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    Tmem131 transmembrane protein 131 [ Mus musculus (house mouse) ]

    Gene ID: 56030, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem131provided by MGI
    Official Full Name
    transmembrane protein 131provided by MGI
    Primary source
    MGI:MGI:1927110
    See related
    Ensembl:ENSMUSG00000026116 AllianceGenome:MGI:1927110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Neg; RW1; CC28; YR-23; mKIAA0257; D1Bwg0491e; 2610524E03Rik
    Summary
    Predicted to enable collagen binding activity. Predicted to be involved in collagen biosynthetic process. Predicted to be active in membrane. Is expressed in cerebral cortex subventricular zone; cortical plate; and thymus primordium. Orthologous to human TMEM131 (transmembrane protein 131). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.9), colon adult (RPKM 15.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem131 in Genome Data Viewer
    Location:
    1 B; 1 15.42 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36831270..36978714, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36792189..36939614, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933424G06 gene Neighboring gene predicted gene, 33533 Neighboring gene STARR-seq mESC enhancer starr_00648 Neighboring gene STARR-positive B cell enhancer ABC_E4309 Neighboring gene predicted gene, 18828 Neighboring gene zeta-chain (TCR) associated protein kinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36854450-36854651 Neighboring gene STARR-seq mESC enhancer starr_00650 Neighboring gene STARR-seq mESC enhancer starr_00652 Neighboring gene STARR-seq mESC enhancer starr_00656 Neighboring gene STARR-seq mESC enhancer starr_00657 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36976691-36976844 Neighboring gene STARR-seq mESC enhancer starr_00660 Neighboring gene ribosomal protein L12, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_00662 Neighboring gene STARR-seq mESC enhancer starr_00663 Neighboring gene STARR-seq mESC enhancer starr_00664 Neighboring gene STARR-positive B cell enhancer mm9_chr1:37057122-37057423 Neighboring gene nuclear encoded rRNA 5S 210

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neg, a nerve growth factor-stimulated gene expressed by fetal neocortical neurons that is downregulated by ethanol. Miller MW, et al. J Comp Neurol, 2003 May 26. PMID 12687686
    2. Use of mRNA differential display to study the action of lymphocyte subsets in vivo and application to a murine model of herpes simplex virus infection. Tscharke DC, et al. Immunol Lett, 2000 Oct 3. PMID 10996388
    3. Sorting nexin-14, a gene expressed in motoneurons trapped by an in vitro preselection method. Carroll P, et al. Dev Dyn, 2001 Aug. PMID 11500980
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 131

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018872.2 → NP_061360.2  transmembrane protein 131 precursor

      See identical proteins and their annotated locations for NP_061360.2

      Status: VALIDATED

      Source sequence(s)
      AB093221, AK012138, AK139317, BE956063, BU058584, CB518500, CD546146, CN533410
      Consensus CDS
      CCDS35538.1
      UniProtKB/Swiss-Prot
      O70472, Q8CHH3
      Related
      ENSMUSP00000027290.6, ENSMUST00000027290.12
      Conserved Domains (1) summary
      pfam12371
      Location:107 → 189
      TMEM131_like; Transmembrane protein 131-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      36831270..36978714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152473.1 → XP_036008366.1  transmembrane protein 131 isoform X3

      Conserved Domains (2) summary
      PTZ00449
      Location:1351 → 1595
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl13764
      Location:107 → 189
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    2. XM_017321814.3 → XP_017177303.1  transmembrane protein 131 isoform X2

      Conserved Domains (2) summary
      PTZ00449
      Location:1351 → 1595
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl13764
      Location:107 → 189
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    3. XM_006496150.4 → XP_006496213.1  transmembrane protein 131 isoform X1

      Conserved Domains (2) summary
      PTZ00449
      Location:1351 → 1648
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl13764
      Location:107 → 189
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    RNA

    1. XR_004933922.1 RNA Sequence

    2. XR_004933916.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70472.2 GenPept UniProtKB/Swiss-Prot:O70472

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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