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    C8orf17 chromosome 8 putative open reading frame 17 [ Homo sapiens (human) ]

    Gene ID: 100507249, updated on 10-Oct-2023

    Summary

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    Official Symbol
    C8orf17provided by HGNC
    Official Full Name
    chromosome 8 putative open reading frame 17provided by HGNC
    Primary source
    HGNC:HGNC:17737
    See related
    Ensembl:ENSG00000250733 MIM:616992; AllianceGenome:HGNC:17737
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOST1; MOST-1
    Summary
    Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See C8orf17 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (139931420..139933944)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (141051303..141053826)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (140943664..140946188)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 9 Neighboring gene uncharacterized LOC107986981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:140875463-140876436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:140886258-140886840 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:140906595-140907794 Neighboring gene MPRA-validated peak7187 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:140920429-140920932 Neighboring gene uncharacterized LOC105375781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:140926649-140927188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:140949298-140949857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:140951259-140951760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:140951761-140952260 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:140965559-140965725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:140983608-140984108 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141058150-141058375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141067573-141068074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141071871-141072712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141109891-141110390 Neighboring gene paternally expressed 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas. van Duin M, et al. Cytogenet Genome Res, 2007. PMID 18000363
    2. The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate. Tan JM, et al. Mol Pathol, 2003 Apr. PMID 12665628, Free PMC Article
    3. Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers. Tan JM, et al. Int J Oncol, 2007 Jan. PMID 17143515
    4. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, overexpressed/amplified in high grade cancers of the breast and prostate; suggesting a role for MOST-1 in proliferation and carcinogenesis.
      Title: The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate.
    2. MOST-1 is associated with cell survival, proliferation and progression of breast and prostate cancer cells.
      Title: Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    Other Names

    • MOLT-4 T-cell lymphoblastic leukemia sequence tag-1
    • MOLT-4 sequence tag-1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_172942.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC021744
      Related
      ENST00000507535.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      139931420..139933944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      141051303..141053826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020237.1: Suppressed sequence

      Description
      NM_020237.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRJ1.1 GenPept UniProtKB/Swiss-Prot:Q9NRJ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials