NR4A1 nuclear receptor subfamily 4 group A member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NR4A1provided by HGNC
Official Full Name: nuclear receptor subfamily 4 group A member 1provided by HGNC
Primary source: HGNC:HGNC:7980
See related: Ensembl:ENSG00000123358 MIM:139139; AllianceGenome:HGNC:7980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77
Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Expression: Broad expression in adrenal (RPKM 103.3), ovary (RPKM 73.7) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (52022832..52059503)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (51986402..52023082)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (52416616..52453287)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Long Non-Coding RNA MALAT1 Modulates NR4A1 Expression through a Downstream Regulatory Element in Specific Cancer Cell Types.
Title: The Long Non-Coding RNA MALAT1 Modulates NR4A1 Expression through a Downstream Regulatory Element in Specific Cancer Cell Types.
Progressive reduction of nuclear receptor Nr4a1 mediates age-dependent cognitive decline.
Title: Progressive reduction of nuclear receptor Nr4a1 mediates age-dependent cognitive decline.
Yin Yang 1 suppresses apoptosis and oxidative stress injury in SH-SY5Y cells by facilitating NR4A1 expression.
Title: Yin Yang 1 suppresses apoptosis and oxidative stress injury in SH-SY5Y cells by facilitating NR4A1 expression.
NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Title: NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
SOCS3, Transcriptionally Activated by NR4A1, Induces Apoptosis and Extracellular Matrix Degradation of Vaginal Fibroblasts in Pelvic Organ Prolapse.
Title: SOCS3, Transcriptionally Activated by NR4A1, Induces Apoptosis and Extracellular Matrix Degradation of Vaginal Fibroblasts in Pelvic Organ Prolapse.
Hyperinsulinemia impairs decidualization via AKT-NR4A1 signaling: new insight into polycystic ovary syndrome (PCOS)-related infertility.
Title: Hyperinsulinemia impairs decidualization via AKT-NR4A1 signaling: new insight into polycystic ovary syndrome (PCOS)-related infertility.
Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.
Title: Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.
Chemokine receptor CXCR4 interacts with nuclear receptor Nur77 and promote glioma invasion and progression.
Title: Chemokine receptor CXCR4 interacts with nuclear receptor Nur77 and promote glioma invasion and progression.
Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFalpha, caspase 8, STAT3, and Akt pathways modulators.
Title: Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators.
Transient downregulation of NR4A1 leads to impaired osteoblast differentiation through the TGF-ss pathway, and Elesclomol (STA-4783) rescues this phenotype.
Title: Transient downregulation of NR4A1 leads to impaired osteoblast differentiation through the TGF-ß pathway, and Elesclomol (STA-4783) rescues this phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (244)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The gene expression of NR4A1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells	PubMed
Vpr	vpr	HIV-1 Vpr downregulates expression of the gene coding for growth factor-inducible nuclear protein N10 in PHA-stimulated PBMC	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S1712 (e-PCR)
- UniSTS:20013

D8S2279 (e-PCR)
- UniSTS:473907

PMC109903P1 (e-PCR)
- UniSTS:270180

RH80778 (e-PCR)
- UniSTS:87410

Nr4a1 (e-PCR), detects polymorphism
- UniSTS:536539

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to corticotropin-releasing hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fibroblast growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotransmitter secretion involved in regulation of skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in non-canonical inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type B pancreatic cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in skeletal muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear receptor subfamily 4immunitygroup A member 1

Names: ST-59; TR3 orphan receptor; early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; nuclear hormone receptor NUR/77; orphan nuclear receptor HMR; orphan nuclear receptor TR3; steroid receptor TR3; testicular receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202233.2 → NP_001189162.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform 2

See identical proteins and their annotated locations for NP_001189162.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (2) has a shorter N-terminus compared to isoform 3.

Source sequence(s)

AC025259, AK297526, BG057763

Consensus CDS

CCDS55828.1

UniProtKB/TrEMBL

Q8N3V2

Related

ENSP00000353427.3, ENST00000360284.7

Conserved Domains (2) summary

cd07348
Location:374 → 611

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:278 → 352

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
NM_001202234.2 → NP_001189163.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AC025259, AK131566, BG057763

Consensus CDS

CCDS73471.1

UniProtKB/TrEMBL

F5GXF0, Q6ZMM6

Related

ENSP00000440864.1, ENST00000545748.5

Conserved Domains (2) summary

cd07348
Location:415 → 652

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:319 → 393

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
NM_002135.5 → NP_002126.2 nuclear receptor subfamily 4immunitygroup A member 1 isoform 1

See identical proteins and their annotated locations for NP_002126.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AC025259, BC016147

Consensus CDS

CCDS8818.1

UniProtKB/Swiss-Prot

B4DML7, P22736, Q15627, Q53Y00, Q6IBU8

UniProtKB/TrEMBL

Q8N3V2

Related

ENSP00000243050.1, ENST00000243050.5

Conserved Domains (3) summary

cd07348
Location:361 → 598

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:265 → 339

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

pfam15694
Location:135 → 230

Med26_M; Mediator complex subunit 26 middle domain
NM_173157.3 → NP_775180.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform 1

See identical proteins and their annotated locations for NP_775180.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AC025259, BG057763, L13740

Consensus CDS

CCDS8818.1

UniProtKB/Swiss-Prot

B4DML7, P22736, Q15627, Q53Y00, Q6IBU8

UniProtKB/TrEMBL

Q8N3V2

Related

ENSP00000378302.1, ENST00000394825.6

Conserved Domains (3) summary

cd07348
Location:361 → 598

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:265 → 339

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

pfam15694
Location:135 → 230

Med26_M; Mediator complex subunit 26 middle domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

52022832..52059503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005268822.4 → XP_005268879.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X2

See identical proteins and their annotated locations for XP_005268879.1

UniProtKB/TrEMBL

Q6ZMM6

Conserved Domains (2) summary

cd07348
Location:433 → 670

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:337 → 411

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_047428755.1 → XP_047284711.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X1
XM_047428756.1 → XP_047284712.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X3
XM_047428757.1 → XP_047284713.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X6
XM_017019248.2 → XP_016874737.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X7
XM_017019249.2 → XP_016874738.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X8
XM_005268824.4 → XP_005268881.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X5

See identical proteins and their annotated locations for XP_005268881.1

UniProtKB/Swiss-Prot

B4DML7, P22736, Q15627, Q53Y00, Q6IBU8

UniProtKB/TrEMBL

Q8N3V2

Conserved Domains (3) summary

cd07348
Location:361 → 598

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:265 → 339

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

pfam15694
Location:135 → 230

Med26_M; Mediator complex subunit 26 middle domain
XM_017019247.2 → XP_016874736.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X4

UniProtKB/TrEMBL

Q8N3V2

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

51986402..52023082

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054371903.1 → XP_054227878.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X2
XM_054371906.1 → XP_054227881.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X7
XM_054371907.1 → XP_054227882.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X8
XM_054371905.1 → XP_054227880.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X5

UniProtKB/Swiss-Prot

B4DML7, P22736, Q15627, Q53Y00, Q6IBU8
XM_054371904.1 → XP_054227879.1 nuclear receptor subfamily 4immunitygroup A member 1 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_173158.1: Suppressed sequence

Description

NM_173158.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.