CMTR2 cap methyltransferase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CMTR2provided by HGNC
Official Full Name: cap methyltransferase 2provided by HGNC
Primary source: HGNC:HGNC:25635
See related: Ensembl:ENSG00000180917 MIM:616190; AllianceGenome:HGNC:25635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AFT; MTr2; HMTr2; FTSJD1
Summary: Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thyroid (RPKM 7.6), testis (RPKM 6.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q22.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (71281392..71289722, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (77092514..77100845, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (71315295..71323625, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structures of the active CMTr2 catalytic domain in complex with a methyl group donor and a capped oligoribonucleotide are examined, thereby revealing the mechanism of specific recognition of capped RNA.
Title: Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
A report on the validation of a human enzyme that methylates the ribose of the second transcribed nucleotide encoded by FTSJD1.
Title: 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48685 (e-PCR)
- UniSTS:46609

SHGC-63647 (e-PCR)
- UniSTS:34919

SHGC-133070 (e-PCR)
- UniSTS:170999

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA (nucleoside-2'-O-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA (nucleoside-2'-O-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in 7-methylguanosine mRNA capping	IDA Inferred from Direct Assay more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Names: FtsJ methyltransferase domain containing 1; adrift homolog; cap2 2'O-ribose methyltransferase 2; ftsJ methyltransferase domain-containing protein 1; protein adrift homolog

NP_001093112.1

EC 2.1.1.296

NP_001311303.1

EC 2.1.1.296

NP_001311306.1

EC 2.1.1.296

NP_001311307.1

EC 2.1.1.296

NP_001311308.1

EC 2.1.1.296

NP_060818.4

EC 2.1.1.296

XP_011521530.1

EC 2.1.1.296

XP_011521531.1

EC 2.1.1.296

XP_016878933.1

EC 2.1.1.296

XP_047290319.1

EC 2.1.1.296

XP_047290320.1

EC 2.1.1.296

XP_054169443.1

EC 2.1.1.296

XP_054169444.1

EC 2.1.1.296

XP_054169445.1

EC 2.1.1.296

XP_054169446.1

EC 2.1.1.296

XP_054187854.1

EC 2.1.1.296

XP_054187855.1

EC 2.1.1.296

XP_054187856.1

EC 2.1.1.296

XP_054187857.1

EC 2.1.1.296

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099642.2 → NP_001093112.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

See identical proteins and their annotated locations for NP_001093112.1

Status: VALIDATED

Source sequence(s)

AA968997, AC106736, BC034468, DB240113

Consensus CDS

CCDS10898.1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase
NM_001324374.2 → NP_001311303.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Status: VALIDATED

Source sequence(s)

AC106736, BC035005, BX648660

Consensus CDS

CCDS10898.1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Related

ENSP00000337512.5, ENST00000338099.9

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase
NM_001324377.2 → NP_001311306.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Status: VALIDATED

Source sequence(s)

AC106736, BC034468, BU429551, BX648660

Consensus CDS

CCDS10898.1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase
NM_001324378.2 → NP_001311307.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Status: VALIDATED

Source sequence(s)

AC106736, BC034468, BX648660, DB094020

Consensus CDS

CCDS10898.1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase
NM_001324379.2 → NP_001311308.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Status: VALIDATED

Source sequence(s)

AC106736, BX648660

Consensus CDS

CCDS10898.1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase
NM_018348.6 → NP_060818.4 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

See identical proteins and their annotated locations for NP_060818.4

Status: VALIDATED

Source sequence(s)

AA968997, AC106736, BC034468, BC035005, DB227997

Consensus CDS

CCDS10898.1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Related

ENSP00000411148.2, ENST00000434935.7

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

71281392..71289722 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017023444.2 → XP_016878933.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase
XM_047434364.1 → XP_047290320.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5
XM_011523228.2 → XP_011521530.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

See identical proteins and their annotated locations for XP_011521530.1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase
XM_011523229.2 → XP_011521531.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

See identical proteins and their annotated locations for XP_011521531.1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Conserved Domains (1) summary

pfam01728
Location:114 → 320

FtsJ; FtsJ-like methyltransferase
XM_047434363.1 → XP_047290319.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

UniProtKB/Swiss-Prot

B2RCD5, D3DWS1, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5

Reference GRCh38.p14 PATCHES

Genomic

NW_013171813.1 Reference GRCh38.p14 PATCHES

Range

144072..152420 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331882.1 → XP_054187857.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0AAG2UX58
XM_054331881.1 → XP_054187856.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0AAG2UX58
XM_054331879.1 → XP_054187854.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0AAG2UX58
XM_054331880.1 → XP_054187855.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0AAG2UX58

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

77092514..77100845 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054313470.1 → XP_054169445.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1
XM_054313471.1 → XP_054169446.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1
XM_054313468.1 → XP_054169443.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1
XM_054313469.1 → XP_054169444.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1