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    ATG13 autophagy related 13 [ Homo sapiens (human) ]

    Gene ID: 9776, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ATG13provided by HGNC
    Official Full Name
    autophagy related 13provided by HGNC
    Primary source
    HGNC:HGNC:29091
    See related
    Ensembl:ENSG00000175224 MIM:615088; AllianceGenome:HGNC:29091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA0652; PARATARG8
    Summary
    The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in testis (RPKM 17.3), brain (RPKM 12.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATG13 in Genome Data Viewer
    Location:
    11p11.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (46617553..46674518)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (46773592..46830534)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46639103..46696068)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene ribosomal protein S10 pseudogene 19 Neighboring gene NANOG hESC enhancer GRCh37_chr11:46467611-46468112 Neighboring gene microRNA 3160-1 Neighboring gene microRNA 3160-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3313 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:46559175-46559678 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46559679-46560184 Neighboring gene Sharpr-MPRA regulatory region 9650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:46587793-46588293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4681 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:46605824-46606668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:46615325-46615825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4683 Neighboring gene Sharpr-MPRA regulatory region 32 Neighboring gene harbinger transposase derived 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:46715957-46716456 Neighboring gene Rho GTPase activating protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4684 Neighboring gene zinc finger protein 408

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ATG13 dynamics in nonselective autophagy and mitophagy: insights from live imaging studies and mathematical modeling. Dalle Pezze P, et al. Autophagy, 2021 May. PMID 32320309, Free PMC Article
    2. ATG13 restricts viral replication by induction of type I interferon. Du JL, et al. J Cell Mol Med, 2019 Sep. PMID 31270922, Free PMC Article
    3. Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE). Gottschalk G, et al. Mol Cell Neurosci, 2022 May. PMID 35487443
    4. The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis. Nguyen A, et al. FEBS Lett, 2024 Jan. PMID 37567770
    5. The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells. Woo M, et al. Biochem Biophys Res Commun, 2020 Apr 9. PMID 32035621

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metamorphosis by ATG13 and ATG101 in human autophagy initiation.
      Title: Metamorphosis by ATG13 and ATG101 in human autophagy initiation.
    2. The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.
      Title: The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.
    3. The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.
      Title: The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.
    4. Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE).
      Title: Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE).
    5. Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.
      Title: Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.
    6. LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
      Title: LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
    7. ATG13 dynamics in nonselective autophagy and mitophagy: insights from live imaging studies and mathematical modeling.
      Title: ATG13 dynamics in nonselective autophagy and mitophagy: insights from live imaging studies and mathematical modeling.
    8. The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death.
      Title: The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death.
    9. CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a.
      Title: CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a.
    10. Klotho-mediated changes in the expression of Atg13 alter formation of ULK1 complex and thus initiation of ER- and Golgi-stress response mediated autophagy.
      Title: Klotho-mediated changes in the expression of Atg13 alter formation of ULK1 complex and thus initiation of ER- and Golgi-stress response mediated autophagy.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20698, KIAA0652

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein lipidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to mitochondrial depolarisation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Atg1/ULK1 kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    autophagy-related protein 13
    Names
    ATG13 autophagy related 13 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051811.2 RefSeqGene

      Range
      5002..61967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142673.3 → NP_001136145.1  autophagy-related protein 13 isoform c

      See identical proteins and their annotated locations for NP_001136145.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) includes an alternate exon in the 5' UTR and lacks an exon in the coding region compared to variant 3. The resulting isoform (c, also known as isoform 1) is shorter but has the same N- and C- termini compared to isoform a. Variants 1, 4 and 15-28 all encode the same isoform (c).
      Source sequence(s)
      AK289641, BC002378, CD675643, DA195671
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6
      Conserved Domains (1) summary
      pfam10033
      Location:19 → 195
      ATG13; Autophagy-related protein 13

    2. NM_001205119.2 → NP_001192048.1  autophagy-related protein 13 isoform a

      See identical proteins and their annotated locations for NP_001192048.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (a, also known as isoform 3). Variants 3 and 7-12 all encode the same isoform (a).
      Source sequence(s)
      AK223603, BC002378, DA195671
      Consensus CDS
      CCDS55760.1
      UniProtKB/TrEMBL
      A8K0S6
      Related
      ENSP00000432412.1, ENST00000528494.5
      Conserved Domains (1) summary
      pfam10033
      Location:19 → 195
      ATG13; Autophagy-related protein 13

    3. NM_001205120.2 → NP_001192049.1  autophagy-related protein 13 isoform c

      See identical proteins and their annotated locations for NP_001192049.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon in the coding region compared to variant 3. The resulting isoform (c, also known as isoform 1) is shorter but has the same N- and C-termini compared to isoform a. Variants 1, 4, and 15-28 all encode the same isoform (c).
      Source sequence(s)
      AB014552, AC115088, DA195671
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6
      Related
      ENSP00000352500.4, ENST00000359513.8
      Conserved Domains (1) summary
      pfam10033
      Location:19 → 195
      ATG13; Autophagy-related protein 13

    4. NM_001205121.2 → NP_001192050.1  autophagy-related protein 13 isoform f

      See identical proteins and their annotated locations for NP_001192050.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes an alternate exon in the 5' UTR and lacks two exons in the coding region compared to variant 3. The resulting isoform (f, also known as isoform 2) is shorter but has the same N- and C- termini compared to isoform a. Variants 2, 5, and 36-45 all encode the same isoform (f).
      Source sequence(s)
      AB014552, AC115088, AK023867
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4
      Related
      ENSP00000433756.1, ENST00000529655.5
      Conserved Domains (1) summary
      pfam10033
      Location:19 → 195
      ATG13; Autophagy-related protein 13

    5. NM_001205122.2 → NP_001192051.1  autophagy-related protein 13 isoform h

      See identical proteins and their annotated locations for NP_001192051.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences compared to variant 3. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 3. The encoded isoform (h, also known as isoform 4) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AB014552, AC115088, AK294110, DA195671
      Consensus CDS
      CCDS55761.1
      UniProtKB/TrEMBL
      A8KAP4
      Related
      ENSP00000434390.1, ENST00000530500.5

    6. NM_001346311.2 → NP_001333240.1  autophagy-related protein 13 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 3 and 8-12, encodes isoform a.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS55760.1
      UniProtKB/TrEMBL
      A8K0S6
      Related
      ENSP00000507809.1, ENST00000683050.1

    7. NM_001346312.2 → NP_001333241.1  autophagy-related protein 13 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 3, 7, and 9-12, encodes isoform a
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS55760.1
      UniProtKB/TrEMBL
      A8K0S6

    8. NM_001346313.2 → NP_001333242.1  autophagy-related protein 13 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 3, 7-8, and 10-12, encodes isoform a.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS55760.1
      UniProtKB/TrEMBL
      A8K0S6

    9. NM_001346314.2 → NP_001333243.1  autophagy-related protein 13 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 3, 7-9, and 11-12, encodes isoform a.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS55760.1
      UniProtKB/TrEMBL
      A8K0S6

    10. NM_001346315.2 → NP_001333244.1  autophagy-related protein 13 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 3, 7-10, and 12, encodes isoform a.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS55760.1
      UniProtKB/TrEMBL
      A8K0S6

    11. NM_001346316.2 → NP_001333245.1  autophagy-related protein 13 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 3 and 7-11, encodes isoform a.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS55760.1
      UniProtKB/TrEMBL
      A8K0S6

    12. NM_001346317.2 → NP_001333246.1  autophagy-related protein 13 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 14, encodes isoform b.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    13. NM_001346318.2 → NP_001333247.1  autophagy-related protein 13 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variant 13, encodes isoform b.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    14. NM_001346319.2 → NP_001333248.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 1, 4, and 16-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    15. NM_001346320.2 → NP_001333249.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 1, 4, 15, and 17-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    16. NM_001346321.2 → NP_001333250.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 1, 4, 15-16, and 18-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    17. NM_001346322.2 → NP_001333251.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 1, 4, 15-17, and 19-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    18. NM_001346323.2 → NP_001333252.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 1, 4, 15-18, and 20-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    19. NM_001346324.2 → NP_001333253.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 1, 4, 15-19, and 21-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6
      Related
      ENSP00000431974.1, ENST00000526508.5

    20. NM_001346325.2 → NP_001333254.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 1, 4, 15-20, and 22-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    21. NM_001346326.2 → NP_001333255.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 1, 4, 15-21, and 23-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    22. NM_001346327.2 → NP_001333256.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 1, 4, 15-22, and 24-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    23. NM_001346328.2 → NP_001333257.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 1, 4, 15-23, and 25-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    24. NM_001346329.2 → NP_001333258.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 1, 4, 15-24, and 26-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    25. NM_001346330.2 → NP_001333259.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 1, 4, 15-25, and 27-28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    26. NM_001346331.2 → NP_001333260.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 1, 4, 15-26, and 28, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    27. NM_001346332.2 → NP_001333261.1  autophagy-related protein 13 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variants 1, 4, and 15-27, encodes isoform c.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS44582.1
      UniProtKB/Swiss-Prot
      B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, O75143, Q53EN6, Q9BRL3, Q9H8B0
      UniProtKB/TrEMBL
      A8K0S6

    28. NM_001346333.2 → NP_001333262.1  autophagy-related protein 13 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 30-33, encodes isoform d.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    29. NM_001346334.2 → NP_001333263.1  autophagy-related protein 13 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 29 and 31-33, encodes isoform d.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    30. NM_001346335.2 → NP_001333264.1  autophagy-related protein 13 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 29-30 and 32-33, encodes isoform d.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    31. NM_001346336.2 → NP_001333265.1  autophagy-related protein 13 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 29-31 and 33, encodes isoform d.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    32. NM_001346337.2 → NP_001333266.1  autophagy-related protein 13 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 29-32, encodes isoform d.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    33. NM_001346338.2 → NP_001333267.1  autophagy-related protein 13 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variant 35, encodes isoform e.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    34. NM_001346340.2 → NP_001333269.1  autophagy-related protein 13 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (35), as well as variant 34, encodes isoform e.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8K0S6

    35. NM_001346342.2 → NP_001333271.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (36), as well as variants 2, 5, and 37-45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    36. NM_001346344.2 → NP_001333273.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (37), as well as variants 2, 5, 36, and 38-45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    37. NM_001346346.2 → NP_001333275.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (38), as well as variants 2, 5, 36-37, and 39-45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    38. NM_001346348.2 → NP_001333277.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (39), as well as variants 2, 5, 36-38, and 40-45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    39. NM_001346349.2 → NP_001333278.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (40), as well as variants 2, 5, 36-39, and 41-45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    40. NM_001346350.2 → NP_001333279.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (41), as well as variants 2, 5, 36-40, and 42-45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    41. NM_001346351.2 → NP_001333280.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (42), as well as variants 2, 5, 36-41, and 43-45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    42. NM_001346352.2 → NP_001333281.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (43), as well as variants 2, 5, 36-42, and 44-45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    43. NM_001346353.2 → NP_001333282.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (44), as well as variants 2, 5, 36-43, and 45, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    44. NM_001346354.2 → NP_001333283.1  autophagy-related protein 13 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (45), as well as variants 2, 5, and 36-44, encodes isoform f.
      Source sequence(s)
      AC115088, AC127035
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4

    45. NM_001346355.2 → NP_001333284.1  autophagy-related protein 13 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (46), as well as variant 47, encodes isoform g.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8KAP4

    46. NM_001346356.2 → NP_001333285.1  autophagy-related protein 13 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (47), as well as variant 46, encodes isoform g.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      A8KAP4

    47. NM_001346357.2 → NP_001333286.1  autophagy-related protein 13 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (48), as well as variants 49 and 50, encodes isoform i.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      B4DKE5

    48. NM_001346358.2 → NP_001333287.1  autophagy-related protein 13 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (49), as well as variants 48 and 50, encodes isoform i.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      B4DKE5

    49. NM_001346359.2 → NP_001333288.1  autophagy-related protein 13 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (50), as well as variants 48 and 49, encodes isoform i.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      B4DKE5

    50. NM_001346360.2 → NP_001333289.1  autophagy-related protein 13 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (51) encodes isoform j.
      Source sequence(s)
      AC115088, AC127035
      UniProtKB/TrEMBL
      B4DKE5

    51. NM_014741.5 → NP_055556.2  autophagy-related protein 13 isoform f

      See identical proteins and their annotated locations for NP_055556.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR and lacks two exons in the coding region compared to variant 3. The resulting isoform (f, also known as isoform 2) is shorter but has the same N- and C- termini compared to isoform a. Variants 2, 5, and 36-45 all encode the same isoform (f).
      Source sequence(s)
      BC002378, DA195671
      Consensus CDS
      CCDS7921.1
      UniProtKB/TrEMBL
      A8KAP4
      Related
      ENSP00000433543.1, ENST00000524625.5
      Conserved Domains (1) summary
      pfam10033
      Location:19 → 195
      ATG13; Autophagy-related protein 13

    RNA

    1. NR_144422.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115088, AC127035

    2. NR_144423.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115088, AC127035

    3. NR_144424.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC115088, AC127035

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      46617553..46674518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      46773592..46830534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75143.1 GenPept UniProtKB/Swiss-Prot:O75143

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials
    Tools
    Miscellaneous