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    Tbc1d19 TBC1 domain family, member 19 [ Mus musculus (house mouse) ]

    Gene ID: 67249, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tbc1d19provided by MGI
    Official Full Name
    TBC1 domain family, member 19provided by MGI
    Primary source
    MGI:MGI:1914499
    See related
    Ensembl:ENSMUSG00000039178 AllianceGenome:MGI:1914499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810453K03Rik
    Summary
    Is expressed in nervous system. Orthologous to human TBC1D19 (TBC1 domain family member 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 7.7), whole brain E14.5 (RPKM 6.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbc1d19 in Genome Data Viewer
    Location:
    5 C1; 5 29.65 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (53966885..54066563)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (53809543..53909221)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13086 Neighboring gene STARR-seq mESC enhancer starr_13089 Neighboring gene STARR-seq mESC enhancer starr_13090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:53980216-53980325 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region Neighboring gene STARR-seq mESC enhancer starr_13092 Neighboring gene STARR-seq mESC enhancer starr_13095 Neighboring gene cholecystokinin A receptor Neighboring gene STARR-seq mESC enhancer starr_13097 Neighboring gene predicted gene, 40305 Neighboring gene predicted gene, 30601

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144517.4 → NP_653100.1  TBC1 domain family member 19

      See identical proteins and their annotated locations for NP_653100.1

      Status: VALIDATED

      Source sequence(s)
      AK076128, AK083084, BY127335, CK627425
      Consensus CDS
      CCDS19294.1
      UniProtKB/TrEMBL
      Q8VDV7
      Related
      ENSMUSP00000040585.7, ENSMUST00000037337.10
      Conserved Domains (1) summary
      smart00164
      Location:248 → 466
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      53966885..54066563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165432.1 → XP_036021325.1  TBC1 domain family member 19 isoform X1

      Conserved Domains (1) summary
      cl02495
      Location:277 → 495
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. XM_006504065.4 → XP_006504128.1  TBC1 domain family member 19 isoform X2

      Conserved Domains (1) summary
      smart00164
      Location:155 → 373
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    3. XM_030254772.1 → XP_030110632.1  TBC1 domain family member 19 isoform X2

      Conserved Domains (1) summary
      smart00164
      Location:155 → 373
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    4. XM_006504067.4 → XP_006504130.1  TBC1 domain family member 19 isoform X4

      Conserved Domains (1) summary
      smart00164
      Location:79 → 297
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    5. XM_017321077.1 → XP_017176566.1  TBC1 domain family member 19 isoform X4

      Conserved Domains (1) summary
      smart00164
      Location:79 → 297
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    6. XM_036165433.1 → XP_036021326.1  TBC1 domain family member 19 isoform X3

      Conserved Domains (1) summary
      cl02495
      Location:118 → 336
      RabGAP-TBC; Rab-GTPase-TBC domain

    RNA

    1. XR_004942551.1 RNA Sequence

    2. XR_004942552.1 RNA Sequence

    3. XR_003955697.2 RNA Sequence

      Related
      ENSMUST00000201958.4
    Nucleotide Protein Strain
    Heading Accession and Version

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