KLK11 kallikrein related peptidase 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLK11provided by HGNC
Official Full Name: kallikrein related peptidase 11provided by HGNC
Primary source: HGNC:HGNC:6359
See related: Ensembl:ENSG00000167757 MIM:604434; AllianceGenome:HGNC:6359
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IEKD; TLSP; PRSS20
Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
Expression: Biased expression in esophagus (RPKM 58.7), skin (RPKM 44.2) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (51022236..51027991, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (54110750..54116506, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (51525492..51531247, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway.
Title: miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway.
KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.
Title: KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.
KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/beta-catenin signaling.
Title: KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/β-catenin signaling.
Kallikrein 11 Down-regulation in Breast Carcinoma: Correlation With Prognostic Parameters.
Title: Kallikrein 11 Down-regulation in Breast Carcinoma: Correlation With Prognostic Parameters.
Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
Title: Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
Diagnostic and prognostic values of KLK11 in nasopharyngeal carcinoma.
Title: Diagnostic and prognostic values of KLK11 in nasopharyngeal carcinoma.
The functional role of glycosylation in prostate-specific KLK11 could pave the way to a deeper understanding of their biology and to medical applications.
Title: Activation and activity of glycosylated KLKs 3, 4 and 11.
novel KLK11 and KLK12 splice variants represent new potential cancer biomarkers
Title: Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology.
Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Title: Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer
Title: Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Ichthyosis with erythrokeratoderma MedGen: C5882691 OMIM: 620507 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH102947 (e-PCR)
- UniSTS:97281

L18426 (e-PCR)
- UniSTS:34648

SHGC-57422 (e-PCR)
- UniSTS:62672

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-11

Names: hK11; hippostasin; serine protease 20; trypsin-like protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136032.3 → NP_001129504.1 kallikrein-11 isoform 1 precursor

See identical proteins and their annotated locations for NP_001129504.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' terminal exon, which results in a downstream translation start codon, compared to variant 2. The encoded isoform (1) has a shorter N-terminus than isoform 2, and is preferentially expressed in brain. Variants 1 and 4 encode the same isoform 1.

Source sequence(s)

AB259014, BG697071

Consensus CDS

CCDS12819.1

UniProtKB/TrEMBL

A0A1R3UDR5

Related

ENSP00000413958.2, ENST00000453757.8

Conserved Domains (1) summary

smart00020
Location:21 → 243

Tryp_SPc; Trypsin-like serine protease
NM_001167605.2 → NP_001161077.1 kallikrein-11 isoform 3 precursor

See identical proteins and their annotated locations for NP_001161077.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' terminal exon, which results in a downstream translation start codon, and has an alternate splice junction in the coding region, compared to variant 2. The encoded isoform (3) has a shorter N-terminus and an additional internal segment, compared to isoform 2.

Source sequence(s)

AB078780, BC022068

Consensus CDS

CCDS54297.1

UniProtKB/Swiss-Prot

Q9UBX7

Related

ENSP00000375680.2, ENST00000391804.7

Conserved Domains (2) summary

smart00020
Location:21 → 268

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:22 → 271

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_006853.3 → NP_006844.1 kallikrein-11 isoform 1 precursor

See identical proteins and their annotated locations for NP_006844.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) has an alternate 5' terminal exon, which results in a downstream translation start codon, compared to variant 2. The encoded isoform (1) has a shorter N-terminus than isoform 2, and is preferentially expressed in brain. Variants 1 and 4 encode the same isoform 1.

Source sequence(s)

BC022068

Consensus CDS

CCDS12819.1

UniProtKB/TrEMBL

A0A1R3UDR5

Related

ENSP00000324269.6, ENST00000319720.11

Conserved Domains (1) summary

smart00020
Location:21 → 243

Tryp_SPc; Trypsin-like serine protease
NM_144947.3 → NP_659196.1 kallikrein-11 isoform 2 precursor

See identical proteins and their annotated locations for NP_659196.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2) which is preferentially expressed in prostate. This variant represents use of an mammalian interspersed repeat (MIR) alternate promoter and exon sequence. (PMID: 14550626)

Source sequence(s)

AB041036, DB457266

Consensus CDS

CCDS12818.1

UniProtKB/Swiss-Prot

O75837, Q0WXX5, Q8IXD7, Q9NS65, Q9UBX7

Related

ENSP00000473047.1, ENST00000594768.5

Conserved Domains (2) summary

smart00020
Location:53 → 275

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:54 → 278

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

51022236..51027991 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438107.1 → XP_047294063.1 kallikrein-11 isoform X2
XM_005258439.4 → XP_005258496.1 kallikrein-11 isoform X3

Conserved Domains (2) summary

smart00020
Location:47 → 134

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:45 → 137

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_011526369.2 → XP_011524671.1 kallikrein-11 isoform X1

UniProtKB/Swiss-Prot

Q9UBX7

Conserved Domains (2) summary

smart00020
Location:53 → 300

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:54 → 303

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_047438106.1 → XP_047294062.1 kallikrein-11 isoform X2
XM_047438105.1 → XP_047294061.1 kallikrein-11 isoform X2
XM_011526370.3 → XP_011524672.1 kallikrein-11 isoform X2

See identical proteins and their annotated locations for XP_011524672.1

UniProtKB/Swiss-Prot

Q9UBX7

Conserved Domains (2) summary

smart00020
Location:21 → 268

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:22 → 271

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_011526372.3 → XP_011524674.1 kallikrein-11 isoform X2

See identical proteins and their annotated locations for XP_011524674.1

UniProtKB/Swiss-Prot

Q9UBX7

Conserved Domains (2) summary

smart00020
Location:21 → 268

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:22 → 271

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_011526371.3 → XP_011524673.1 kallikrein-11 isoform X2

See identical proteins and their annotated locations for XP_011524673.1

UniProtKB/Swiss-Prot

Q9UBX7

Conserved Domains (2) summary

smart00020
Location:21 → 268

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:22 → 271

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_047438104.1 → XP_047294060.1 kallikrein-11 isoform X2
XM_011526373.2 → XP_011524675.1 kallikrein-11 isoform X2

See identical proteins and their annotated locations for XP_011524675.1

UniProtKB/Swiss-Prot

Q9UBX7

Conserved Domains (2) summary

smart00020
Location:21 → 268

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:22 → 271

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...