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    BROX BRO1 domain and CAAX motif containing [ Homo sapiens (human) ]

    Gene ID: 148362, updated on 28-Oct-2024

    Summary

    Official Symbol
    BROXprovided by HGNC
    Official Full Name
    BRO1 domain and CAAX motif containingprovided by HGNC
    Primary source
    HGNC:HGNC:26512
    See related
    Ensembl:ENSG00000162819 AllianceGenome:HGNC:26512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1orf58
    Summary
    Involved in mitotic nuclear membrane reassembly. Located in nuclear envelope. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in colon (RPKM 10.5), brain (RPKM 10.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BROX in Genome Data Viewer
    Location:
    1q41
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (222712564..222735187)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (221946320..221968943)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222885906..222908529)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene prefoldin subunit 5-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:222816645-222817522 and GRCh37_chr1:222817523-222818398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2581 Neighboring gene axin interactor, dorsalization associated Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5183 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:222885601-222886515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5205 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222909786-222910327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1836 Neighboring gene family with sequence similarity 177 member B Neighboring gene uncharacterized LOC105372984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2584

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32421, MGC142195, MGC142197, RP11-452F19.1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitotic nuclear membrane reassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    BRO1 domain-containing protein BROX

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288579.2NP_001275508.1  BRO1 domain-containing protein BROX isoform b

      See identical proteins and their annotated locations for NP_001275508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK056983, AL392172, AL701416, BC143811, DB504492
      Consensus CDS
      CCDS73037.1
      UniProtKB/TrEMBL
      B7Z1V1
      Related
      ENSP00000478496.1, ENST00000612948.4
      Conserved Domains (1) summary
      cd09243
      Location:4324
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    2. NM_001288580.2NP_001275509.1  BRO1 domain-containing protein BROX isoform b

      See identical proteins and their annotated locations for NP_001275509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK315930, AL392172, DC418391
      Consensus CDS
      CCDS73037.1
      UniProtKB/TrEMBL
      B7Z1V1
      Related
      ENSP00000441080.1, ENST00000539697.5
      Conserved Domains (1) summary
      cd09243
      Location:4324
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    3. NM_001288581.2NP_001275510.1  BRO1 domain-containing protein BROX isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK056983, AK304445, AL392172, DC418391
      Consensus CDS
      CCDS73036.1
      UniProtKB/TrEMBL
      B7Z953, F5GXQ0
      Related
      ENSP00000440041.1, ENST00000537020.5
      Conserved Domains (1) summary
      cd09243
      Location:4330
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    4. NM_001375661.1NP_001362590.1  BRO1 domain-containing protein BROX isoform a

      Status: VALIDATED

      Source sequence(s)
      AL392172
      Consensus CDS
      CCDS1534.1
      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
      UniProtKB/TrEMBL
      B7Z1V1
      Conserved Domains (1) summary
      cd09243
      Location:4356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    5. NM_001375758.1NP_001362687.1  BRO1 domain-containing protein BROX isoform d

      Status: VALIDATED

      Source sequence(s)
      AL392172
      UniProtKB/TrEMBL
      B7Z1V1
      Conserved Domains (1) summary
      cd09243
      Location:1300
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    6. NM_144695.4NP_653296.2  BRO1 domain-containing protein BROX isoform a

      See identical proteins and their annotated locations for NP_653296.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK056983, AL392172, AL701416, BC113635, DB504492
      Consensus CDS
      CCDS1534.1
      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
      UniProtKB/TrEMBL
      B7Z1V1
      Related
      ENSP00000343742.5, ENST00000340934.10
      Conserved Domains (1) summary
      cd09243
      Location:4356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

    RNA

    1. NR_109927.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several exons and uses an alternate 3'-terminal exon, compared to variant 1. This variant is represented as non-coding because it does not encode a supported protein.
      Source sequence(s)
      AK056983, AL392172, AL701416, BC053552, BC105293, DB504492
      Related
      ENST00000496267.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      222712564..222735187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446853.1XP_047302809.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    2. XM_047446889.1XP_047302845.1  BRO1 domain-containing protein BROX isoform X5

    3. XM_047446879.1XP_047302835.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    4. XM_017000374.3XP_016855863.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
      UniProtKB/TrEMBL
      B7Z1V1
      Conserved Domains (1) summary
      cd09243
      Location:4356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    5. XM_006711173.5XP_006711236.1  BRO1 domain-containing protein BROX isoform X1

      UniProtKB/TrEMBL
      B7Z1V1
      Conserved Domains (1) summary
      cd09243
      Location:21373
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    6. XM_011509214.4XP_011507516.1  BRO1 domain-containing protein BROX isoform X2

      See identical proteins and their annotated locations for XP_011507516.1

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
      UniProtKB/TrEMBL
      B7Z1V1
      Conserved Domains (1) summary
      cd09243
      Location:4356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    7. XM_005273069.6XP_005273126.1  BRO1 domain-containing protein BROX isoform X5

      UniProtKB/TrEMBL
      B7Z1V1
      Conserved Domains (1) summary
      cd09243
      Location:1301
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins
    8. XM_047446864.1XP_047302820.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    9. XM_047446839.1XP_047302795.1  BRO1 domain-containing protein BROX isoform X1

    10. XM_047446888.1XP_047302844.1  BRO1 domain-containing protein BROX isoform X3

    11. XM_047446886.1XP_047302842.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    12. XM_017000375.3XP_016855864.2  BRO1 domain-containing protein BROX isoform X4

    13. XM_047446890.1XP_047302846.1  BRO1 domain-containing protein BROX isoform X6

      Related
      ENSP00000398862.1, ENST00000426638.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      221946320..221968943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334562.1XP_054190537.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    2. XM_054334570.1XP_054190545.1  BRO1 domain-containing protein BROX isoform X5

    3. XM_054334565.1XP_054190540.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    4. XM_054334566.1XP_054190541.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    5. XM_054334560.1XP_054190535.1  BRO1 domain-containing protein BROX isoform X1

    6. XM_054334564.1XP_054190539.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    7. XM_054334571.1XP_054190546.1  BRO1 domain-containing protein BROX isoform X5

    8. XM_054334563.1XP_054190538.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    9. XM_054334561.1XP_054190536.1  BRO1 domain-containing protein BROX isoform X1

    10. XM_054334568.1XP_054190543.1  BRO1 domain-containing protein BROX isoform X3

    11. XM_054334567.1XP_054190542.1  BRO1 domain-containing protein BROX isoform X2

      UniProtKB/Swiss-Prot
      B7Z9G5, Q5VW32, Q96MG1
    12. XM_054334569.1XP_054190544.1  BRO1 domain-containing protein BROX isoform X4

    13. XM_054334572.1XP_054190547.1  BRO1 domain-containing protein BROX isoform X6