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    ZNF24 zinc finger protein 24 [ Homo sapiens (human) ]

    Gene ID: 7572, updated on 28-Oct-2024

    Summary

    Official Symbol
    ZNF24provided by HGNC
    Official Full Name
    zinc finger protein 24provided by HGNC
    Primary source
    HGNC:HGNC:13032
    See related
    Ensembl:ENSG00000172466 MIM:194534; AllianceGenome:HGNC:13032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX17; RSG-A; ZNF191; ZSCAN3; Zfp191
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 22.0), brain (RPKM 18.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF24 in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (35332227..35344420, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (35523566..35535760, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (32912191..32924384, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 397 Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13222 Neighboring gene zinc finger protein 271, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32904859-32905554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13223 Neighboring gene uncharacterized LOC124904283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9396 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32934967-32935487 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32936140-32936672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9399 Neighboring gene zinc finger protein 396 Neighboring gene ribosomal protein L7a pseudogene 67

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 24
    Names
    retinoic acid suppression protein A
    zinc finger and SCAN domain-containing protein 3
    zinc finger protein 191
    zinc finger protein 24 (KOX 17)
    zinc finger protein KOX17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308123.2NP_001295052.1  zinc finger protein 24 isoform 2

      See identical proteins and their annotated locations for NP_001295052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' structures compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC116447, AF542097, BG436261, CA314100
      Consensus CDS
      CCDS77175.1
      UniProtKB/Swiss-Prot
      P17028
      Related
      ENSP00000467655.1, ENST00000589881.5
      Conserved Domains (1) summary
      smart00431
      Location:48160
      SCAN; leucine rich region
    2. NM_001375815.1NP_001362744.1  zinc finger protein 24 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116447
      Consensus CDS
      CCDS11912.1
      UniProtKB/Swiss-Prot
      O14754, P17028, Q53YE4, Q6ICR5, Q8IZN4
      Related
      ENSP00000382015.2, ENST00000399061.3
      Conserved Domains (3) summary
      smart00431
      Location:48160
      SCAN; leucine rich region
      COG5048
      Location:305358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253273
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_006965.4NP_008896.2  zinc finger protein 24 isoform 1

      See identical proteins and their annotated locations for NP_008896.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116447
      Consensus CDS
      CCDS11912.1
      UniProtKB/Swiss-Prot
      O14754, P17028, Q53YE4, Q6ICR5, Q8IZN4
      Related
      ENSP00000261332.5, ENST00000261332.11
      Conserved Domains (3) summary
      smart00431
      Location:48160
      SCAN; leucine rich region
      COG5048
      Location:305358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253273
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      35332227..35344420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      35523566..35535760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)