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    AGBL3 AGBL carboxypeptidase 3 [ Homo sapiens (human) ]

    Gene ID: 340351, updated on 2-Nov-2024

    Summary

    Official Symbol
    AGBL3provided by HGNC
    Official Full Name
    AGBL carboxypeptidase 3provided by HGNC
    Primary source
    HGNC:HGNC:27981
    See related
    Ensembl:ENSG00000146856 MIM:617346; AllianceGenome:HGNC:27981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCP3
    Summary
    Enables metallocarboxypeptidase activity. Involved in protein side chain deglutamylation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 2.0), endometrium (RPKM 0.4) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AGBL3 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (134986508..135135778)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136294285..136443620)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134671259..134820530)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901750 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:134426881-134427534 Neighboring gene tubulin beta 3 class III pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:134469373-134469873 Neighboring gene caldesmon 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134529756-134530955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18675 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134622660-134622865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26701 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:134760279-134760886 Neighboring gene MPRA-validated peak6750 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene cell cycle regulator of NHEJ Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18676 Neighboring gene RNF14 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26710 Neighboring gene transmembrane protein 140 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26712 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134888580-134888794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18677 Neighboring gene microRNA 6509 Neighboring gene WD repeat domain 91

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12983, MGC32955

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein side chain deglutamylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein side chain deglutamylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytosolic carboxypeptidase 3
    Names
    ATP/GTP binding protein like 3
    protein deglutamylase CCP3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001345850.1NP_001332779.1  cytosolic carboxypeptidase 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497
      Conserved Domains (1) summary
      cl11393
      Location:271
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    2. NM_001345851.1NP_001332780.1  cytosolic carboxypeptidase 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497
    3. NM_001345852.1NP_001332781.1  cytosolic carboxypeptidase 3 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform d. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AC083862, AC083870, AC090497
      Conserved Domains (1) summary
      cl11393
      Location:271
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    4. NM_001345853.1NP_001332782.1  cytosolic carboxypeptidase 3 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes isoform d. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AC083862, AC083870, AC090497
      Conserved Domains (1) summary
      cl11393
      Location:271
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    5. NM_001367811.1NP_001354740.1  cytosolic carboxypeptidase 3 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    6. NM_001367812.1NP_001354741.1  cytosolic carboxypeptidase 3 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform f.
      Source sequence(s)
      AC083870, AC090497
      Related
      ENST00000476700.5
    7. NM_001367813.1NP_001354742.1  cytosolic carboxypeptidase 3 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes isoform f.
      Source sequence(s)
      AC083870, AC090497
    8. NM_001367814.1NP_001354743.1  cytosolic carboxypeptidase 3 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497
    9. NM_001367815.1NP_001354744.1  cytosolic carboxypeptidase 3 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    10. NM_001367816.1NP_001354745.1  cytosolic carboxypeptidase 3 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform i.
      Source sequence(s)
      AC083870, AC090497
    11. NM_001367817.1NP_001354746.1  cytosolic carboxypeptidase 3 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform i.
      Source sequence(s)
      AC083870, AC090497
    12. NM_001367818.1NP_001354747.1  cytosolic carboxypeptidase 3 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform i.
      Source sequence(s)
      AC083870, AC090497
      Related
      ENST00000494702.2
    13. NM_001367819.1NP_001354748.1  cytosolic carboxypeptidase 3 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    14. NM_178563.4NP_848658.3  cytosolic carboxypeptidase 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AA707617, AC083862, AC090497, AK302827
      Consensus CDS
      CCDS47718.1
      UniProtKB/Swiss-Prot
      B7Z827, Q8NEM8, Q9H965
      Related
      ENSP00000388275.2, ENST00000436302.6
      Conserved Domains (1) summary
      cd06907
      Location:310570
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins

    RNA

    1. NR_144293.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497
    2. NR_160297.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    3. NR_160298.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    4. NR_160299.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083870
      Related
      ENST00000470839.1
    5. NR_160300.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      134986508..135135778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420319.1XP_047276275.1  cytosolic carboxypeptidase 3 isoform X2

    2. XM_047420318.1XP_047276274.1  cytosolic carboxypeptidase 3 isoform X1

      Related
      ENSP00000401220.2, ENST00000435976.6
    3. XM_047420320.1XP_047276276.1  cytosolic carboxypeptidase 3 isoform X3

      Related
      ENSP00000275763.6, ENST00000275763.10
    4. XM_047420322.1XP_047276278.1  cytosolic carboxypeptidase 3 isoform X5

    5. XM_047420321.1XP_047276277.1  cytosolic carboxypeptidase 3 isoform X4

    6. XM_011516122.4XP_011514424.1  cytosolic carboxypeptidase 3 isoform X6

      Conserved Domains (1) summary
      cl11393
      Location:310502
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      136294285..136443620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358107.1XP_054214082.1  cytosolic carboxypeptidase 3 isoform X2

    2. XM_054358106.1XP_054214081.1  cytosolic carboxypeptidase 3 isoform X1

    3. XM_054358108.1XP_054214083.1  cytosolic carboxypeptidase 3 isoform X3

    4. XM_054358110.1XP_054214085.1  cytosolic carboxypeptidase 3 isoform X5

    5. XM_054358109.1XP_054214084.1  cytosolic carboxypeptidase 3 isoform X4

    6. XM_054358111.1XP_054214086.1  cytosolic carboxypeptidase 3 isoform X6