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    ICAM2 intercellular adhesion molecule 2 [ Homo sapiens (human) ]

    Gene ID: 3384, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ICAM2provided by HGNC
    Official Full Name
    intercellular adhesion molecule 2provided by HGNC
    Primary source
    HGNC:HGNC:5345
    See related
    Ensembl:ENSG00000108622 MIM:146630; AllianceGenome:HGNC:5345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD102
    Summary
    The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 62.3), placenta (RPKM 26.4) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ICAM2 in Genome Data Viewer
    Location:
    17q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (64002595..64020633, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (64873371..64891380, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62079955..62097993, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62037321-62038319 Neighboring gene uncharacterized LOC105371858 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:62044651-62044849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62045661-62046161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62064225-62064778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62064779-62065330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62075897-62076874 Neighboring gene PRR29 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62083286-62083980 Neighboring gene proline rich 29 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62097827-62098327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12573 Neighboring gene CRISPRi-validated cis-regulatory element chr17.4314 Neighboring gene CRISPRi-validated cis-regulatory element chr17.4315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62132617-62133360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62133361-62134104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8837 Neighboring gene endoplasmic reticulum to nucleus signaling 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12578 Neighboring gene Sharpr-MPRA regulatory region 10488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12586 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62223017-62223571 Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene small nucleolar RNA host gene 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. de Fougerolles AR, et al. J Exp Med, 1991 Jul 1. PMID 1676048, Free PMC Article
    2. Differential expression of cytokines (IL-2, IFN-gamma, IL-10) and adhesion molecules (VCAM-1, LFA-1, CD44) between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis. Yang J, et al. Scand J Immunol, 2002 Sep. PMID 12193230
    3. Recruitment of lymphocytes to the human liver. Lalor PF, et al. Immunol Cell Biol, 2002 Feb. PMID 11869363
    4. N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells. Feduska JM, et al. BMC Cancer, 2013 May 28. PMID 23714211, Free PMC Article
    5. Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily. Casasnovas JM, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077629, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.
      Title: Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.
    2. ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo.
      Title: ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo.
    3. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions.
      Title: Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions.
    4. ICAM2 induction by p53 has a key role in inhibiting cancer cell migration and invasion.ICAM2 acts at least in part through the suppression of the MEK-ERK signaling pathway.
      Title: Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target.
    5. INDEED also identified some candidates previously reported to be relevant to HCC, such as intercellular adhesion molecule 2 (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were missed by both Differential expression and differential network analyses
      Title: INDEED: Integrated differential expression and differential network analysis of omic data for biomarker discovery.
    6. Both ICAM-2 and ICAM-1 levels in plasma were markedly increased in Ankylosing Spondylitis Chinese patients compared to controls.
      Title: Association Between Intercellular Adhesion Molecule-1, -2, -3 Plasma Levels and Disease Activity of Ankylosing Spondylitis in the Chinese Han Population.
    7. Soluble ICAM2 was higher in ADHD patients than in controls.
      Title: Relationship between soluble intercellular adhesion molecules and attention-deficit/hyperactivity disorder.
    8. ICAM-1 and ICAM-2 are involved in each step of neutrophil extravasation, and have redundant but also distinct functions. Analysis of the role of endothelial ICAM-1 requires simultaneous consideration of ICAM-2.
      Title: The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues.
    9. Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells.
      Title: ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin.
    10. with larger patient groups and preferably detailed histopathological and clinical evaluations, are needed to explain the severity of ICAM-1, ICAM-2, and ICAM-3 molecules in Barrett's esophagus
      Title: Investigation of intercellular adhesion molecules (ICAMs) gene expressions in patients with Barrett's esophagus.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ICAM2 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of intercellular adhesion molecule 2 (ICAM2, CD102) PubMed
    Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of intercellular adhesion molecule 2 (ICAM2, CD102) PubMed
    vpu HIV-1 Vpu is identified to have a physical interaction with intercellular adhesion molecule 2 (ICAM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in uropod IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intercellular adhesion molecule 2
    Names
    ICAM-2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000873.4 → NP_000864.2  intercellular adhesion molecule 2 precursor

      See identical proteins and their annotated locations for NP_000864.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
      Source sequence(s)
      AK223219
      Consensus CDS
      CCDS11657.1
      UniProtKB/Swiss-Prot
      P13598, Q14600
      UniProtKB/TrEMBL
      A8KAP5, Q6FHE2
      Related
      ENSP00000392634.2, ENST00000449662.6
      Conserved Domains (2) summary
      cd05755
      Location:112 → 211
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      pfam03921
      Location:24 → 109
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

    2. NM_001099786.2 → NP_001093256.1  intercellular adhesion molecule 2 precursor

      See identical proteins and their annotated locations for NP_001093256.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All 5 variants encode the same protein.
      Source sequence(s)
      AK223219, BX363874, CA841927
      Consensus CDS
      CCDS11657.1
      UniProtKB/Swiss-Prot
      P13598, Q14600
      UniProtKB/TrEMBL
      A8KAP5, Q6FHE2
      Related
      ENSP00000415283.1, ENST00000412356.5
      Conserved Domains (2) summary
      cd05755
      Location:112 → 211
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      pfam03921
      Location:24 → 109
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

    3. NM_001099787.2 → NP_001093257.1  intercellular adhesion molecule 2 precursor

      See identical proteins and their annotated locations for NP_001093257.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
      Source sequence(s)
      AK223219, BX363874, CA841927
      Consensus CDS
      CCDS11657.1
      UniProtKB/Swiss-Prot
      P13598, Q14600
      UniProtKB/TrEMBL
      A8KAP5, Q6FHE2
      Related
      ENSP00000388666.1, ENST00000418105.5
      Conserved Domains (2) summary
      cd05755
      Location:112 → 211
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      pfam03921
      Location:24 → 109
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

    4. NM_001099788.2 → NP_001093258.1  intercellular adhesion molecule 2 precursor

      See identical proteins and their annotated locations for NP_001093258.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
      Source sequence(s)
      AK223219, CA841927
      Consensus CDS
      CCDS11657.1
      UniProtKB/Swiss-Prot
      P13598, Q14600
      UniProtKB/TrEMBL
      A8KAP5, Q6FHE2
      Related
      ENSP00000462579.1, ENST00000579687.5
      Conserved Domains (2) summary
      cd05755
      Location:112 → 211
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      pfam03921
      Location:24 → 109
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

    5. NM_001099789.2 → NP_001093259.1  intercellular adhesion molecule 2 precursor

      See identical proteins and their annotated locations for NP_001093259.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
      Source sequence(s)
      AK223219, CA841927
      Consensus CDS
      CCDS11657.1
      UniProtKB/Swiss-Prot
      P13598, Q14600
      UniProtKB/TrEMBL
      A8KAP5, Q6FHE2
      Related
      ENSP00000464665.1, ENST00000579788.6
      Conserved Domains (2) summary
      cd05755
      Location:112 → 211
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      pfam03921
      Location:24 → 109
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      64002595..64020633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      64873371..64891380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13598.2 GenPept UniProtKB/Swiss-Prot:P13598

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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