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    Bicc1 BicC family RNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 83675, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bicc1provided by MGI
    Official Full Name
    BicC family RNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1933388
    See related
    Ensembl:ENSMUSG00000014329 AllianceGenome:MGI:1933388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bpk; jcpk; Bic-C
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within determination of left/right symmetry; heart development; and kidney development. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and heart and pericardium. Used to study autosomal dominant polycystic kidney disease; autosomal recessive polycystic kidney disease; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in diffuse cystic renal dysplasia. Orthologous to human BICC1 (BicC family RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 21.7), ovary adult (RPKM 11.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bicc1 in Genome Data Viewer
    Location:
    10 B5.3; 10 36.75 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (70758660..70995581, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (70922830..71159690, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27101 Neighboring gene STARR-seq mESC enhancer starr_27102 Neighboring gene STARR-seq mESC enhancer starr_27103 Neighboring gene predicted gene, 40689 Neighboring gene RIKEN cDNA 4930533K18 gene Neighboring gene STARR-seq mESC enhancer starr_27108 Neighboring gene predicted gene, 24486 Neighboring gene RIKEN cDNA C730027H18 gene Neighboring gene U6 snRNA-associated Sm-like protein LSm7 pseudogene Neighboring gene thioredoxin-like 4B pseudogene Neighboring gene predicted gene, 34328

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Bicc1 impairs tubulomorphogenesis of cultured IMCD cells by disrupting E-cadherin-based cell-cell adhesion. Fu Y, et al. Eur J Cell Biol, 2010 Jun. PMID 20219263, Free PMC Article
    2. New mouse model for polycystic kidney disease with both recessive and dominant gene effects. Flaherty L, et al. Kidney Int, 1995 Feb. PMID 7723240
    3. A new murine model of autosomal recessive polycystic kidney disease. Ozawa Y, et al. Nihon Jinzo Gakkai Shi, 1993 Apr. PMID 8341011
    4. Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease. Nauta J, et al. Pediatr Nephrol, 1993 Apr. PMID 8476712
    5. Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex. Leal-Esteban LC, et al. PLoS Genet, 2018 Jul. PMID 29995892, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression and Regulatory Network Analysis of BICC1 for Aged Sca-1-Positive Bone Narrow Mesenchymal Stem Cells.
      Title: Expression and Regulatory Network Analysis of BICC1 for Aged Sca-1-Positive Bone Narrow Mesenchymal Stem Cells.
    2. Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
      Title: Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
    3. Study finding that Bicc1 is required for normoglycemia implies that renal gluconeogenesis may be important to inhibit cyst formation.
      Title: Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex.
    4. Polymerization is a novel disease-relevant mechanism both to stabilize Bicc1 and to present associated mRNAs in specific silencing platforms.
      Title: Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA.
    5. discovered that loss of the Pkd1 gene product, polycystin-1 (PC1), whose mutation causes human autosomal dominant polycystic kidney disease (ADPKD), downregulates Bicc1 expression in vitro and in vivo
      Title: Loss of polycystin-1 inhibits Bicc1 expression during mouse development.
    6. identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and suggest that it does so by regulating Pkd2 transcript levels
      Title: Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
    7. Bicc1 similarly induces silencing of the protein kinase inhibitor PKIalpha by miR-27a.
      Title: Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
    8. Bicc1 is a novel regulator of osteoblastogenesis and bone mineral density (BMD)
      Title: Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
    9. Bicc1 KH domains bind the 3' UTRs of AC6 and PKIa mRNAs and cognate miRNA precursors, whereas the SAM domain loads a silencing complex with AGO2. AC6 and PKIa protein levels increase in cystic Bicc1-/- mouse kidneys.
      Title: Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
    10. lack of Bicc1 leads to disruption of normal cell-cell junctions.
      Title: Loss of Bicc1 impairs tubulomorphogenesis of cultured IMCD cells by disrupting E-cadherin-based cell-cell adhesion.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124370

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein bicaudal C homolog 1
    Names
    bicaudal C homolog 1
    juvenile congenital polycystic kidney disease
    polycystic kidney mutation of BALB/c origin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347189.1 → NP_001334118.1  protein bicaudal C homolog 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC079680, AC087891, AK076154, BX637408, CX207788, CX237497
      Consensus CDS
      CCDS83710.1
      UniProtKB/TrEMBL
      G3X8S6
      Related
      ENSMUSP00000014473.6, ENSMUST00000014473.6
      Conserved Domains (4) summary
      cd09520
      Location:875 → 933
      SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily
      cd22420
      Location:48 → 128
      KH-I_BICC1_rpt1; first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
      cd22421
      Location:133 → 202
      KH-I_BICC1_rpt2; second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
      cd22422
      Location:286 → 351
      KH-I_BICC1_rpt3; third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

    2. NM_031397.3 → NP_113574.1  protein bicaudal C homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_113574.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC079680, AC087891, AK076154, BM936635, BX637408, CX207788, CX237497
      Consensus CDS
      CCDS23915.1
      UniProtKB/Swiss-Prot
      Q6P6K3, Q8C286, Q99MQ1
      Related
      ENSMUSP00000123201.2, ENSMUST00000143791.8
      Conserved Domains (3) summary
      cd09520
      Location:875 → 938
      SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily
      smart00454
      Location:878 → 935
      SAM; Sterile alpha motif
      cd02394
      Location:136 → 202
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      70758660..70995581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156124.1 → XP_036012017.1  protein bicaudal C homolog 1 isoform X1

      Conserved Domains (4) summary
      cd09520
      Location:874 → 937
      SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily
      cd22420
      Location:48 → 128
      KH-I_BICC1_rpt1; first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
      cd22421
      Location:133 → 202
      KH-I_BICC1_rpt2; second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
      cd22422
      Location:286 → 351
      KH-I_BICC1_rpt3; third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MQ1.1 GenPept UniProtKB/Swiss-Prot:Q99MQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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