSD11B1 antisense RNA 1 Neighboring gene hydroxysteroid 11-beta dehydrogenase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2471 Neighboring gene adenosine A2b receptor pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2473 Neighboring gene TRAF3 interacting protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:209944889-209945388 Neighboring gene MPRA-validated peak675 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:209957609-209958226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:209958227-209958842 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:209979409-209979752 Neighboring gene interferon regulatory factor 6 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_2681 Neighboring gene VISTA enhancer hs932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2477 Neighboring gene Sharpr-MPRA regulatory region 1786 Neighboring gene UTP25 small subunit processome component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    UPF0739 protein C1orf74
    Names
    up-regulated in lung cancer 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152485.4NP_689698.1  UPF0739 protein C1orf74

      See identical proteins and their annotated locations for NP_689698.1

      Status: VALIDATED

      Source sequence(s)
      AB101206, AI922337, AK022798, AL022398
      Consensus CDS
      CCDS1491.1
      UniProtKB/Swiss-Prot
      Q96LT6
      UniProtKB/TrEMBL
      A0A0A8K8E6
      Related
      ENSP00000294811.1, ENST00000294811.2
      Conserved Domains (1) summary
      pfam14953
      Location:21268
      DUF4504; Domain of unknown function (DUF4504)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      209779208..209784559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      209025976..209031327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)