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    LPP-AS2 LPP antisense RNA 2 [ Homo sapiens (human) ]

    Gene ID: 339929, updated on 22-Oct-2024

    Summary

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    Official Symbol
    LPP-AS2provided by HGNC
    Official Full Name
    LPP antisense RNA 2provided by HGNC
    Primary source
    HGNC:HGNC:27952
    See related
    Ensembl:ENSG00000270959 AllianceGenome:HGNC:27952
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYCLo-5; MYCLo-6
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    Genomic context

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    See LPP-AS2 in Genome Data Viewer
    Location:
    3q27.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (188151206..188154088, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (190968728..190971611, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187868994..187871876, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20974 Neighboring gene Sharpr-MPRA regulatory region 2895 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:187707584-187708117 Neighboring gene uncharacterized LOC107986166 Neighboring gene long intergenic non-protein coding RNA 1991 Neighboring gene Sharpr-MPRA regulatory region 1686 Neighboring gene Sharpr-MPRA regulatory region 10187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:187769983-187770955 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:187870480-187871380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:187873180-187874078 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:187882030-187883229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:187897095-187897707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20975 Neighboring gene uncharacterized LOC401105 Neighboring gene LIM domain containing preferred translocation partner in lipoma Neighboring gene Sharpr-MPRA regulatory region 910 Neighboring gene LPP antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression. Kim T, et al. Oncotarget, 2015 Aug 7. PMID 26003165, Free PMC Article
    2. Long Non-Coding RNA LPP-AS2 Plays an Anti-Tumor Role in Thyroid Carcinoma by Regulating the miR-132-3p/OLFM1 Axis. Zhang B, et al. Crit Rev Eukaryot Gene Expr, 2023. PMID 37199315
    3. Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop. Zhang X, et al. J Exp Clin Cancer Res, 2020 Sep 22. PMID 32962742, Free PMC Article
    4. Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. Kim T, et al. J Natl Cancer Inst, 2015 Apr. PMID 25663692, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Non-Coding RNA LPP-AS2 Plays an Anti-Tumor Role in Thyroid Carcinoma by Regulating the miR-132-3p/OLFM1 Axis.
      Title: Long Non-Coding RNA LPP-AS2 Plays an Anti-Tumor Role in Thyroid Carcinoma by Regulating the miR-132-3p/OLFM1 Axis.
    2. Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop.
      Title: Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • LPP antisense RNA 2 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_036497.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022498, BC042414
      Related
      ENST00000605573.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      188151206..188154088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      190968728..190971611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials