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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008847.2 RefSeqGene
- Range
-
13732..58896
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_1074
mRNA and Protein(s)
-
NM_000162.5 → NP_000153.1 hexokinase-4 isoform 1
See identical proteins and their annotated locations for NP_000153.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the isoform expressed specifically in pancreatic islet beta cells. Its first exon is specific to this variant, which has a unique 5' UTR. Isoform 1 has a distinct N-terminus; the remainder of the protein is identical to isoforms 2 and 3.
- Source sequence(s)
-
AC006454, BC001890
- Consensus CDS
-
CCDS5479.1
- UniProtKB/Swiss-Prot
- A4D2J2, A4D2J3, P35557, Q05810
- UniProtKB/TrEMBL
- A7LFL1, Q53Y25
- Related
- ENSP00000384247.3, ENST00000403799.8
- Conserved Domains (2) summary
-
- COG5026
Location:8 → 458
- COG5026; Hexokinase [Carbohydrate transport and metabolism]
- pfam00349
Location:15 → 215
- Hexokinase_1
-
NM_001354800.1 → NP_001341729.1 hexokinase-4 isoform 4
Status: REVIEWED
- Source sequence(s)
-
AC006454
- Consensus CDS
-
CCDS94092.1
- UniProtKB/TrEMBL
- A0A5F9ZGW4, A7LFL1
- Related
- ENSP00000499852.1, ENST00000673284.1
- Conserved Domains (2) summary
-
- COG5026
Location:8 → 456
- COG5026; Hexokinase [Carbohydrate transport and metabolism]
- pfam00349
Location:15 → 215
- Hexokinase_1
-
NM_001354801.1 → NP_001341730.1 hexokinase-4 isoform 7
Status: REVIEWED
- Source sequence(s)
-
AC006454, M90299
- Related
-
ENST00000683378.1
- Conserved Domains (1) summary
-
- pfam03727
Location:2 → 118
- Hexokinase_2
-
NM_001354802.1 → NP_001341731.1 hexokinase-4 isoform 5
Status: REVIEWED
- Source sequence(s)
-
AC006454
- Conserved Domains (1) summary
-
- pfam03727
Location:1 → 75
- Hexokinase_2
-
NM_001354803.2 → NP_001341732.1 hexokinase-4 isoform 6
Status: REVIEWED
- Source sequence(s)
-
AC006454, M90299
- Consensus CDS
-
CCDS94091.1
- UniProtKB/TrEMBL
-
H7BXV0
- Related
- ENSP00000338009.5, ENST00000336642.9
- Conserved Domains (1) summary
-
- pfam03727
Location:19 → 133
- Hexokinase_2
-
NM_033507.3 → NP_277042.1 hexokinase-4 isoform 2
See identical proteins and their annotated locations for NP_277042.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) encodes the major isoform expressed in liver. Its first exon is specific to the liver transcripts, variants 2 and 3, but it lacks a second liver-specific exon found in variant 3. Isoform 2 has a distinct N-terminus; the remainder of the protein is identical to isoforms 1 and 3.
- Source sequence(s)
-
AK122876, CD251038, M69051, M90299
- Consensus CDS
-
CCDS5480.1
- UniProtKB/TrEMBL
-
A7LFL1
- Related
- ENSP00000223366.2, ENST00000345378.7
- Conserved Domains (2) summary
-
- COG5026
Location:17 → 459
- COG5026; Hexokinase [Carbohydrate transport and metabolism]
- pfam00349
Location:17 → 216
- Hexokinase_1
-
NM_033508.3 → NP_277043.1 hexokinase-4 isoform 3
See identical proteins and their annotated locations for NP_277043.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) is the minor form expressed in liver. Its first exon is specific to the liver transcripts, variants 2 and 3; its second exon is unique to this transcript. Isoform 3 has a distinct N-terminus; the remainder of the protein is identical to isoforms 1 and 2.
- Source sequence(s)
-
AK122876, CD251038, DA640823, M69051, M90299
- UniProtKB/TrEMBL
-
A7LFL1
- Conserved Domains (2) summary
-
- COG5026
Location:13 → 457
- COG5026; Hexokinase [Carbohydrate transport and metabolism]
- pfam00349
Location:14 → 214
- Hexokinase_1
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000007.14 Reference GRCh38.p14 Primary Assembly
- Range
-
44143213..44189439 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_024446707.2 → XP_024302475.1 hexokinase-4 isoform X1
- Conserved Domains (1) summary
-
- pfam03727
Location:1 → 75
- Hexokinase_2
Alternate T2T-CHM13v2.0
Genomic
-
NC_060931.1 Alternate T2T-CHM13v2.0
- Range
-
44301768..44348026 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054357865.1 → XP_054213840.1 hexokinase-4 isoform X1