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    SLC16A14 solute carrier family 16 member 14 [ Homo sapiens (human) ]

    Gene ID: 151473, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SLC16A14provided by HGNC
    Official Full Name
    solute carrier family 16 member 14provided by HGNC
    Primary source
    HGNC:HGNC:26417
    See related
    Ensembl:ENSG00000163053 AllianceGenome:HGNC:26417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT14
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in skin (RPKM 4.6), brain (RPKM 4.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC16A14 in Genome Data Viewer
    Location:
    2q36.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230034982..230068924, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (230517639..230551553, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230899698..230933640, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373924 Neighboring gene F-box protein 36 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:230829825-230830039 Neighboring gene RNA, U6 small nuclear 1027, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:230871505-230871694 Neighboring gene uncharacterized LOC107985996 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:230910722-230911921 Neighboring gene uncharacterized LOC107985995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230932348-230933118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17208 Neighboring gene RNY4 pseudogene 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231005392-231005920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12407 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:231044589-231045131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17209 Neighboring gene SP110 nuclear body protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17210 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:231084625-231084811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17215 Neighboring gene SP140 nuclear body protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231129497-231130018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12408 Neighboring gene MPRA-validated peak4075 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:231176974-231178173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231206345-231206936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17219 Neighboring gene SP140 nuclear body protein like Neighboring gene uncharacterized LOC105373925

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney. Roshanbin S, et al. BMC Neurosci, 2016 Jul 1. PMID 27364523, Free PMC Article
    2. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Halestrap AP, et al. Pflugers Arch, 2004 Feb. PMID 12739169
    3. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Malik S, et al. Cell Cycle, 2016 Aug 17. PMID 27433848, Free PMC Article
    4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30794

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 14
    Names
    MCT 14
    monocarboxylic acid transporter 14
    solute carrier family 16 (monocarboxylic acid transporters), member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152527.5 → NP_689740.2  monocarboxylate transporter 14

      See identical proteins and their annotated locations for NP_689740.2

      Status: VALIDATED

      Source sequence(s)
      AL833470, BC065524, DA044472
      Consensus CDS
      CCDS2473.1
      UniProtKB/Swiss-Prot
      A8KA08, Q53R92, Q7RTX9, Q96NI7
      UniProtKB/TrEMBL
      Q6ZWE5
      Related
      ENSP00000295190.4, ENST00000295190.9
      Conserved Domains (1) summary
      cl26868
      Location:24 → 490
      2A0111; oxalate/formate antiporter family transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      230034982..230068924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246353.5 → XP_005246410.1  monocarboxylate transporter 14 isoform X3

      UniProtKB/TrEMBL
      Q6ZWE5
      Conserved Domains (2) summary
      cd06174
      Location:260 → 442
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:24 → 442
      2A0113; monocarboxylate transporter 1

    2. XM_047443523.1 → XP_047299479.1  monocarboxylate transporter 14 isoform X3

    3. XM_017003480.3 → XP_016858969.1  monocarboxylate transporter 14 isoform X1

      UniProtKB/Swiss-Prot
      A8KA08, Q53R92, Q7RTX9, Q96NI7
      UniProtKB/TrEMBL
      Q6ZWE5
      Conserved Domains (1) summary
      cl26868
      Location:24 → 490
      2A0111; oxalate/formate antiporter family transporter

    4. XM_011510751.4 → XP_011509053.1  monocarboxylate transporter 14 isoform X1

      See identical proteins and their annotated locations for XP_011509053.1

      UniProtKB/Swiss-Prot
      A8KA08, Q53R92, Q7RTX9, Q96NI7
      UniProtKB/TrEMBL
      Q6ZWE5
      Conserved Domains (1) summary
      cl26868
      Location:24 → 490
      2A0111; oxalate/formate antiporter family transporter

    5. XM_011510752.3 → XP_011509054.1  monocarboxylate transporter 14 isoform X2

      UniProtKB/TrEMBL
      Q6ZWE5
      Related
      ENSP00000400352.1, ENST00000457406.5
      Conserved Domains (2) summary
      cd06174
      Location:37 → 461
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:41 → 457
      MFS_1; Major Facilitator Superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      230517639..230551553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340806.1 → XP_054196781.1  monocarboxylate transporter 14 isoform X3

    2. XM_054340807.1 → XP_054196782.1  monocarboxylate transporter 14 isoform X3

    3. XM_054340803.1 → XP_054196778.1  monocarboxylate transporter 14 isoform X1

      UniProtKB/Swiss-Prot
      A8KA08, Q53R92, Q7RTX9, Q96NI7

    4. XM_054340804.1 → XP_054196779.1  monocarboxylate transporter 14 isoform X1

      UniProtKB/Swiss-Prot
      A8KA08, Q53R92, Q7RTX9, Q96NI7

    5. XM_054340805.1 → XP_054196780.1  monocarboxylate transporter 14 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7RTX9.1 GenPept UniProtKB/Swiss-Prot:Q7RTX9

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