ACBD5 acyl-CoA binding domain containing 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ACBD5provided by HGNC
Official Full Name: acyl-CoA binding domain containing 5provided by HGNC
Primary source: HGNC:HGNC:23338
See related: Ensembl:ENSG00000107897 MIM:616618; AllianceGenome:HGNC:23338
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RDLKD
Summary: This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression: Ubiquitous expression in brain (RPKM 6.3), kidney (RPKM 5.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p12.1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (27182838..27242111, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (27212829..27273060, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (27471767..27531040, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential roles for ACBD4 and ACBD5 in peroxisome-ER interactions and lipid metabolism.
Title: Differential roles for ACBD4 and ACBD5 in peroxisome-ER interactions and lipid metabolism.
Newly defined peroxisomal disease with novel ACBD5 mutation.
Title: Newly defined peroxisomal disease with novel ACBD5 mutation.
Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3beta.
Title: Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β.
First reported adult patient with retinal dystrophy and leukodystrophy caused by a novel ACBD5 variant: A case report and review of literature.
Title: First reported adult patient with retinal dystrophy and leukodystrophy caused by a novel ACBD5 variant: A case report and review of literature.
Peroxisomal (PO) long range movements were largely diminished in response to human ACBD5 overexpression in primary mouse hippocampal neurons. PO localization significantly changed in ACBD5-transfected neurons, PO numbers in neurites increased, while PO density in the soma was decreased. Alterations in PO motility and distribution in the hippocampal neurons were independent of the interaction between ACBD5 and mouse Vapb.
Title: Intracellular redistribution of neuronal peroxisomes in response to ACBD5 expression.
ACBD5 captures VLC-CoAs on the cytosolic side of the peroxisomal membrane so that the transport of VLC-CoAs into peroxisomes and subsequent beta-oxidation thereof can proceed efficiently.
Title: Deficiency of a Retinal Dystrophy Protein, Acyl-CoA Binding Domain-containing 5 (ACBD5), Impairs Peroxisomal β-Oxidation of Very-long-chain Fatty Acids.
VAP-ACBD5-mediated contact between the endoplasmic reticulum and peroxisomes mediate organelle maintenance and lipid homeostasis.
Title: VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis.
ACBD5-VAPB interaction regulates peroxisome-endoplasmic reticulum associations. Loss of PO-ER association perturbs PO membrane expansion and increases PO movement.
Title: ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER.
Findings suggest that the ACBD5-RET rearrangement is causatively involved in the development of papillary thyroid cancer.
Title: A novel RET rearrangement (ACBD5/RET) by pericentric inversion, inv(10)(p12.1;q11.2), in papillary thyroid cancer from an atomic bomb survivor exposed to high-dose radiation.
Yeast Atg37, which is homologous to human ACBD5, is involved in autophagy of peroxisomes.
Title: Atg37 regulates the assembly of the pexophagic receptor protein complex.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Retinal dystrophy with leukodystrophy MedGen: C5394315 OMIM: 618863 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr is identified to have a physical interaction with acyl-CoA binding domain containing 5 (ACBD5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-155089 (e-PCR)
- UniSTS:182286

D11S2560 (e-PCR)
- UniSTS:37928

D10S291 (e-PCR)
- UniSTS:148012

D10S298 (e-PCR)
- UniSTS:148020

D10S303 (e-PCR)
- UniSTS:148024

STS-H57537 (e-PCR)
- UniSTS:29510

D10S1733 (e-PCR)
- UniSTS:18868

RH123807 (e-PCR)
- UniSTS:136128

G32339 (e-PCR)
- UniSTS:116931

A006F35 (e-PCR)
- UniSTS:36074

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in peroxisomal membrane	TAS Traceable Author Statement more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acyl-CoA-binding domain-containing protein 5

Names: acyl-Coenzyme A binding domain containing 5; endozepine-related protein; membrane-associated diazepam binding inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032960.4 RefSeqGene

Range

6314..51897

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042473.4 → NP_001035938.1 acyl-CoA-binding domain-containing protein 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 17-19 all encode the same isoform (2).

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS7154.1

UniProtKB/TrEMBL

A0A7I2V2Y9

Related

ENSP00000365070.4, ENST00000375905.8

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001271512.3 → NP_001258441.1 acyl-CoA-binding domain-containing protein 5 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, which results in translation initiation from an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB082527, AI453384, AK294510, AK295031, BP200763, DC333870

Consensus CDS

CCDS73079.1

UniProtKB/TrEMBL

A0A7I2V2Y9, B7Z2R7

Related

ENSP00000365062.4, ENST00000375897.7

Conserved Domains (1) summary

cd00435
Location:41 → 129

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001301251.2 → NP_001288180.1 acyl-CoA-binding domain-containing protein 5 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 3, 5, 7, 23, and 24 all encode the same isoform (4).

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS76290.1

UniProtKB/TrEMBL

B7Z9D0

Related

ENSP00000365066.1, ENST00000375901.5

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001301252.2 → NP_001288181.1 acyl-CoA-binding domain-containing protein 5 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 3, 5, 7, 23, and 24 all encode the same isoform (4).

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS76290.1

UniProtKB/TrEMBL

B7Z9D0

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001301253.2 → NP_001288182.1 acyl-CoA-binding domain-containing protein 5 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 3, 5, 7, 23, and 24 all encode the same isoform (4).

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS76290.1

UniProtKB/TrEMBL

B7Z9D0

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001301254.2 → NP_001288183.1 acyl-CoA-binding domain-containing protein 5 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks part of the 5' coding region, lacks an in-frame exon in the central coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1.

Source sequence(s)

AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2YQS1, B7Z2A7

Related

ENSP00000504374.1, ENST00000677901.1

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352568.1 → NP_001339497.1 acyl-CoA-binding domain-containing protein 5 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (8) encodes the longest isoform (6).

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2YQJ9

Conserved Domains (1) summary

cd00435
Location:50 → 138

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352569.1 → NP_001339498.1 acyl-CoA-binding domain-containing protein 5 isoform 7

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2YQJ9

Conserved Domains (1) summary

cd00435
Location:43 → 131

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352570.1 → NP_001339499.1 acyl-CoA-binding domain-containing protein 5 isoform 8

Status: REVIEWED

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS91230.1

UniProtKB/TrEMBL

A0A7I2V2Y9, A0A7I2YQE9

Related

ENSP00000503467.1, ENST00000676997.1

Conserved Domains (1) summary

cd00435
Location:43 → 131

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352571.1 → NP_001339500.1 acyl-CoA-binding domain-containing protein 5 isoform 19

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

Consensus CDS

CCDS86078.1

UniProtKB/Swiss-Prot

B3KQ56, D3DRW0, Q5T8D3, Q5T8D4, Q5T8E1, Q5T8E2, Q86UV1, Q8N6E3, Q9UFB5

UniProtKB/TrEMBL

A0A7I2YQJ9

Related

ENSP00000365049.1, ENST00000375888.5

Conserved Domains (1) summary

cd00435
Location:41 → 129

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352572.1 → NP_001339501.1 acyl-CoA-binding domain-containing protein 5 isoform 9

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2V2Y9

Conserved Domains (1) summary

cd00435
Location:50 → 138

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352573.1 → NP_001339502.1 acyl-CoA-binding domain-containing protein 5 isoform 10

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2YQJ9

Conserved Domains (1) summary

cd00435
Location:43 → 131

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352574.2 → NP_001339503.1 acyl-CoA-binding domain-containing protein 5 isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variants 15 and 16, encodes isoform 11.

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS91229.1

UniProtKB/TrEMBL

A0A7I2V347, A0A7I2YQJ9

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352575.2 → NP_001339504.1 acyl-CoA-binding domain-containing protein 5 isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform 11.

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS91229.1

UniProtKB/TrEMBL

A0A7I2V347, A0A7I2YQJ9

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352576.2 → NP_001339505.1 acyl-CoA-binding domain-containing protein 5 isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (16), as well as variants 14 and 15, encodes isoform 11.

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS91229.1

UniProtKB/TrEMBL

A0A7I2V347, A0A7I2YQJ9

Related

ENSP00000503264.1, ENST00000677509.1

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352577.2 → NP_001339506.1 acyl-CoA-binding domain-containing protein 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (17), as well as variants 2, 18, and 19, encodes isoform 2.

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS7154.1

UniProtKB/TrEMBL

A0A7I2V2Y9

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352578.2 → NP_001339507.1 acyl-CoA-binding domain-containing protein 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (18), as well as variants 2, 17, and 19, encodes isoform 2.

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS7154.1

UniProtKB/TrEMBL

A0A7I2V2Y9

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352579.2 → NP_001339508.1 acyl-CoA-binding domain-containing protein 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (19), as well as variants 2, 17, and 18, encodes isoform 2.

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS7154.1

UniProtKB/TrEMBL

A0A7I2V2Y9

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352580.2 → NP_001339509.1 acyl-CoA-binding domain-containing protein 5 isoform 12

Status: REVIEWED

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS91226.1

UniProtKB/TrEMBL

A0A7I2V2M2, A0A7I2V2Y9

Related

ENSP00000502986.1, ENST00000679220.1

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352581.1 → NP_001339510.1 acyl-CoA-binding domain-containing protein 5 isoform 13

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2YQJ9

Conserved Domains (1) summary

cd00435
Location:43 → 131

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352582.2 → NP_001339511.1 acyl-CoA-binding domain-containing protein 5 isoform 14

Status: REVIEWED

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS91227.1

UniProtKB/TrEMBL

A0A7I2V2Y9, A0A7I2V690

Related

ENSP00000503800.1, ENST00000678446.1

Conserved Domains (1) summary

cd00435
Location:8 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352583.1 → NP_001339512.1 acyl-CoA-binding domain-containing protein 5 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (23), as well as variants 3, 5, 7, and 24, encodes isoform 4.

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

Consensus CDS

CCDS76290.1

UniProtKB/TrEMBL

B7Z9D0

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352584.1 → NP_001339513.1 acyl-CoA-binding domain-containing protein 5 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (24), as well as variants 3, 5, 7, and 23, encodes isoform 4.

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

Consensus CDS

CCDS76290.1

UniProtKB/TrEMBL

B7Z9D0

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352585.1 → NP_001339514.1 acyl-CoA-binding domain-containing protein 5 isoform 15

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2V5L4

Related

ENSP00000504580.1, ENST00000677440.1

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352586.1 → NP_001339515.1 acyl-CoA-binding domain-containing protein 5 isoform 16

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2YQJ9

Related

ENSP00000504029.1, ENST00000676732.1

Conserved Domains (1) summary

cd00435
Location:41 → 129

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352587.1 → NP_001339516.1 acyl-CoA-binding domain-containing protein 5 isoform 17

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2V2Y9

Related

ENSP00000504726.1, ENST00000677960.1

Conserved Domains (1) summary

cd00435
Location:41 → 129

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001352588.1 → NP_001339517.1 acyl-CoA-binding domain-containing protein 5 isoform 18

Status: REVIEWED

Source sequence(s)

AI453384, AL133064, AL160291, KF459530

UniProtKB/TrEMBL

A0A7I2V2Y9

Conserved Domains (1) summary

cd00435
Location:43 → 131

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_145698.5 → NP_663736.2 acyl-CoA-binding domain-containing protein 5 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AL160291, KF459530

Consensus CDS

CCDS44368.1

UniProtKB/TrEMBL

A0A7I2V2Y9

Related

ENSP00000379568.3, ENST00000396271.8

Conserved Domains (1) summary

cd00435
Location:43 → 131

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

27182838..27242111 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017016893.3 → XP_016872382.2 acyl-CoA-binding domain-containing protein 5 isoform X6
XM_017016885.3 → XP_016872374.2 acyl-CoA-binding domain-containing protein 5 isoform X10
XM_017016890.3 → XP_016872379.2 acyl-CoA-binding domain-containing protein 5 isoform X4
XM_017016884.3 → XP_016872373.2 acyl-CoA-binding domain-containing protein 5 isoform X9

Related

ENSP00000504333.1, ENST00000676511.1
XM_017016896.2 → XP_016872385.1 acyl-CoA-binding domain-containing protein 5 isoform X10

UniProtKB/TrEMBL

A0A7I2V2Y9

Related

ENSP00000503158.1, ENST00000676731.1
XM_017016895.3 → XP_016872384.1 acyl-CoA-binding domain-containing protein 5 isoform X9

UniProtKB/TrEMBL

A0A7I2V560
XM_047425993.1 → XP_047281949.1 acyl-CoA-binding domain-containing protein 5 isoform X15
XM_017016889.3 → XP_016872378.1 acyl-CoA-binding domain-containing protein 5 isoform X3

UniProtKB/TrEMBL

A0A7I2V2Y9
XM_017016887.3 → XP_016872376.1 acyl-CoA-binding domain-containing protein 5 isoform X1

UniProtKB/TrEMBL

A0A7I2V560
XM_017016898.3 → XP_016872387.1 acyl-CoA-binding domain-containing protein 5 isoform X13

UniProtKB/TrEMBL

A0A7I2V2Y9
XM_024448248.2 → XP_024304016.1 acyl-CoA-binding domain-containing protein 5 isoform X11

UniProtKB/TrEMBL

A0A7I2V560

Conserved Domains (1) summary

cd00435
Location:43 → 131

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
XM_017016888.3 → XP_016872377.1 acyl-CoA-binding domain-containing protein 5 isoform X2

UniProtKB/TrEMBL

A0A7I2V560
XM_017016894.3 → XP_016872383.2 acyl-CoA-binding domain-containing protein 5 isoform X8

UniProtKB/TrEMBL

A0A7I2V690
XM_047425994.1 → XP_047281950.1 acyl-CoA-binding domain-containing protein 5 isoform X5

UniProtKB/TrEMBL

A0A7I2V556
XM_047425995.1 → XP_047281951.1 acyl-CoA-binding domain-containing protein 5 isoform X7
XM_024448249.2 → XP_024304017.1 acyl-CoA-binding domain-containing protein 5 isoform X14

UniProtKB/TrEMBL

A0A7I2V2Y9

Conserved Domains (1) summary

cd00435
Location:50 → 138

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
XM_047425996.1 → XP_047281952.1 acyl-CoA-binding domain-containing protein 5 isoform X12

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

27212829..27273060 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367132.1 → XP_054223107.1 acyl-CoA-binding domain-containing protein 5 isoform X6
XM_054367130.1 → XP_054223105.1 acyl-CoA-binding domain-containing protein 5 isoform X4
XM_054367136.1 → XP_054223111.1 acyl-CoA-binding domain-containing protein 5 isoform X10
XM_054367135.1 → XP_054223110.1 acyl-CoA-binding domain-containing protein 5 isoform X9
XM_054367129.1 → XP_054223104.1 acyl-CoA-binding domain-containing protein 5 isoform X3
XM_054367127.1 → XP_054223102.1 acyl-CoA-binding domain-containing protein 5 isoform X1
XM_054367139.1 → XP_054223114.1 acyl-CoA-binding domain-containing protein 5 isoform X13
XM_054367137.1 → XP_054223112.1 acyl-CoA-binding domain-containing protein 5 isoform X11
XM_054367128.1 → XP_054223103.1 acyl-CoA-binding domain-containing protein 5 isoform X2
XM_054367125.1 → XP_054223100.1 acyl-CoA-binding domain-containing protein 5 isoform X16
XM_054367126.1 → XP_054223101.1 acyl-CoA-binding domain-containing protein 5 isoform X17
XM_054367134.1 → XP_054223109.1 acyl-CoA-binding domain-containing protein 5 isoform X8

UniProtKB/TrEMBL

A0A7I2V690
XM_054367131.1 → XP_054223106.1 acyl-CoA-binding domain-containing protein 5 isoform X5

UniProtKB/TrEMBL

A0A7I2V556
XM_054367133.1 → XP_054223108.1 acyl-CoA-binding domain-containing protein 5 isoform X7
XM_054367140.1 → XP_054223115.1 acyl-CoA-binding domain-containing protein 5 isoform X14
XM_054367138.1 → XP_054223113.1 acyl-CoA-binding domain-containing protein 5 isoform X12