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    DOP1A DOP1 leucine zipper like protein A [ Homo sapiens (human) ]

    Gene ID: 23033, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DOP1Aprovided by HGNC
    Official Full Name
    DOP1 leucine zipper like protein Aprovided by HGNC
    Primary source
    HGNC:HGNC:21194
    See related
    Ensembl:ENSG00000083097 MIM:616823; AllianceGenome:HGNC:21194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOP1; DOPEY1; KIAA1117; dJ202D23.2
    Summary
    Predicted to be involved in Golgi to endosome transport and endoplasmic reticulum organization. Predicted to be located in Golgi membrane. Predicted to be active in endosome and trans-Golgi network. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DOP1A in Genome Data Viewer
    Location:
    6q14.1
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83067671..83171350)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84290676..84394587)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83777390..83881069)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377877 Neighboring gene MPRA-validated peak5926 silencer Neighboring gene ubiquitin protein ligase E3D Neighboring gene leucine aminopeptidase 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:83710771-83710962 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:83747652-83748851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24783 Neighboring gene NANOG hESC enhancer GRCh37_chr6:83821047-83821571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17356 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:83902947-83903446 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene MPRA-validated peak5928 silencer Neighboring gene malic enzyme 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:84004031-84004257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17358

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Diagnostic significance of alternative splice variants of REST and DOPEY1 in the peripheral blood of patients with breast cancer. Lend AK, et al. Tumour Biol, 2015 Apr. PMID 25424701
    2. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. Pascon RC, et al. Mol Microbiol, 2000 Jun. PMID 10931277
    3. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. Gillingham AK, et al. J Biol Chem, 2006 Jan 27. PMID 16301316
    4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Kikuno R, et al. DNA Res, 1999 Jun 30. PMID 10470851
    5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35610

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi-associated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein DOP1A; protein dopey-1
    Names
    dopey family member 1
    homolog of yeast DOP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199942.2 → NP_001186871.1  protein DOP1A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and has an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is longer compared to isoform a.
      Source sequence(s)
      AL121716, AL139333
      Consensus CDS
      CCDS64467.1
      UniProtKB/TrEMBL
      B2RWN9, F6U2K4, Q5TA12
      Related
      ENSP00000237163.6, ENST00000237163.9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2082 → 2318
      Dopey_N; Dopey, N-terminal

    2. NM_001385856.1 → NP_001372785.1  protein DOP1A isoform c

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2081 → 2317
      Dopey_N; Dopey, N-terminal

    3. NM_001385857.1 → NP_001372786.1  protein DOP1A isoform c

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2081 → 2317
      Dopey_N; Dopey, N-terminal

    4. NM_001385858.1 → NP_001372787.1  protein DOP1A isoform e

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (1) summary
      cl04407
      Location:1 → 146
      Dopey_N; Dopey, N-terminal

    5. NM_001385859.1 → NP_001372788.1  protein DOP1A isoform f

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (1) summary
      cl04407
      Location:1816 → 1976
      Dopey_N; Dopey, N-terminal

    6. NM_001385860.1 → NP_001372789.1  protein DOP1A isoform c

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2081 → 2317
      Dopey_N; Dopey, N-terminal

    7. NM_001385861.1 → NP_001372790.1  protein DOP1A isoform c

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2081 → 2317
      Dopey_N; Dopey, N-terminal

    8. NM_001385863.1 → NP_001372792.1  protein DOP1A isoform b

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      Consensus CDS
      CCDS64467.1
      UniProtKB/TrEMBL
      B2RWN9, F6U2K4, Q5TA12
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2082 → 2318
      Dopey_N; Dopey, N-terminal

    9. NM_001385864.1 → NP_001372793.1  protein DOP1A isoform g

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      Conserved Domains (1) summary
      cl04407
      Location:1579 → 1815
      Dopey_N; Dopey, N-terminal

    10. NM_001385865.1 → NP_001372794.1  protein DOP1A isoform d

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2082 → 2318
      Dopey_N; Dopey, N-terminal

    11. NM_015018.4 → NP_055833.2  protein DOP1A isoform a

      See identical proteins and their annotated locations for NP_055833.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform a).
      Source sequence(s)
      AL121716, AL139333
      Consensus CDS
      CCDS4996.1
      UniProtKB/Swiss-Prot
      Q5JWR5, Q86XV1, Q9H5J5, Q9NSL4, Q9UPN5, Q9Y414
      UniProtKB/TrEMBL
      B2RWN9
      Related
      ENSP00000195654.3, ENST00000349129.7
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 299
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2091 → 2327
      Dopey_N; Dopey, N-terminal

    RNA

    1. NR_169790.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333

    2. NR_169791.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121716, AL139333

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      83067671..83171350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010559.2 → XP_016866048.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      B2RWN9

    2. XM_017010564.2 → XP_016866053.1  protein dopey-1 isoform X5

      UniProtKB/Swiss-Prot
      Q5JWR5, Q86XV1, Q9H5J5, Q9NSL4, Q9UPN5, Q9Y414
      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 299
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2091 → 2327
      Dopey_N; Dopey, N-terminal

    3. XM_017010572.2 → XP_016866061.1  protein dopey-1 isoform X11

      UniProtKB/TrEMBL
      B2RWN9

    4. XM_047418447.1 → XP_047274403.1  protein dopey-1 isoform X15

    5. XM_047418448.1 → XP_047274404.1  protein dopey-1 isoform X15

    6. XM_017010571.2 → XP_016866060.1  protein dopey-1 isoform X9

      UniProtKB/TrEMBL
      B2RWN9

    7. XM_047418442.1 → XP_047274398.1  protein dopey-1 isoform X12

    8. XM_047418443.1 → XP_047274399.1  protein dopey-1 isoform X12

    9. XM_047418451.1 → XP_047274407.1  protein dopey-1 isoform X18

    10. XM_011535619.3 → XP_011533921.1  protein dopey-1 isoform X3

      See identical proteins and their annotated locations for XP_011533921.1

      UniProtKB/TrEMBL
      B2RWN9
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 299
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2081 → 2317
      Dopey_N; Dopey, N-terminal

    11. XM_047418434.1 → XP_047274390.1  protein dopey-1 isoform X7

    12. XM_017010561.2 → XP_016866050.1  protein dopey-1 isoform X2

      UniProtKB/TrEMBL
      B2RWN9, F6U2K4, Q5TA12
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2082 → 2318
      Dopey_N; Dopey, N-terminal

    13. XM_017010570.2 → XP_016866059.1  protein dopey-1 isoform X8

      UniProtKB/TrEMBL
      B2RWN9

    14. XM_047418440.1 → XP_047274396.1  protein dopey-1 isoform X10

    15. XM_047418445.1 → XP_047274401.1  protein dopey-1 isoform X13

    16. XM_047418450.1 → XP_047274406.1  protein dopey-1 isoform X17

    17. XM_017010560.3 → XP_016866049.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      B2RWN9

    18. XM_047418430.1 → XP_047274386.1  protein dopey-1 isoform X3

    19. XM_047418435.1 → XP_047274391.1  protein dopey-1 isoform X7

    20. XM_047418449.1 → XP_047274405.1  protein dopey-1 isoform X16

    21. XM_047418446.1 → XP_047274402.1  protein dopey-1 isoform X14

    22. XM_017010562.3 → XP_016866051.1  protein dopey-1 isoform X2

      UniProtKB/TrEMBL
      B2RWN9, F6U2K4, Q5TA12
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 295
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2082 → 2318
      Dopey_N; Dopey, N-terminal

    23. XM_047418433.1 → XP_047274389.1  protein dopey-1 isoform X6

    24. XM_047418432.1 → XP_047274388.1  protein dopey-1 isoform X4

    25. XM_047418438.1 → XP_047274394.1  protein dopey-1 isoform X8

    26. XM_047418439.1 → XP_047274395.1  protein dopey-1 isoform X10

    27. XM_047418444.1 → XP_047274400.1  protein dopey-1 isoform X13

    28. XM_047418452.1 → XP_047274408.1  protein dopey-1 isoform X19

    29. XM_047418453.1 → XP_047274409.1  protein dopey-1 isoform X20

    30. XM_047418455.1 → XP_047274411.1  protein dopey-1 isoform X24

    31. XM_017010573.1 → XP_016866062.1  protein dopey-1 isoform X21

      UniProtKB/TrEMBL
      B2RWN9

    32. XM_017010574.1 → XP_016866063.1  protein dopey-1 isoform X22

      UniProtKB/TrEMBL
      B2RWN9

    33. XM_047418454.1 → XP_047274410.1  protein dopey-1 isoform X23

    34. XM_047418428.1 → XP_047274384.1  protein dopey-1 isoform X1

    35. XM_047418431.1 → XP_047274387.1  protein dopey-1 isoform X3

    36. XM_047418436.1 → XP_047274392.1  protein dopey-1 isoform X7

    37. XM_047418441.1 → XP_047274397.1  protein dopey-1 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      84290676..84394587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354754.1 → XP_054210729.1  protein dopey-1 isoform X1

    2. XM_054354763.1 → XP_054210738.1  protein dopey-1 isoform X5

    3. XM_054354774.1 → XP_054210749.1  protein dopey-1 isoform X11

    4. XM_054354780.1 → XP_054210755.1  protein dopey-1 isoform X15

    5. XM_054354781.1 → XP_054210756.1  protein dopey-1 isoform X15

    6. XM_054354770.1 → XP_054210745.1  protein dopey-1 isoform X9

    7. XM_054354775.1 → XP_054210750.1  protein dopey-1 isoform X12

    8. XM_054354776.1 → XP_054210751.1  protein dopey-1 isoform X12

    9. XM_054354784.1 → XP_054210759.1  protein dopey-1 isoform X18

    10. XM_054354759.1 → XP_054210734.1  protein dopey-1 isoform X3

    11. XM_054354765.1 → XP_054210740.1  protein dopey-1 isoform X7

    12. XM_054354757.1 → XP_054210732.1  protein dopey-1 isoform X2

    13. XM_054354768.1 → XP_054210743.1  protein dopey-1 isoform X8

    14. XM_054354772.1 → XP_054210747.1  protein dopey-1 isoform X10

    15. XM_054354778.1 → XP_054210753.1  protein dopey-1 isoform X13

    16. XM_054354783.1 → XP_054210758.1  protein dopey-1 isoform X17

    17. XM_054354755.1 → XP_054210730.1  protein dopey-1 isoform X1

    18. XM_054354760.1 → XP_054210735.1  protein dopey-1 isoform X3

    19. XM_054354766.1 → XP_054210741.1  protein dopey-1 isoform X7

    20. XM_054354782.1 → XP_054210757.1  protein dopey-1 isoform X16

    21. XM_054354779.1 → XP_054210754.1  protein dopey-1 isoform X14

    22. XM_054354758.1 → XP_054210733.1  protein dopey-1 isoform X2

    23. XM_054354764.1 → XP_054210739.1  protein dopey-1 isoform X6

    24. XM_054354762.1 → XP_054210737.1  protein dopey-1 isoform X4

    25. XM_054354769.1 → XP_054210744.1  protein dopey-1 isoform X8

    26. XM_054354771.1 → XP_054210746.1  protein dopey-1 isoform X10

    27. XM_054354777.1 → XP_054210752.1  protein dopey-1 isoform X13

    28. XM_054354785.1 → XP_054210760.1  protein dopey-1 isoform X19

    29. XM_054354786.1 → XP_054210761.1  protein dopey-1 isoform X20

    30. XM_054354790.1 → XP_054210765.1  protein dopey-1 isoform X24

    31. XM_054354787.1 → XP_054210762.1  protein dopey-1 isoform X21

    32. XM_054354788.1 → XP_054210763.1  protein dopey-1 isoform X22

    33. XM_054354789.1 → XP_054210764.1  protein dopey-1 isoform X23

    34. XM_054354756.1 → XP_054210731.1  protein dopey-1 isoform X1

    35. XM_054354761.1 → XP_054210736.1  protein dopey-1 isoform X3

    36. XM_054354767.1 → XP_054210742.1  protein dopey-1 isoform X7

    37. XM_054354773.1 → XP_054210748.1  protein dopey-1 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JWR5.1 GenPept UniProtKB/Swiss-Prot:Q5JWR5

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