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    ZDHHC16 zinc finger DHHC-type palmitoyltransferase 16 [ Homo sapiens (human) ]

    Gene ID: 84287, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZDHHC16provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 16provided by HGNC
    Primary source
    HGNC:HGNC:20714
    See related
    Ensembl:ENSG00000171307 MIM:616750; AllianceGenome:HGNC:20714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APH2; DHHC-16
    Summary
    Enables palmitoyltransferase activity. Involved in protein palmitoylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 10.0), lung (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZDHHC16 in Genome Data Viewer
    Location:
    10q24.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97446175..97457370)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98326355..98337553)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99205932..99217127)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr10:99186899-99187121 Neighboring gene phosphoglycerate mutase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99204892-99205472 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99205473-99206052 Neighboring gene exosome component 1 Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99257304-99257834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2680 Neighboring gene ubiquitin domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99277050-99277878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99301395-99302007 Neighboring gene uncharacterized LOC124902488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99302008-99302619 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99311139-99311639 Neighboring gene NANOG hESC enhancer GRCh37_chr10:99313431-99313932

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1. Zhang F, et al. Biochim Biophys Acta, 2006 Nov-Dec. PMID 17123647
    2. SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal Growth Factor Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-Induced DNA Damage. Fan X, et al. Int J Radiat Oncol Biol Phys, 2022 Jul 1. PMID 35192890
    3. METTL3-mediated m6A modification enhances ZDHHC16 expression in nonsmall- cell lung cancer patients, attenuating ferroptosis by suppressing CREB ubiquitination. Liu Z, et al. Cell Mol Biol (Noisy-le-grand), 2024 Feb 29. PMID 38430044
    4. Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. Li B, et al. J Biol Chem, 2002 Aug 9. PMID 12021275
    5. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. Abrami L, et al. Elife, 2017 Aug 15. PMID 28826475, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3-mediated m6A modification enhances ZDHHC16 expression in nonsmall- cell lung cancer patients, attenuating ferroptosis by suppressing CREB ubiquitination.
      Title: METTL3-mediated m6A modification enhances ZDHHC16 expression in nonsmall- cell lung cancer patients, attenuating ferroptosis by suppressing CREB ubiquitination.
    2. SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal Growth Factor Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-Induced DNA Damage.
      Title: SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal Growth Factor Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-Induced DNA Damage.
    3. human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade.
      Title: Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.
    4. APH2 contains a zf-DHHC domain (148-210aa), which is involved in protein-protein or protein-DNA interaction.
      Title: Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2993

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telencephalon development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC16
    Names
    Abl-philin 2
    probable palmitoyltransferase ZDHHC16
    zinc finger DHHC domain-containing protein 16
    zinc finger DHHC-type containing 16
    zinc finger, DHHC domain containing 16
    NP_001274732.1
    NP_001274733.1
    NP_115703.2
    NP_932160.1
    NP_932161.1
    NP_932162.1
    NP_932163.1
    XP_006718087.1
    XP_016872255.1
    XP_016872256.1
    XP_016872257.1
    XP_016872258.1
    XP_016872260.1
    XP_024304001.1
    XP_047281793.1
    XP_047281794.1
    XP_047281795.1
    XP_047281796.1
    XP_047281797.1
    XP_047281798.1
    XP_054222889.1
    XP_054222890.1
    XP_054222891.1
    XP_054222892.1
    XP_054222893.1
    XP_054222894.1
    XP_054222895.1
    XP_054222896.1
    XP_054222897.1
    XP_054222898.1
    XP_054222899.1
    XP_054222900.1
    XP_054222901.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287803.2 → NP_001274732.1  palmitoyltransferase ZDHHC16 isoform 5

      See identical proteins and their annotated locations for NP_001274732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 5, which is shorter than isoform 1.
      Source sequence(s)
      AK297962, BC008074, BM678689, DC399731
      UniProtKB/TrEMBL
      B4DNL2, H0Y6E9
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 231
      DHHC; DHHC palmitoyltransferase

    2. NM_001287804.2 → NP_001274733.1  palmitoyltransferase ZDHHC16 isoform 6

      See identical proteins and their annotated locations for NP_001274733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks three exons in the central and 3' coding regions and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 6, which is shorter than isoform 1.
      Source sequence(s)
      BC008074, BC033157, BM678689, BX353685
      Consensus CDS
      CCDS73176.1
      UniProtKB/TrEMBL
      B1AMU0
      Related
      ENSP00000359883.4, ENST00000370846.8
      Conserved Domains (1) summary
      cl19890
      Location:156 → 185
      DHHC; DHHC palmitoyltransferase

    3. NM_032327.4 → NP_115703.2  palmitoyltransferase ZDHHC16 isoform 1

      See identical proteins and their annotated locations for NP_115703.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1 and 5 encode the same isoform (1), which is the longest isoform.
      Source sequence(s)
      BC012830, BM678689
      Consensus CDS
      CCDS7460.1
      UniProtKB/Swiss-Prot
      D3DR52, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q969W1, Q9BSV3
      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000359891.3, ENST00000370854.7
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 305
      DHHC; DHHC palmitoyltransferase

    4. NM_198043.3 → NP_932160.1  palmitoyltransferase ZDHHC16 isoform 2

      See identical proteins and their annotated locations for NP_932160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 5. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AF258563, BM678689, DC399731
      Consensus CDS
      CCDS7461.1
      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000345383.4, ENST00000352634.8
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 289
      DHHC; DHHC palmitoyltransferase

    5. NM_198044.3 → NP_932161.1  palmitoyltransferase ZDHHC16 isoform 3

      See identical proteins and their annotated locations for NP_932161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and lacks an alternate exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 5. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      BC033157, BM678689, DC399731
      Consensus CDS
      CCDS7462.1
      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000323360.3, ENST00000353979.7
      Conserved Domains (1) summary
      cl19890
      Location:126 → 175
      DHHC; DHHC palmitoyltransferase

    6. NM_198045.3 → NP_932162.1  palmitoyltransferase ZDHHC16 isoform 4

      See identical proteins and their annotated locations for NP_932162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons, one in the 5' coding region and the other in the 3' coding region, compared to variant 5. It encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      BC004535, DC399731
      Consensus CDS
      CCDS7463.1
      UniProtKB/Swiss-Prot
      Q969W1
      Related
      ENSP00000304487.8, ENST00000345745.9
      Conserved Domains (1) summary
      pfam01529
      Location:91 → 224
      zf-DHHC; DHHC palmitoyltransferase

    7. NM_198046.3 → NP_932163.1  palmitoyltransferase ZDHHC16 isoform 1

      See identical proteins and their annotated locations for NP_932163.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. Variants 1 and 5 encode the same isoform (1), which is the longest isoform.
      Source sequence(s)
      AJ294945, AK297962, BM678689, DC399731
      Consensus CDS
      CCDS7460.1
      UniProtKB/Swiss-Prot
      D3DR52, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q969W1, Q9BSV3
      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000377357.1, ENST00000393760.6
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 305
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_109895.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks three internal exons and uses an alternate splice site in an internal exon, compared to variant 5. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 5z.
      Source sequence(s)
      BC004535, BG769550, DC399731

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97446175..97457370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016766.2 → XP_016872255.1  palmitoyltransferase ZDHHC16 isoform X1

      UniProtKB/TrEMBL
      H0Y6E9
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 289
      DHHC; DHHC palmitoyltransferase

    2. XM_047425837.1 → XP_047281793.1  palmitoyltransferase ZDHHC16 isoform X3

    3. XM_017016771.2 → XP_016872260.1  palmitoyltransferase ZDHHC16 isoform X8

      UniProtKB/TrEMBL
      B1AMU0
      Conserved Domains (1) summary
      cl19890
      Location:156 → 185
      DHHC; DHHC palmitoyltransferase

    4. XM_017016768.2 → XP_016872257.1  palmitoyltransferase ZDHHC16 isoform X4

      UniProtKB/TrEMBL
      H0Y6E9
      Conserved Domains (1) summary
      cl19890
      Location:126 → 175
      DHHC; DHHC palmitoyltransferase

    5. XM_047425839.1 → XP_047281795.1  palmitoyltransferase ZDHHC16 isoform X6

    6. XM_047425842.1 → XP_047281798.1  palmitoyltransferase ZDHHC16 isoform X10

    7. XM_006718024.2 → XP_006718087.1  palmitoyltransferase ZDHHC16 isoform X2

      See identical proteins and their annotated locations for XP_006718087.1

      UniProtKB/TrEMBL
      B4DNL2, H0Y6E9
      Related
      ENSP00000396286.1, ENST00000417044.1
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 231
      DHHC; DHHC palmitoyltransferase

    8. XM_017016767.2 → XP_016872256.1  palmitoyltransferase ZDHHC16 isoform X3

      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000405240.1, ENST00000420089.5
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 242
      DHHC; DHHC palmitoyltransferase

    9. XM_047425838.1 → XP_047281794.1  palmitoyltransferase ZDHHC16 isoform X6

    10. XM_017016769.2 → XP_016872258.1  palmitoyltransferase ZDHHC16 isoform X5

      UniProtKB/TrEMBL
      H0Y6E9
      Conserved Domains (1) summary
      cl19890
      Location:156 → 250
      DHHC; DHHC palmitoyltransferase

    11. XM_024448233.2 → XP_024304001.1  palmitoyltransferase ZDHHC16 isoform X7

      Conserved Domains (1) summary
      pfam01529
      Location:91 → 240
      zf-DHHC; DHHC palmitoyltransferase

    12. XM_047425841.1 → XP_047281797.1  palmitoyltransferase ZDHHC16 isoform X10

    13. XM_047425840.1 → XP_047281796.1  palmitoyltransferase ZDHHC16 isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98326355..98337553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366914.1 → XP_054222889.1  palmitoyltransferase ZDHHC16 isoform X1

    2. XM_054366917.1 → XP_054222892.1  palmitoyltransferase ZDHHC16 isoform X3

    3. XM_054366923.1 → XP_054222898.1  palmitoyltransferase ZDHHC16 isoform X8

      UniProtKB/TrEMBL
      B1AMU0

    4. XM_054366918.1 → XP_054222893.1  palmitoyltransferase ZDHHC16 isoform X4

    5. XM_054366921.1 → XP_054222896.1  palmitoyltransferase ZDHHC16 isoform X6

    6. XM_054366926.1 → XP_054222901.1  palmitoyltransferase ZDHHC16 isoform X10

    7. XM_054366915.1 → XP_054222890.1  palmitoyltransferase ZDHHC16 isoform X2

      UniProtKB/TrEMBL
      B4DNL2

    8. XM_054366916.1 → XP_054222891.1  palmitoyltransferase ZDHHC16 isoform X3

    9. XM_054366920.1 → XP_054222895.1  palmitoyltransferase ZDHHC16 isoform X6

    10. XM_054366919.1 → XP_054222894.1  palmitoyltransferase ZDHHC16 isoform X5

    11. XM_054366922.1 → XP_054222897.1  palmitoyltransferase ZDHHC16 isoform X7

    12. XM_054366925.1 → XP_054222900.1  palmitoyltransferase ZDHHC16 isoform X10

    13. XM_054366924.1 → XP_054222899.1  palmitoyltransferase ZDHHC16 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969W1.1 GenPept UniProtKB/Swiss-Prot:Q969W1

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