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    Dapp1 dual adaptor for phosphotyrosine and 3-phosphoinositides 1 [ Mus musculus (house mouse) ]

    Gene ID: 26377, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dapp1provided by MGI
    Official Full Name
    dual adaptor for phosphotyrosine and 3-phosphoinositides 1provided by MGI
    Primary source
    MGI:MGI:1347063
    See related
    Ensembl:ENSMUSG00000028159 AllianceGenome:MGI:1347063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bam32
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.5), liver E14 (RPKM 5.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dapp1 in Genome Data Viewer
    Location:
    3 G3; 3 63.98 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137636768..137687331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137931007..137981549, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B14 Neighboring gene STARR-positive B cell enhancer ABC_E9081 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene STARR-positive B cell enhancer ABC_E9226 Neighboring gene predicted gene, 19708 Neighboring gene STARR-seq mESC enhancer starr_09102 Neighboring gene STARR-positive B cell enhancer ABC_E6138 Neighboring gene STARR-positive B cell enhancer ABC_E3472 Neighboring gene STARR-positive B cell enhancer ABC_E1268 Neighboring gene STARR-positive B cell enhancer mm9_chr3:137680066-137680366 Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene predicted gene 5105 Neighboring gene STARR-seq mESC enhancer starr_09105 Neighboring gene predicted gene, 52617

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bam32/DAPP1-Dependent Neutrophil Reactive Oxygen Species in WKYMVm-Induced Microvascular Hyperpermeability. Hao L, et al. Front Immunol, 2020. PMID 32536926, Free PMC Article
    2. A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity. Maazi H, et al. PLoS Genet, 2019 Dec. PMID 31869344, Free PMC Article
    3. LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation. Rouquette-Jazdanian AK, et al. Mol Cell, 2012 Oct 26. PMID 22981863, Free PMC Article
    4. The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responses. Fournier E, et al. Curr Biol, 2003 Oct 28. PMID 14588241
    5. The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain FcɛRI-induced calcium flux and granule release. Hou S, et al. Mol Immunol, 2010 Nov-Dec. PMID 20956018

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment.
      Title: Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment.
    2. Bam32/DAPP1-Dependent Neutrophil Reactive Oxygen Species in WKYMVm-Induced Microvascular Hyperpermeability.
      Title: Bam32/DAPP1-Dependent Neutrophil Reactive Oxygen Species in WKYMVm-Induced Microvascular Hyperpermeability.
    3. Results functionally demonstrated that Dapp1 modulates lung resistance in response to diesel exhaust particles exposure, thus providing evidence for a novel gene-environment interaction that influences asthma-related traits in mice.
      Title: A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity.
    4. These data show that Bam32 is important for optimal anti-trypanosome IgG antibody response and suppression of disease-promoting proinflammatory cytokines.
      Title: The B cell adaptor molecule Bam32 is critically important for optimal antibody response and resistance to Trypanosoma congolense infection in mice.
    5. our results identify Bam32 as a novel regulator of mast cell activation
      Title: The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain FcɛRI-induced calcium flux and granule release.
    6. Bam32 serves to integrate PI3K and Src kinase signaling to promote Rac-dependent B cell adhesive interactions important for Ag presentation function.
      Title: Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells.
    7. Bam32 is not required for germinal center (GC) initiation, but rather functions in a late checkpoint of GC progression associated with T cell recruitment and GC B cell survival.
      Title: The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression.
    8. Data show that Erk activation was diminished in LAT knock-in Bam32 knockout CD4(+) T cells.
      Title: Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
    9. The interaction of Bam32 with Lyn leads to Bam32 phosphorylation, which might play an important role in activating downstream signaling molecules.
      Title: [Identification of proteins interacting with adaptor protein Bam32].
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
    Names
    B-cell adapter molecule of 32 kDa
    b lymphocyte adapter protein Bam32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310753.1 → NP_001297682.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 2

      See identical proteins and their annotated locations for NP_001297682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC146607, AK169584, BF714724
      Consensus CDS
      CCDS80029.1
      UniProtKB/TrEMBL
      Q3TEK6, Q3UL29
      Related
      ENSMUSP00000119634.2, ENSMUST00000136613.4
      Conserved Domains (3) summary
      cd10573
      Location:122 → 217
      PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain
      pfam00169
      Location:125 → 214
      PH; PH domain
      cl15255
      Location:14 → 78
      SH2; Src homology 2 (SH2) domain

    2. NM_011932.3 → NP_036062.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 1

      See identical proteins and their annotated locations for NP_036062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC146607, AK145745, AK169584, BF714724
      Consensus CDS
      CCDS17864.1
      UniProtKB/Swiss-Prot
      Q9QXT1, Q9R178
      UniProtKB/TrEMBL
      Q3UK44, Q3UL29
      Related
      ENSMUSP00000029806.7, ENSMUST00000029806.13
      Conserved Domains (3) summary
      cd10355
      Location:28 → 119
      SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
      cd10573
      Location:163 → 258
      PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain
      pfam00169
      Location:166 → 255
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137636768..137687331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163110.1 → XP_036019003.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X1

      UniProtKB/TrEMBL
      Q3UL29
      Conserved Domains (2) summary
      cd10355
      Location:28 → 119
      SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
      cl17171
      Location:163 → 237
      PH-like; Pleckstrin homology-like domain

    2. XM_017319585.3 → XP_017175074.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

      Conserved Domains (1) summary
      cd10573
      Location:41 → 136
      PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXT1.1 GenPept UniProtKB/Swiss-Prot:Q9QXT1

    Gene LinkOut

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